Phytochemistry and Biological Activities of Poria

Lü, Junfu; Tian, Jing; Zhou, Li; Meng, Lijun; Chen, Sitan; Ma, Changyang; Wang, Jinmei; Liu, Zhenhua; Li, Changqin

doi:10.1155/2021/6659775

Cited by 17 publications

(15 citation statements)

References 49 publications

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“…Ganoderma lucidum and Poria cocos are two well-known medicinal basidiomycetes. Based on the phytochemical reports, more than 270 secondary metabolites have been reported to be isolated from Ganoderma lucidum [ 60 , 61 , 62 ]; more than 140 terpenoids and more than 20 steroids have been identified in Poria cocos [ 63 , 64 ]. As reviewed by Habtemariam [ 1 ] and described in the Section 1 , the small-molecule compounds identified from D. indusiata mainly include a few terpenoids and alkaloids.…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities

et al. 2023

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As an edible and medicinal fungus, Dictyophora indusiata is well-known for its morphological elegance, distinctive taste, high nutritional value, and therapeutic properties. In this study, eighteen compounds (1–18) were isolated and identified from the ethanolic extract of D. indusiata; four (1–4) were previously undescribed. Their molecular structures and absolute configurations were determined via a comprehensive analysis of spectroscopic data (1D/2D NMR, HRESIMS, ECD, and XRD). Seven isolated compounds were examined for their anti-inflammatory activities using an in vitro model of lipopolysaccharide (LPS)-simulated BV-2 microglial cells. Compound 3 displayed the strongest inhibitory effect on tumor necrosis factor-α (TNF-α) expression, with an IC50 value of 11.9 μM. Compound 16 exhibited the highest inhibitory activity on interleukin-6 (IL-6) production, with an IC50 value of 13.53 μM. Compound 17 showed the most potent anti-inflammatory capacity by inhibiting the LPS-induced generation of nitric oxide (NO) (IC50: 10.86 μM) and interleukin-1β (IL-1β) (IC50: 23.9 μM) and by significantly suppressing induced nitric oxide synthase (iNOS) and phosphorylated nuclear factor-kappa B inhibitor-α (p-IκB-α) expression at concentrations of 5 μM and 20 μM, respectively (p < 0.01). The modes of interactions between the isolated compounds and the target inflammation-related proteins were investigated in a preliminary molecular docking study. These results provided insight into the chemodiversity and potential anti-inflammatory activities of metabolites with small molecular weights in the mushroom D. indusiata.

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Section: Discussionmentioning

confidence: 99%

Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities

et al. 2023

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“…A limited amount of research on the pharmacological activity, underlying molecular mechanisms and other new biological effects of PA warrants further investigation ( 8 ). Investigators use different methods including experimental animals ( in vivo ), tissue and cell cultures ( in vitro ) in order to investigate novel therapies of human diseases ( 94 ).…”

Section: Discussionmentioning

confidence: 99%

“…Its sclerotium, known as fu-ling or hoelen, has been widely used as a health food and in traditional Chinese medicine with pharmacological properties, including sedative, diuretic, and tonic effects (5)(6)(7). Overall, >160 terpenoids have been identified in Poria cocos (8). As an important bioactive terpenoid, PA has been reported to exhibit numerous pharmacological effects, such as cytotoxic (9), anti-inflammatory (10), antihyperglycemic (11), antibacterial and antiviral (12), sedative-hypnotic (13) and anti-ischemia/reperfusion (14) effects.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological profiles and therapeutic applications of pachymic acid (Review)

et al. 2022

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“…Wolf. Lu et al(2021 ) have been reported to involve the modulation of redox signaling including the inhibition of pro-inflammatory nuclear factor kappa B signaling and its target genes as well as the activation of antioxidative nuclear factor-erythroid-2-related factor 2 signaling and its downstream target gene in TGF-β1. Alisol B (acetate), Alisol C (monoacetate) account for 65% of chemical compounds identified from Alisma Orientale (Sam.)…”

Section: Discussionmentioning

confidence: 99%

Prediction of the Molecular Mechanisms Underlying Erlong Zuoci Treatment of Age-Related Hearing Loss via Network Pharmacology-Based Analyses Combined with Experimental Validation

Qing

Yang

et al. 2021

Front. Pharmacol.

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Background: The traditional Chinese medicine formula ErLong ZuoCi (ELZC) has been extensively used to treat age-related hearing loss (ARHL) in clinical practice in China for centuries. However, the underlying molecular mechanisms are still poorly understood.Objective: Combine network pharmacology with experimental validation to explore the potential molecular mechanisms underlying ELZC with a systematic viewpoint.Methods: The chemical components of ELZC were collected from the Traditional Chinese Medicine System Pharmacology database, and their possible target proteins were predicted using the SwissTargetPrediction database. The putative ARHL-related target proteins were identified from the database: GeneCards and OMIM. We constructed the drug-target network as well as drug-disease specific protein-protein interaction networks and performed clustering and topological property analyses. Functional annotation and signaling pathways were performed by gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. Finally, in vitro experiments were also performed to validate ELZC’s key target proteins and treatment effects on ARHL.Results: In total, 63 chemical compounds from ELZC and 365 putative ARHL-related targets were identified, and 1860 ARHL-related targets were collected from the OMIM and GeneCards. A total of 145 shared targets of ELZC and ARHL were acquired by Venn diagram analysis. Functional enrichment analysis suggested that ELZC might exert its pharmacological effects in multiple biological processes, such as cell proliferation, apoptosis, inflammatory response, and synaptic connections, and the potential targets might be associated with AKT, ERK, and STAT3, as well as other proteins. In vitro experiments revealed that ELZC pretreatment could decrease senescence-associated β-galactosidase activity in hydrogen peroxide-induced auditory hair cells, eliminate DNA damage, and reduce cellular senescence protein p21 and p53. Finally, Western blot analysis confirmed that ELZC could upregulate the predicted target ERK phosphorylation.Conclusion: We provide an integrative network pharmacology approach, in combination with in vitro experiments to explore the underlying molecular mechanisms governing ELZC treatment of ARHL. The protective effects of ELZC against ARHL were predicted to be associated with cellular senescence, inflammatory response, and synaptic connections which might be linked to various pathways such as JNK/STAT3 and ERK cascade signaling pathways. As a prosperous possibility, our experimental data suggest phosphorylation ERK is essential for ELZC to prevent degeneration of cochlear.

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Phytochemistry and Biological Activities of Poria

Cited by 17 publications

References 49 publications

Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities

Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities

Pharmacological profiles and therapeutic applications of pachymic acid (Review)

Prediction of the Molecular Mechanisms Underlying Erlong Zuoci Treatment of Age-Related Hearing Loss via Network Pharmacology-Based Analyses Combined with Experimental Validation

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