Evaluation of Anti–Inflammatory, Anti–diabetic activity of Indian Bauhinia vahlii (stembark)

Das, Surya Narayan; Jagannath, Patro Varanashi; Dinda, Subas Chandra

doi:10.1016/s2221-1691(12)60421-3

Cited by 10 publications

(9 citation statements)

References 12 publications

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“…The tribal people of North-Western Himalaya use the leaves of A. bidentata to treat constipation in cattle. B. vahlii has been reported to possess antimicrobial, antiinflammatory, antidiabetic properties (Katyani et al, 2001;Das et al, 2012). The decoction of pods is taken orally in diarrhea and dysentery (Purkayastha et al, 2005).…”

Section: Fig 4 Frequency Of Plant Species Used For the Treatment Ofmentioning

confidence: 99%

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Thakur

Asrani

Thakur

et al. 2016

Journal of Ethnopharmacology

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Section: Fig 4 Frequency Of Plant Species Used For the Treatment Ofmentioning

confidence: 99%

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Thakur

Asrani

Thakur

et al. 2016

Journal of Ethnopharmacology

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“…Among these, B. vahlii root bark extracts displayed acute antihyperglycemic activities in STZ-induced hyperglycemic rats. [14] Beside possible antihyperglycemic activity, extracts from different organs of B. vahlii showed anti-inflammatory, antimicrobial, and strong antioxidant activities. [121314] Flavonoids and triterpenes were identified as the major secondary metabolite in B. vahlii leaves extract.…”

Section: Discussionmentioning

confidence: 99%

“…[14] Results were expressed as gallic acid equivalents (GAE) per milligram of extract through calibration curve plotted using serial dilutions of gallic acid (5–50 μg/ml). The flavonoids content of B. vahlii leaves was assessed spectrophotometrically through complexing reaction with AlC l3 (0.1 M).…”

Section: Methodsmentioning

confidence: 99%

“…The flavonoids content of B. vahlii leaves was assessed spectrophotometrically through complexing reaction with AlC l3 (0.1 M). [14] A standard calibration curve of quercetin was established at a concentration range of 5–50 μg/ml and results were expressed as quercetin equivalents per milligram of the extract.…”

Section: Methodsmentioning

confidence: 99%

“…[13] Previous biological investigations of different organs of B. vahlii identified potential anti-inflammatory, antimicrobial, and antidiabetic effects. [1415] The present study was designed to evaluate possible beneficial effect of B. vahlii leaves extracts in deterring diabetes symptoms and complications in streptozotocin (STZ)-induced diabetic rat model. First, most of the nonpolar secondary metabolites of B. vahlii leaves were extracted using n -hexane to obtain hexane extract (HE), whereas polar metabolites were extracted from the marc by maceration in 70% ethanol to obtain defatted ethanol extract (DEE).…”

Section: Introductionmentioning

confidence: 99%

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Extract of Bauhinia vahlii shows antihyperglycemic activity, reverses oxidative stress, and protects against liver damage in streptozotocin-induced diabetic rats

et al. 2017

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Background:Several studies have affirmed the effectiveness of some Bauhinia plants as antihyperglycemic agents.Objective:We investigated the possible effect of Bauhinia vahlii leaves extract in reducing hyperglycemia and reversing signs of organ damage associated with diabetes in streptozotocin (STZ) rat model.Materials and Methods:Both polar fraction of the B. vahlii leaves (defatted ethanolic extract [DEE]) and nonpolar fraction (n-hexane extract) were evaluated in vitro for α-glucosidase inhibition and 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential. DEE was selected for further in vivo studies and was administered at two doses, i.e., 150 or 300 mg/kg to STZ-diabetic rats for 4 weeks.Results:Only DEE exhibited in vitro antioxidant and antihyperglycemic activities and its oral administration at both dose levels resulted in significant reduction in fasting blood glucose and glycated hemoglobin. Furthermore, signs of oxidative stress as indicated by hepatic reduced glutathione, nitric oxide, and malondialdehyde levels were completely reversed. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of liver pathogenesis when compared to diabetic untreated animals and those treated with metformin. Phytochemical analysis of DEE showed high flavonoids content with quercitrin as the major constituent along with other quercetin glycosides.Conclusion:This study strongly highlights the possible beneficial effect of B. vahlii leaves extract in relieving hyperglycemia and liver damage in STZ-diabetic rats and recommends further investigation of the value of quercetin derivatives in controlling diabetes and ameliorating liver damage associated with it.SUMMARY The polar fraction of the Bauhinia vahlii leaves (defatted ethanolic extract [DEE]) exhibited both in vitro antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging assay and strong α-glucosidase inhibition while the nonpolar fraction (n-hexane extract) failed to show any activity in both assays. DEE was further investigated in streptozotocin-induced diabetic rat model where oral administration of DEE at 2 doses (150 and 300 mg/kg) for 4 weeks resulted in significant reduction in fasting blood glucose and glycated hemoglobin and reversal of oxidative stress signs as indicated by measurement of hepatic reduced glutathione, nitric oxide, and malondialdehyde levels. In addition, histopathological examination and measurement of serum aspartate transaminase and alanine transaminase levels showed that DEE protected the liver from signs of pathogenesis observed in diabetic untreated rats. Phytochemical analysis of DEE showed high flavonoid content with quercitrin as the major constituent (62.9 ± 0.18 mg/mg). Abbreviations used: ALT: Alanine transaminase, AST: Aspartate transaminase, DEE: Defatted ethanol extract, DPPH: 2,2-diphenyl-1-picrylhydrazyl, FBG: Fasting blood glucose, GAE: Gallic acid equivalent, GSH: Reduced glutathione, Hb1Ac: Glycat...

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A validated phytochemical marker based HPTLC method for the segregation of Bauhinia vahlii Wight and Arn. from geologically different samples of Indian zones

Sharma,

Mishra,

Khan

et al. 2024

JPC-J Planar Chromat

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Evaluation of Anti–Inflammatory, Anti–diabetic activity of Indian Bauhinia vahlii (stembark)

Cited by 10 publications

References 12 publications

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Extract of Bauhinia vahlii shows antihyperglycemic activity, reverses oxidative stress, and protects against liver damage in streptozotocin-induced diabetic rats

A validated phytochemical marker based HPTLC method for the segregation of Bauhinia vahlii Wight and Arn. from geologically different samples of Indian zones

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