Evaluation of anti-snake venom activity of the aqueous root extract of &lt;i&gt;Securidaca longipedunculata&lt;/i&gt; in rats

Wannang, Noel N.; Wudil, A. M.; Dapar, Maxwell L.P; Bichi, Lawal Alhassan

doi:10.4314/jpb.v2i2.32067

Cited by 11 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extracts of S. longepedunculata significantly increased levels of serum AST and ALT [7]. This is diagonistic of hepatocellular damage, as seen in the disorders that cause the death of many numerous liver cells (extensive hepatic necrosis) such as acute viral hepatitis A or B, pronounced liver damage inflicted by toxins as from an over dose of acetaminophen (paracetamol), and prolonged collapse of the circulatory system (shock) when the liver is deprived of fresh blood bringing oxygen and nutrients [12].…”

Section: Discussionmentioning

confidence: 92%

“…Urea and uric acid are also vital diagonistic tools for toxicity. It was found that aqueous extracts of the root bark of S. longepedunculata altered serum levels of these enzymes in rats [7]; an indication of the potential toxicity of the plant which could result in organ or tissue damage. The vital organs that are commonly affected are heart, liver, kidney and pancreas among others.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Toxicological Studies of Securidaca longepedunculata on the Heart, Liver, Kidney and Lungs of Rats

Haruna¹

2016

ACT

View full text Add to dashboard Cite

Securidaca lonpedunculata is a savannah plant widely distributed in Africa. The plant has a reputation of broad spectrum of medicinal, pharmacological and therapeutic properties, it is reported that almost all parts of the plant are used by man for different ailments. Our investigation examined the histopathologic effects of the methanol root extract of S. longepedunculata on the kidney, liver, lungs and the heart. Wister albino rats weighing 170 to 200 g were given 0.56, 0.28, and 0.14 mg/kg (i.p.) respectively of the extract daily for 60 days and then sacrificed. The methanol extract gave an LD50 value of 2.8 mg/kg (i.p.) and histological examinations revealed that in the kidneys, there was intense vascular congestion with kupfer cells hyperplasia, similar changes were observed in the liver showing slight hepatic necrosis and lymphocyte hyperplasia. The histological changes resemble those produced by chronic ethanol and paracetamol ingestion suggesting the presence of toxic constituents. Hence, the use of S. longepedunculata may be associated with tissue structural damage of some vital organs.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Toxicological Studies of Securidaca longepedunculata on the Heart, Liver, Kidney and Lungs of Rats

Haruna¹

2016

ACT

View full text Add to dashboard Cite

show abstract

“…It is diagnostic of hepatocellular damage, as seen in disorders that might lead to hepatic necrosis such as acute hepatitis and prolonged collapse of the circulatory system (shock) when the liver is deprived of fresh blood bringing oxygen and nutrients [43]. ALP, an ectoenzyme of the hepatocyte plasma membrane, is a "marker" enzyme for the assessment of the integrity of the hepatocyte's plasma membrane [44,45].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activity and toxicological effect of Securidaca longepedunculata (Fresen.) root bark extract in albino rats

Gbadamosi¹,

Adeyi²,

Agbatutu³

2017

Appl Med Res

View full text Add to dashboard Cite

“…In addition to having antiviral properties [4,5], Cucumis metuliferus showed protective effects in the liver and kidney [6]. Securidaca longepedunculata is known to possess a broad spectrum of medicinal, pharmacological and therapeutic properties [7,8]. A search of literature showed that Garcinia kola has no deleterious effect on kidney function but was found to be protective Original Research Article [9].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Some Biochemical Changes in Wistar Rats Following Administration of Three Polyherbal Preparations Repurposed for COVID-19

Amagon

Bukar

Kolawole

et al. 2020

JAMPS

View full text Add to dashboard Cite

Background and Aims: The current pandemic known as Coronavirus Disease-19 (COVID-19) is a significant public health menace. Currently, there is no specific treatment for this disease, although some medicinal agents are under investigation. Some published articles have reported Severe Acute Respiratory Distress Syndrome Coronavirus-2 (SARS CoV-2) involvement in other organs, including the liver and kidneys, which can impair the metabolism and excretion of the medications taken to treat the disease. This study evaluated the effects of 3 herbal mixtures on some biochemical parameters of the liver and kidney of laboratory animals. Methods: Liver enzymes such as serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin and total serum protein were quantified. Urea, creatinine and bilirubin (total and direct) were also evaluated. These parameters were determined for all three polyherbal combinations (CoV Pla-1, CoV Pla-2, CoV Pla-3). Results: The extracts did not produce any mortality up to 5000 mg/kg per oral. Results showed that the polyherbal extracts (CoV Pla-1, CoV Pla-2 CoV Pla-3) did not cause any significant changes in ALT, AST, ALP, compared to control. The mean values of urea showed an insignificant (P>0.05) decrease across all test doses in the three extracts, compared to the control. In the current study, the mean creatinine concentration showed slight decrease across all three extracts. Total protein was observed to be lower in CoV Pla-1 and CoV Pla-2, and increased in CoV Pla-3, though these changes were not statistically significant. Serum albumin decreased at the low and intermediate doses for the three polyherbal extracts in an insignificant manner compared to control. Conclusion: The results obtained in this study indicate that the extracts did not cause significant changes in biochemical parameters evaluated and support their use in the treatment of Covid-19.

show abstract

Evaluation of anti-snake venom activity of the aqueous root extract of <i>Securidaca longipedunculata</i> in rats

Cited by 11 publications

References 0 publications

The Toxicological Studies of Securidaca longepedunculata on the Heart, Liver, Kidney and Lungs of Rats

The Toxicological Studies of Securidaca longepedunculata on the Heart, Liver, Kidney and Lungs of Rats

Anti-inflammatory activity and toxicological effect of Securidaca longepedunculata (Fresen.) root bark extract in albino rats

Assessment of Some Biochemical Changes in Wistar Rats Following Administration of Three Polyherbal Preparations Repurposed for COVID-19

Contact Info

Product

Resources

About