Evaluation of anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) extract in laboratory animals

Abstract

Context:Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) is a diffuse herb with prickly stem, traditionally used for the treatment of inflammation and one in the group of daśamūla (group of ten herbs) herbs commonly used drug in Ayurveda.Aims:In continuation of search for potent natural anti-inflammatory agents, the present research work was planned to evaluate the anti-inflammatory activity of ethanol extract of S. xanthocarpum whole plant.Settings and Design:The ethanol extract was evaluated at dose 10, 30 and 100 mg/kg p.o. in rats.Materials and Methods:Using pharmacological screening models carrageenan induced rat paw edema, histamine induced rat paw edema and cotton pellet granuloma in rats.Statistical Analysis Used:Data obtained was analyzed statistically using analysis of variance followed by post-hoc Dunnett test, P < 0.05 is considered as statistically significant.Results:Acute treatment didn’t show anti-inflammatory activity against carrageenan and histamine induced paw edema. However, administration of 100 mg/kg p.o for 7 day reduced the granuloma formation in cotton pellet granuloma model.Conclusions:Present results support the traditional use of plant for anti-inflammatory activity. In brief, the results provide scientific pharmacological basis for the therapeutic use of S. xanthocarpum.

Interactive Effects of Wide-Spectrum Monochromatic Lights on Phytochemical Production, Antioxidant and Biological Activities of Solanum xanthocarpum Callus Cultures

“…These results are the first study documenting the effects of light on anti-inflammatory activity of extracts from S. xanthocarpum callus cultures. Although, anti-inflammatory activity form crude extract of wild plant has previously been studied in vivo and in vitro [10,11]. The effects of light on anti-inflammatory activity of extracts from in vitro cultures of S. marianum have been reported [38], thus confirming the feasibility of the production of anti-inflammatory compounds using plant in vitro biotechnological systems.…”

“…Inflammation is the local vascularized or immune response to harmful stimuli, pathogens, and irritants. Based on its traditional usages, anti-inflammatory action of S. xanthocarpum has been proposed [11,41]. Phenylpropanoids are one of the important classes of plants secondary metabolites that are involved in anti-inflammatory activities of plant extracts in relation with their capacity to inhibit key enzymes involved in inflammation process [38].…”

“…Its fruits, edible yellow berries surrounded by enlarged calyx, are largely used as traditional medicine to cure various ailments. Several biological activities relevant with their traditional uses have been reported, including antioxidant [5][6][7], anti-diabetic [8,9], anti-inflammatory [10,11], as well as effects on skin appearance [12]. Phytochemical profiling of S. xanthocarpum extracts revealed the presence of diverse classes of bioactive secondary metabolites including alkaloid glycosides [13,14], saponins [15,16], but also of high levels of coumarins [17], in particular of scopoletin and esculetin ( Figure 1).…”

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects ofSolanum virginianumin Rats

“…30 It comprises numerous remedial constituents such as glycosides, anthraquinones, flavonoids, sterols, saponins and alkaloids. 31 This traditionally used medicinal herb has been reported to own cardio-protective, 32 hepatoprotective, 33 antidiabetic, 34 anti-asthmatic, 35 anti-inflammatory 36 and anti-cancer properties. 37 The current study was intended to explore pharmacologically important constituents in the methanolic extract of S. virginianum (SV.CR) through a set of in-vitro experimentation.…”

The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats

“…14 , 15 Plants are very useful in curing many diseases and for hygiene via producing secondary metabolites like proteins, alkaloids, steroids, flavonoids, and phenolic compounds. 16 , 17 …”