Evaluation of Antihyperlipidemic Activity of the Plant Cyperus Rotundus in Poloxamer Induced Hyperlipidemic Rats

Garg, Har Govind

doi:10.20959/wjpr201710-9416

Cited by 1 publication

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“…The extract was found to reduce isoproterenol induced cytosolic enzymes and restore the level of antioxidant enzymes in heart tissues. (Garg 2017), who the efficacy of C. rotundus Linn. in lowering of T. Cholesterol, triglyceride, LDL-C, and VLDL-C. (Okwu et al, 2015) found that bioactive chemicals found in the rhizome of C. rotundus exhibit hypolipidemic properties and compare favorably to the typical clinically used therapeutic hypolipidemic drug, simvastatin.…”

Section: Effect Of C Rotundus Rhizomes Ethanolic Extract On General Properties Of Diabetes and Carbohydrate Metabolism Enzymes In Alloxanmentioning

confidence: 99%

Anti-diabetic, Antioxidants, Anti-hepatorenaltoxicity Activities of <em>Cyperus rotundus </em>Rhizome Extract in Alloxan-induced Diabetic Rats

Al-Awar¹,

Alqabbani²

2021

Preprint

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Objective: The hypoglycemic, hepatorenalprotective, and antioxidant Activities of Cyperus rotundus rhizomes extract in an alloxan-induced diabetic rat model were investigated in this work.Methods: 25 Male rats were divided into 5 groups: normal control, diabetic control, diabetic of C. rotundus (200 mg/kg b.w), diabetic of C. rotundus (400 mg/kg b.w), diabetic of glibenclamide (0.6mg/kg).Treatments were administered orally for 6 weeks.Results: A single injection of alloxan to rats (150mg/kg b.w) caused pathological alterations in all studied parameters and histological structure of the pancreas. On the other hand, results showed that oral administration of C. rotundus rhizomes extract in dose of 200 and 400 mg/kg caused significant reduction in glucose, HbA1C%, α-amylase level and plasma lactate together with significant elevation in serum insulin, serum pyruvate with an improvement in insulin resistance. In line with amelioration of the diabetic state, C. rotundus rhizomes extract improved of the liver and kidney functions, and oxidative marker levels. Moreover, the extract succeeded to reduce the elevated serum total cholesterol, triglyceride (TG) and low-density lipoprotein- cholesterol (LDL-C) levels and to elevate the reduced high-density lipoprotein- cholesterol (HDL-C) level of diabetic rats.Conclusion: The investigation data concluded that C. rotundus rhizomes extract could be used as alternative treatments as antidiabetic, antioxidant and antihyperlipidemic, and agent as well as in liver and kidney protective in alloxan induced-diabetic rats. This may be related to the presence of saponin glycosides, polyphenols, flavonoids, and terpenoids in the ethanolic extract of C. rotundus rhizomes, which was discovered by phytochemical screening in this study to be present in the plant.

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Section: Effect Of C Rotundus Rhizomes Ethanolic Extract On General Properties Of Diabetes and Carbohydrate Metabolism Enzymes In Alloxanmentioning

confidence: 99%

Anti-diabetic, Antioxidants, Anti-hepatorenaltoxicity Activities of <em>Cyperus rotundus </em>Rhizome Extract in Alloxan-induced Diabetic Rats

Al-Awar¹,

Alqabbani²

2021

Preprint

View full text Add to dashboard Cite

show abstract

Evaluation of Antihyperlipidemic Activity of the Plant Cyperus Rotundus in Poloxamer Induced Hyperlipidemic Rats

Abstract: Atherosclerosis is the major cause of morbidity and mortality in the

Cited by 1 publication

References 0 publications

Anti-diabetic, Antioxidants, Anti-hepatorenaltoxicity Activities of <em>Cyperus rotundus </em>Rhizome Extract in Alloxan-induced Diabetic Rats

Anti-diabetic, Antioxidants, Anti-hepatorenaltoxicity Activities of <em>Cyperus rotundus </em>Rhizome Extract in Alloxan-induced Diabetic Rats

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