Evaluation of antimicrobial susceptibility of Escherichia coli strains isolated in Rabat University Hospital (Morocco)

Alem, Nathalia Helena; Frikh, Mohammed; Srifi, A.; Maleb, Adil; Chadli, Mariama; Sekhsokh, Yassine; Louzi, Lhoucin; Ibrahimi, Azeddine; Lemnouer, Abdelhay; Elouennass, Mostafa

doi:10.1186/s13104-015-1380-9

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…In this work, the predominant microorganisms were represented by Gram-negative bacteria, with a frequency of 77.41%. Our observations corroborate with previous studies carried out in several countries ( 6 , 11 , 12 ). E. coli and K. pneumoniae were the most isolated bacterial species.…”

Section: Discussionsupporting

confidence: 93%

Bacteriological profile of urinary tract infections and antibiotic susceptibility of Escherichia coli in Algeria

Ait-Mimoune¹,

Hassaine²,

Boulanoir³

2022

IJM

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Background and Objectives: Urinary tract infections are one of the most common bacterial infections worldwide. The emergence of antibiotic-resistant bacterial strains is a serious problem and greatest challenge in public health care. The pur- pose of this study was to determine the prevalence of uropathogenic microorganisms and the antibiotic resistance pattern of Escherichia coli in Algeria. Materials and Methods: Urine samples were collected from 760 outpatients in the hospital of Tizi-Ouzou (Algeria). From the positive cultures, 120 strains of E. coli were isolated and tested for their susceptibility to antibiotics by disk diffusion method on Mueller Hinton agar medium. Results: Among the collected urine specimens, 270 (35.5%) yielded positive cultures for urinary tract infection. Females were more affected with a sex ratio F/M of 1.14. E. coli was the most prevalent isolated bacteria with a rate of 44.44%, fol- lowed by Klebsiella pneumoniae (12.21%), Pseudomonas aeruginosa (11.1%) and Proteus mirabilis (5.55%). Isolates of E. coli showed high level of resistance to cephalothin (85.83%), ticarcillin (82.5%), ampicillin (73.3%) and amoxicillin-clavu- lanic acid (58.33%). Imipenem was the most effective antimicrobial agent. Conclusion: These results highlight the inappropriate utilization of antibiotics and suggest the need to improve prescription practices in our country.

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Section: Discussionsupporting

confidence: 93%

Bacteriological profile of urinary tract infections and antibiotic susceptibility of Escherichia coli in Algeria

Ait-Mimoune¹,

Hassaine²,

Boulanoir³

2022

IJM

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“…Among the aminoglycosides group, gentamycin sensitivity rate was 29%. Some researchers have reported gentamycin sensitivity rate to E.coli from 1.5% to 54% (Koksaldi-Motor et al, 2010, Kutlu, 2007, Pieboji et al, 2004, Kalem et al, 2008. Our results were compliance with previous researchers.…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial Resistance and Sensitivity among Isolates of Esherichia coli from Urine Samples in Denizli, Turkey

Kirac

Keskin

Karahasanoğlu

2018

Malays. j. med. biol. res.

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Objective: The research was carried out with isolate and determines the antimicrobial sensitivity in E. coli from urinary tract infections in special hospital in Denizli and recorded at specimens. Methods: Urine samples (n=21) were collected from patients with signs and symptoms of Urinary tract infections. Bacteria were isolated and identified by conventional biochemical profile. Antibiotic resistance pattern of E. coli against different antibiotic was determined by Kirby-Baur method. Results: The results revealed that sensitivity rate of antimicrobial agents were in the range of meropenem (100%), norfloxacin and ciprofloxacin (86%), cefotaxime (80%), aztreonam (76%). None of the samples showed no resistance to amikacin, ceftazidime, aztreonam, amoxicillin/clavulanic acid, and meropenem. Out of 21 isolates, 3(14%) isolates showed Multiple Antibiotic Resistance ten to thirteen antibiotics. Conclusion: It is concluded that most of the urinary tract infections in human are caused by E.coli exhibited highest resistance to meropenem (100%), followed by norfloxacin and ciprofloxacin (86%).We aimed in these research to determine the status of antibiotic resistance, underlying conditions, and isolation of E.coli isolates with from a special hospital in Denizli, Turkey.

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“…In the present study, the distribution of Enterobacterales resistant to 3GC and/or carbapenems according to the nature of the sample revealed that majority of the isolates were the causative agents for urinary tract infections. Tis corroborates the fndings of other studies that reported multidrug-resistant Enterobacterales as being predominantly isolated from urine samples [24,30,31,34,35]. However, others have shown that the respiratory tract (54.2%) and blood (56.49%) are the main sources of MDR isolates [26,27,29].…”

Section: Discussionsupporting

confidence: 89%

Predominance of OXA-48 Carbapenemase-Producing Enterobacterales in a Moroccan Hospital

Belouad

Maleb

Mrimar

et al. 2023

International Journal of Microbiology

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Objective. The emergence of carbapenemase-producing Enterobacterales (CPE) is a major concern that is increasingly reported worldwide. Our study aimed at investigating the resistance of CPE isolates in a Moroccan teaching hospital using phenotypic and genotypic methods. Methods. Enterobacterales strains from March to June 2018 were collected from different clinical samples. The Enterobacterales isolates resistant to third-generation cephalosporins (3GC) and/or carbapenems were subjected to the Carba NP test and an immunochromatographic test for phenotypic detection. Detection of extended-spectrum β-lactamases (ESBL) was also performed following standards. Molecular screening of carbapenemases genes (OXA-48, NDM, blaKPC, blaIMP, blaVIM, and blaOXA-24, blaOXA-23, OXA-51, OXA-58) using conventional multiplex PCR assays was also performed on 143 isolates. Results. Enterobacterales represented 52.7% with a proportion of 21.8% of bacteria resistant to 3GC and/or carbapenems. Within 143 isolates MDR to 3GC, K. pneumoniae, E. coli, and E. cloacae represent 53.1%, 40.6%, and 6.3%, respectively. These strains were isolated mainly from urinary samples (74.8%) in patients admitted to emergency and surgical units. 81.1% of strains are producing ESBL and 29% are carbapenemase producers as confirmed by the Carba NP test, immunochromatographic test, and molecular testing. OXA-48 carriers represent 83.3% of these strains, followed by NDM with 16.7%. blaKPC, blaIMP, blaVIM, and blaOXA-24, blaOXA-23, OXA-51, OXA-58 were not detected in any of these bacteria. Conclusions. A high rate of CPE carrying OXA-48 among Enterobacterales resistant to 3GC and/or carbapenems isolates was found. Strict observance of hospital hygiene measures and more rational use of antibiotics are mandatory. Implantation of carbapenemases detection should be encouraged in our hospital settings to estimate the true burden of the CPE.

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Evaluation of antimicrobial susceptibility of Escherichia coli strains isolated in Rabat University Hospital (Morocco)

Cited by 11 publications

References 22 publications

Bacteriological profile of urinary tract infections and antibiotic susceptibility of Escherichia coli in Algeria

Bacteriological profile of urinary tract infections and antibiotic susceptibility of Escherichia coli in Algeria

Antimicrobial Resistance and Sensitivity among Isolates of Esherichia coli from Urine Samples in Denizli, Turkey

Predominance of OXA-48 Carbapenemase-Producing Enterobacterales in a Moroccan Hospital

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