The present study was carried out to evaluate the effect of ethanol extract of seed of Mucuna pruriens (0.5 g/kg, p.o. and 1 g/kg, p.o.) on gastric ulcers. The study was carried out on different gastric ulcer models such as pylorus ligation, indomethacin induced ulcers and stress induced ulcers. Ranitidine (50 mg/kg p.o.) and misoprostol (100 µg/kg, p.o.) were used as standard drugs. Both doses of ethanol extract of seed of Mucuna pruriens showed gastric ulcer healing effect and gastric antisecretory effect in pylorus-ligated rats and also showed gastric cytoprotective effect in indomethacin-induced ulcer and also produced a significant reduction in the development of stress induced gastric ulcers. The high dose of ethanol extract of seed of Mucuna pruriens (1 g/kg, p.o.) was more effective compared to the low dose (0.5 g/kg, p.o.). Ethanol extract of seed of Mucuna pruriens showed gastric antisecretory and cytoprotective effect and prevents the development of experimentally induced gastric ulcers in rats.
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