Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

He, Haiyin; Bigelis, Ramunas; Yang, Hui; Chang, Liping; Singh, Manpreet

doi:10.1038/ja.2005.99

Cited by 17 publications

(17 citation statements)

References 14 publications

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“…Although ecological, taxonomical, and phylogenetic studies of North American lichens have been active study areas in lichenology (Geiser et al, 2010; (He et al, 2005;Lawrey, 1989;Shrestha & St. Clair, 2013b). This study provides data based on the first broad-scale screening of lichens collected from different parts of the United States against four different pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

Shrestha

Raphael

Leavitt

et al. 2014

Pharmaceutical Biology

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Context: The emergence of antibiotic resistant pathogens is a serious global health threat. Hence, the search for new antibiotic drugs from various natural sources should be given high priority. Lichens produce a variety of low molecular weight metabolic compounds and many cultures have utilized these compounds in traditional medicine for centuries. Objective: Report the antibiotic properties of extracts from 34 North American lichens screened against four pathogenic bacteria. Materials and methods: The micro-well dilution method was used to determine the minimum inhibitory concentration (MIC) of acetone and methanol extracts of 34 lichen species against four bacterial strains. Major chemical compounds in each species were identified using thin layer chromatography (TLC). Results: Most of the lichen extracts demonstrated inhibitory effects against Staphylococcus aureus, Pseudomonas aeruginosa, and methicillin-resistant S. aureus (MRSA) with MIC values ranging from 3.9 to 500 mg/ml. In addition, extracts from three species, Letharia columbiana (Nutt.) J. W. Thomson (Parmeliaceae), Letharia vulpina (L.) Hue (Parmeliaceae), and Vulpicida canadensis (Räsänen) J.-E. Mattsson & M. J. Lai (Parmeliaceae) (MIC ¼ 125-500 mg/ml) were also effective against Escherichia coli. Generally, acetone extractions were found to be more effective than methanol extractions. Discussion and conclusion: Results of this study show that lichen extracts provide significant antimicrobial activity against both Gram-positive and Gram-negative bacteria. These results suggest that lichens may be an important potential source of antibacterial drugs.

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Section: Discussionmentioning

confidence: 99%

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

Shrestha

Raphael

Leavitt

et al. 2014

Pharmaceutical Biology

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“…For example, cyclodipeptide cordysinin A, first identified in the caterpillar fungus C. sinensis [ 32 ], was detected in our metabolomic data. Additional compounds first identified in non-insect pathogens were also detected, including the antibiotic fumimycin first reported in Aspergillus fumisynnematus [ 33 ], lichenicolin A reported in a lichenicolous fungus [ 34 ], alkaloid sinensine B from the basidiomycete Ganoderma sinense [ 35 ], and cycloheximide acid A from a bacterium [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Omics data reveal the unusual asexual-fruiting nature and secondary metabolic potentials of the medicinal fungus Cordyceps cicadae

Luo

Cen

et al. 2017

BMC Genomics

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BackgroundAscomycete Cordyceps species have been using as valued traditional Chinese medicines. Particularly, the fruiting bodies of Cordyceps cicadae (syn. Isaria cicadae) have long been utilized for the treatment of chronic kidney disease. However, the genetics and bioactive chemicals in this fungus have been largely unexplored.ResultsIn this study, we performed comprehensive omics analyses of C. cicadae, and found that, in contrast to other Cordyceps fungi, C. cicadae produces asexual fruiting bodies with the production of conidial spores instead of the meiotic ascospores. Genome sequencing and comparative genomic analysis indicate that the protein families encoded by C. cicadae are typical of entomopathogenic fungi, including the expansion of proteases and chitinases for targeting insect hosts. Interestingly, we found that the MAT1-2 mating-type locus of the sequenced strain contains an abnormally truncated MAT1-1-1 gene. Gene deletions revealed that asexual fruiting of C. cicadae is independent of the MAT locus control. RNA-seq transcriptome data also indicate that, compared to growth in a liquid culture, the putative genes involved in mating and meiosis processes were not up-regulated during fungal fruiting, further supporting asexual reproduction in this fungus. The genome of C. cicadae encodes an array of conservative and divergent gene clusters for secondary metabolisms. Based on our analysis, the production of known carcinogenic metabolites by this fungus could be potentially precluded. However, the confirmed production of oosporein raises health concerns about the frequent consumption of fungal fruiting bodies.ConclusionsThe results of this study expand our knowledge of fungal genetics that asexual fruiting can occur independent of the MAT locus control. The obtained genomic and metabolomic data will benefit future investigations of this fungus for medicinal uses.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-017-4060-4) contains supplementary material, which is available to authorized users.

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“…In another study, fungi interacting with lichens were reported to produce natural products such as bis-naphtopyrones and lichenicolins A and B, both of which have activity against Gram-positive bacteria [73]. Co-culturing an unidentified bacterium with the fungus Libertella sp., diterpenoids-including libertellenone A-D--were discovered.…”

Section: Bacterial-fungal Interactions and Natural Product Discoverymentioning

confidence: 98%

Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi

Haq

Elsas

2015

Fungal Biology

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Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

Cited by 17 publications

References 14 publications

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

Omics data reveal the unusual asexual-fruiting nature and secondary metabolic potentials of the medicinal fungus Cordyceps cicadae

Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi

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