Pharmacological profiles and therapeutic applications of pachymic acid (Review)

Wei, Chunyong; Wang, Hezhen; Sun, Xun; Bai, Zhixun; Wang, Jing; Bai, Guohui; Yao, Qizheng; Xu, Yingshu; Zhang, Lei

doi:10.3892/etm.2022.11484

Cited by 16 publications

(3 citation statements)

References 89 publications

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“…Pachymic acid is a bioactive ingredient of Poria cocos with various pharmacological properties, including anti-tumor, anti-inflammatory, antioxidant, hypoglycemic, and sedative hypnosis. 169 Furthermore, pachymic acid possesses beneficial effects against fibrosis. Li et al reported that pachymic acid alleviated rat pancreatic injury and fibrosis with pancreatitis, and the inhibition of NLRP3 inflammasome is involved.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Deng,

Liu,

Chen

et al. 2024

DDDT

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With ever-increasing intensive studies of idiopathic pulmonary fibrosis (IPF), significant progresses have been made. Endoplasmic reticulum stress (ERS)/unfolded protein reaction (UPR) is associated with the development and progression of IPF, and targeting ERS/UPR may be beneficial in the treatment of IPF. Natural product is a tremendous source of new drug discovery, and accumulating studies have reported that many natural products show potential therapeutic effects for IPF via modulating one or more branches of the ERS signaling pathway. Therefore, this review focuses on critical roles of ERS in IPF development, and summarizes herbal preparations and bioactive compounds which protect against IPF through regulating ERS.

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Section: Bioactive Compoundsmentioning

confidence: 99%

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Deng,

Liu,

Chen

et al. 2024

DDDT

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“…It is well-known that Poria cocos is composed of a number of essential components, including Pachymic acid (C 33 H 52 O 5 ), Pinylic acid (C 30 H 18 O 3 ), Songnyeongsinic acid (3--Hyderoxy-lanosta-7.9 (11), 24-Trien-21-oic acid, and Tumulosic acid (C 31 H 5 ). [5] Additionally, poricoic acid and phosphoric acid (Cortoic acid (C 51 ) are also derived from this source. The substance in question comprises perishaminoic acid, abricoic acid, polypothenic acid A and C, triterpenoid, ergosterol, lecithin, adenine, choline, glucose, fructose, protein, and a significant quantity of inorganic compounds.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods

Kim,

Choi,

Park

et al. 2023

Nutrients

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Background: Since the outbreak of the pandemic started, an increase in the number of sleep disorders, including insomnia and poor sleep quality, has been seen. The pattern will probably continue. Methods: This study focuses on the preparation and clinical testing of Poria cocos extract in treating suboptimal sleep quality. The optimal extraction method utilized a 75% ethanol concentration, and the clinical investigation involved subjects with defined poor sleep taking 800 mg of the extract nightly, assessed using the Sleep Questionnaire and polysomnography. The non-parametric Wilcoxon signed-rank test was used for statistical analysis due to the non-normal distribution of the collected data. Results: The study involved 21 insomnia sufferers with a mean age of 55 who were administered Poria cocos extracts. The findings of the study indicate a statistically significant rise in the overall duration of sleep (from 327.395 ± 43.2 min to 356.516 ± 63.21 min, p = 0.014). Additionally, there was a notable decrease in the level of arousal during sleep (from 76.316 ± 44.78 min to 47.989 ± 42.38 min, p = 0.009), and an improvement in the sleep severity index of the sleep questionnaire test. Conclusions: Poria cocos as a natural substance could improve quality of sleep, based on the findings. The study investigates Pachymic acid, a substance found in Poria cocos, as a potential indicator for the development of sleeping aids.

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“…In addition, PA also showed significant anticancer activities in animal models [ 19 – 21 ] by inhibiting the growth of NCI‑H23, SGC‑7901, and MIA PaCa‑2 xenograft tumors. In a review of the pharmacological profiles and therapeutic applications of PA, we systematically summarized the anticancer potential of PA and its underlying molecular mechanisms in vitro and in vivo [ 22 ]. However, to date, there is limited knowledge regarding the modification on the structure of PA to improve its anticancer activity [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents

et al. 2022

Self Cite

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Pachymic acid, a well-known natural lanostane-type triterpenoid, exhibits various pharmacological properties. In this study, 18 derivatives of pachymic acid were synthesized by modifying their molecular structures and evaluated for their anticancer activity against two human cancer cell lines using the CCK-8 assay. Structure-activity relationship studies according to the in vitro cytotoxicity unexpectedly found one promising derivative A17 (namely tumulosic acid, also found in Poria cocos ), which had stronger anti-proliferative activity than the positive drug cisplatin against HepG2 and HSC-2 cell lines with IC 50 values of 7.36 ± 0.98 and 2.50 ± 0.15 μM, respectively. Further pharmacological analysis demonstrated that A17 induced HSC-2 cell cycle arrest at the S phase, cell apoptosis, and autophagy. Western blotting confirmed the regulatory effects of A17 on cell cycle arrest-, apoptosis-, and autophagy-related proteins expression. In addition, A17 regulated the AKT and AMPK pathways in HSC-2 cells. These results demonstrated that A17 possesses great potential as an anticancer agent. Graphical Abstract

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Pharmacological profiles and therapeutic applications of pachymic acid (Review)

Abstract: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.

Cited by 16 publications

References 89 publications

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods

Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents

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