Anti-inflammatory activity and toxicological effect of Securidaca longepedunculata (Fresen.) root bark extract in albino rats

Gbadamosi, Idayat Titilayo; Adeyi, Akindele Oluwatosin; Agbatutu, A

doi:10.5455/amr.20170812063316

Cited by 4 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Violet tree) belongs to the Polygalaceae family, being widely used in traditional African medicine as a supply of local health care [13]. According to scientific reports, this species has relevant applications in ethno-medicine, with multiple indications for human diseases (asthma, hepatic infection, coughs, epilepsy, malaria, tuberculosis, constipation, headache, rheumatism, stomach ache) [5,6,13]. Numerous studies have reported that roots extracts have antimicrobial, antioxidant, antidiabetic, anticonvulsant, anti-inflammatory, antimalarial, insecticidal, pesticidal properties [12,15,16,19].…”

Section: Introductionmentioning

confidence: 99%

Free Radical Scavenging Activity and Total Polyphenol Content of Securidaca Longipedunculata Roots and Leaves Extracts

Obasi¹

2020

FARMACIA

View full text Add to dashboard Cite

Securidaca longipedunculataFresen. is a widely used medicinal plant in most of the African countries. This paper aims to compare the polyphenolic composition and antioxidant activity of some extracts obtained from S. longipedunculata roots and leaves in different solvents: ethanol (E), petroleum ether (PE), ethyl acetate (EtOAc), and water (W). Polyphenols were analysed by spectrophotometric and chromatographic methods. Evaluation of antioxidant activity was performed by several in vitro methods (DPPH bleaching, FRAP, nitrite-induced auto-oxidation of haemoglobin, inhibition of lipid peroxidation catalysed by cytochrome C). Our results revealed that the leaves were abundant in phenolic principles than the roots and the EtOAc was the appropriate solvent for their extraction. The EtOAc extracts exhibited the best antioxidant potential. Several polyphenols were determined in the leaves extracts for the first time: hyperoside, isoquercitrin, rutin, p-coumaric acid. RezumatSecuridaca longipedunculata Fresen. este o plantă medicinală utilizată pe scară largă în majoritatea țărilor africane. Această lucrare își propune să compare compoziția polifenolică și activitatea antioxidantă a unor extracte obținute din rădăcini și frunze de S. longipedunculata în diferiți solvenți: etanol (E), eter de petrol (PE), acetat de etil (EtOAc) și apă (W). Polifenolii au fost analizați prin metode spectrofotometrice și cromatografice. Evaluarea activității antioxidante a fost efectuată prin mai multe metode in vitro (DPPH, FRAP, autooxidarea hemoglobinei indusă de nitriți, inhibarea peroxidării lipidice catalizată de citocromul c). Rezultatele noastre au arătat că frunzele au fost mai bogate în principii fenolice decât rădăcinile, iar acetatul de etil a fost cel mai bun solvent pentru extracție. Extractele în EtOAc au prezentat cel mai bun potențial antioxidant. Polifenolii de tip hiperozidă, izoquercitrină, rutozidă, acid p-cumaric au fost determinați pentru prima dată în extractele obținute din frunze.

show abstract