Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

Abstract

Spinel copper ferrite (CuFe 2 O 4 ) and zinc ferrite (ZnFe 2 O 4 ) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). XRD patterns conform to the copper ferrite and zinc ferrite formation, and the average particle sizes were calculated by using a transmission electron microscope, the measured particle sizes being 56 nm for CuFe 2 O 4 and 68 nm for ZnFe 2 O 4. Both spinel ferrite nanoparticles exhibit ferromagnetic behavior with saturation magnetization of 31 emug´1 for copper ferrite (50.63 Am 2 /Kg) and 28.8 Am 2 /Kg for zinc ferrite. Both synthesized ferrite nanoparticles were equally effective in scavenging 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radicals. ZnFe 2 O 4 and CuFe 2 O 4 nanoparticles showed 30.57%˘1.0% and 28.69%˘1.14% scavenging activity at 125 µg/mL concentrations. In vitro cytotoxicity study revealed higher concentrations (>125 µg/mL) of ZnFe 2 O 4 and CuFe 2 O 4 with increased toxicity against MCF-7 cells, but were found to be non-toxic at lower concentrations suggesting their biocompatibility.

Toxicity and biodegradation of zinc ferrite nanoparticles in Xenopus laevis

“…The potential use of zinc ferrite NPs in biomedicine requires an in-depth study of the possible toxicity induced by NPs administration. Previous studies have reported the induction of chromosomal aberration in the meristematic root sunflower cells (Foca-Nici, Capraru and Creanga, 2010), the generation of cyto-and genotoxicity in human amnion epithelial (WISH) cell line (Saquib et al, 2013), cytotoxicity and oxidative stress in different human cells (Alhadlaq, Akhtar and Ahamed, 2015), as well as antioxidant activity (Kanagesan et al, 2016). However, the lack of consensus in the experimental conditions (methods, materials, and cell lines used) makes it difficult to obtain edifying conclusions.…”

Study on the synthesis of 1,3,5-triazinane derivatives on copper-ferrite nanoparticles catalyst

“…The synthesis of nitrogen containing compounds and their derivatives provides unlimited potential for creating novel pharmacologically active lead compounds for use as therapeutics [6]. 1,3,5-triaryl triazinanes have emerged as an important target molecule for chemists due to their therapeutic and pharmacological properties such as antitubercolosis [7], antimicrobial [8], antifungal [9] anticancer [10], antioxidant and cytotoxicity [11,12], anti malarial [13], corrosion inhibitor for oil and gas industry [14]. They also serve as key intermediates for synthesis of α-and βamino esters, natural alkaloids [15], etc.…”

Magnetic Nanoparticles for Biomedical Purposes: Modern Trends and Prospects

“…Metal nanoparticles (Fe [5,6] Co [7]); • Alloys (Au/Fe [8], Fe/Co [9,10]); • Oxides (γ-Fe 2 O 3 , Fe 3 O 4 , NiO [11]); • Ferrites (CoFe 2 O 4 [12][13][14][15], NiFe 2 O 4 [16], MnFe 2 O 4 [17], ZnFe 2 O 4 [18,19]).…”

“…ZnFe 2 O 4 nanoparticles are preferred for biomedical use among all ferrites due to the low toxicity of zinc ions (they are non-toxic and biocompatible at ZnFe 2 O 4 concentrations below 125 µg/mL). These particles are considered promising T 2 MRS agents as magnetic vectors for targeted drug delivery [18,19].…”