Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism

Jiang, Yu; Fan, Liuping

doi:10.1016/j.jep.2020.112851

Cited by 34 publications

(21 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poria ethanol extract could induce apoptosis by decreasing the expression of Bcl-2 and increasing the expression of Bax, increasing the content of cytoplasm, the active forms of cleaved caspase-9 and caspase-3, and cleaved PARP, which proved that pachymic acid had an inhibitory effect on MDA-MB-231 cells. Poria ethanol extract treatment alleviated the damage to the liver and normalized the serum levels of ALT and AST in mice compared with the mice with cisplatin treatment [73]. e study showed that PA could induce apoptosis of SGC-7901 cells by inactivating the JAK2/STAT3 signaling pathway, which proved that PA was a potential bioactive substance for the treatment of gastric cancer [74].…”

Section: E Antitumor Effect Of Poriamentioning

confidence: 88%

Phytochemistry and Biological Activities of Poria

Lü

Tian

Zhou

et al. 2021

Journal of Chemistry

View full text Add to dashboard Cite

Poria is a common Traditional Chinese Medicine in clinic. In recent years, the chemical and pharmacological studies of Poria have made great progress, triterpenes and polysaccharides have been isolated, and various types of compounds containing lipids, octanoic acids, fatty acids, and trace elements have been found. In this paper, we reviewed the literature, summarized the main compound types, and reviewed in detail their pharmacological effects in antitumor, immunomodulatory, effects on kidney, hepatoprotective activity, effects on blood sugar, antioxidant effects, anti-inflammatory effects, effects on the gut, antidepressant, and so on, and also categorized the compounds with the same or similar pharmacological effects to provide a reference for the in-depth study of the material basis of the pharmacological effect, quality standards, and pharmacological activity of Poria.

show abstract

Section: E Antitumor Effect Of Poriamentioning

confidence: 88%

Phytochemistry and Biological Activities of Poria

Lü

Tian

Zhou

et al. 2021

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…For example, Ganoderma lucidum triterpenoids have a broad spectrum of inhibitory effects against a variety of cancers, including oral mucosal cancer [26], prostate cancer cells [27], and liver cancer [28]. Concordantly, triterpenes isolated from Poria cocos, a widely used medicinal fungus in TCM owing to its diverse pharmaceutical activities, has been demonstrated to suppress the progression of pancreatic cancer [29], breast cancer [30], and lung cancer [31], thus suggesting it could be considered as a novel therapeutic agent in cancer treatment (Table 1).…”

Section: Anticancer Activities Of Edible and Medicinal Fungimentioning

confidence: 99%

Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms

Shen

Jiao

et al. 2022

Nutrients

View full text Add to dashboard Cite

Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma lucidum, Cordyceps sinensis, Pleurotus ostreatus, and Grifola frondosa, have been demonstrated to possess a board range of pharmaceutical properties, including anti-virus, anti-inflammation, and neuroprotection. Moreover, edible and medicinal fungi have been traditionally consumed as food to provide multiple nutrients and as drugs owing to having the activities of invigorating blood circulation, reinforcing the healthy qi, clearing away heat, and eliminating stasis for thousands of years in China. Malignant tumors, well-known as the second leading cause of death globally, accounted for nearly 10 million deaths in 2020. Thus, in-depth exploration of strategies to prevent and treat cancer is extremely urgent. A variety of studies have reported that the main bioactive components of edible and medicinal fungi, mainly polysaccharides and triterpenoids, exhibit diverse anticancer activities via multiple mechanisms, including inhibition of cell proliferation and metastasis, induction of apoptosis and autophagy, reversing multidrug resistance, and regulation of immune responses, thus suggesting their substantial potential in the prevention and treatment of cancer. Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field. Additionally, few studies have reported the safety and efficacy of extracts from edible and medicinal fungi, which may limit their clinical application. In summary, there is a need to continue to explore the use of those extracts and to further validate their safety and efficacy.

show abstract

“…It is mainly used to treat edema and oliguria, sputum drinking and dizziness, spleen deficiency, restlessness, convulsions, and insomnia. Clinically, PCW is mainly used for treating renal fibrosis, 65 osteoporosis, 66 malignant tumors, 67 cerebral ischemia/reperfusion injury, 68 depression, 69 fatty liver, 70 diabetes, 71 and AD. 72 PC is abundantly available, and its pharmacological effects are remarkable.…”

Section: Curcumae Radix (Cr)mentioning

confidence: 99%