Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050

Seephonkai, Prapairat; Isaka, Masahiko; Kittakoop, Prasat; Palittapongarnpim, Prasit; Kamchonwongpaisan, Sumalee; Tanticharoen, Morakot; Thebtaranonth, Yodhathai

doi:10.1055/s-2002-20055

Cited by 47 publications

(40 citation statements)

References 19 publications

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“…The H-6 at d 7.02 showed strong correlations ( 3 J CH ) to C-5, -8, and -9a, and weaker correlations ( 2 J CH or 4 J CH ) to C-7 and -9 in the HMBC spectrum. The H-5 at d 7.37 on the other hand displayed strong correlations ( 3 J CH ) to C-4, -6, -9a, and -10a, and weaker correlations ( 2 J CH or 4 J CH ) to C-1, -4a, -5a, -9, and -10. The 13 C NMR chemical shift data of the carbonyl and the aromatic carbons in 1 were almost identical to those in semivioxanthin (3), except that the methine C-8 signal at d 99.1 in 3 [8] was replaced by a quaternary carbon signal at 109.02 in 1.…”

Section: Resultsmentioning

confidence: 95%

Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

Bigelis

Yang

et al. 2005

J Antibiot

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Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonstrate that lichenassociated fungi potentially are a good resource for new bioactive natural products for current screening programs.

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Section: Resultsmentioning

confidence: 95%

Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

Bigelis

Yang

et al. 2005

J Antibiot

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“…They were originally detected in the lichenicolous fungus Microsphaeropsis sp. (Seephonkai et al 2002). Gonzales et al (2005) studied the biosynthetic potential of actinomycetes associated with lichens by DNA fingerprinting.…”

Section: Secondary Compounds From Microbial Associates Of Lichensmentioning

confidence: 99%

Bioactive lichen metabolites: alpine habitats as an untapped source

2010

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International audienceLichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific metabolites. Some of these are forming an available biomass for phytochemical investigations, including the assessment of biological activities of the isolated compounds. The alpine or polar region are characterised by highly stressful environmental conditions for many organisms, but lichens are among the dominating organisms in these habitats. In the performant mutual protective system, lichen fungi often accumulate high amounts of metabolites with specific physicochemical properties (UV absorbents, hydrophobicity) which help the lichens to survive. Unique secondary metabolites and polysaccharides have been isolated and tested from these organisms. Even though this has been tested until now only with a low number of compounds so far, interesting activities have been recorded. We review here some of the antimicrobial, anti-inflammatory, antiproliferative and antioxidant activities properties described. Solutions with axenic biotechnological cultivation of each symbiotic partner and particularly the mycobiont to obtain the lichen secondary metabolites are challenging to overcome the limitations for the supply of these rare compounds. Additionally, these lichens appear to harbour a diversity of culturable microorganisms from which active compounds have also been isolated recently

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“…This fungus has previously been isolated from the peduncle bark and xylem of Eucalyptus globulus (Lupo et al 2001); lichens (Seephonkai et al 2002); marine sponges including Agelus sp., collected from Sombrero Key East, Florida; Myxila incrustans, from the island of Helgoland, Germany; and Aplysina aerophoba from the Mediterranean Sea. This fungus has been reported to produce several biologically active compounds including cerebrosides (Keusgen et al 1996), unusual fatty acids and their glycerides , microsphaeropsisin, (R)-mellein, (3R, 4S)-hydroxymellein, (3R, 4R)-hydroxymellein, and 4,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (Höller et al 1999), microsphaerones A and B (Wang et al 2002), preussomerins (Seephonkai et al 2002), anthraquinones, and betaenone derivatives (Brauers et al 2000). The second fungus with biological activity was the sterile mycelia E-3, with effect against Microsporum canis, M. gypseum, Epidermophyton floccosum, Trichophyton rubrum, and T. mentagrophytes with MICs of 125, 250, 100, 100, and 125 lg/ml, respectively.…”

Section: E-19mentioning

confidence: 99%

Endophytic fungi from Chilean native gymnosperms: antimicrobial activity against human and phytopathogenic fungi

Hormazábal

Piontelli

2009

World J Microbiol Biotechnol

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Thirty-eight endophytic fungi were isolated from eight Chilean gymnosperms. Isolates were characterized and grouped according to culture characteristics, colony growth, and conidia morphology. Thirteen isolates were identified: Acremonium bacillisporum, A. bactrocephalum, A. strictum, Alternaria alternata, Aureobasidium pullulans, Chaetomium funicola, Cladosporium tenuissimum, Curvularia protuberata, C. tritici, Microsphaeropsis olivacea, Penicillium chrysogenum, P. janczewskii, and Triblidiopycnis pinastri. Malbranchea and Stegonosporium were identified at the genus level. Fourteen isolates, considered to be sterile mycelia, did not fructify in the culture medium. Crude extracts of liquid cultures from endophytes were examined for antibacterial and antifungal activity against bacteria and phytopathogenic fungi using agar diffusion. Antifungal activity against pathogenic fungi was determined by microdilution assays. Extracts of Acremonium bactrocephalum, Microsphaeropsis olivacea, and isolate E-3 inhibited growth of selected pathogenic organisms, indicating they merit further study. This is the first comparative report on the antimicrobial activity of endophytic fungi from Chilean gymnosperms.

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Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050

Cited by 47 publications

References 19 publications

Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

Bioactive lichen metabolites: alpine habitats as an untapped source

Endophytic fungi from Chilean native gymnosperms: antimicrobial activity against human and phytopathogenic fungi

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