The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats

Abstract

This study was conducted to evaluate the prophylactic effect of ginger extract on ethanol-induced reproductive toxicity in male rats. Twenty-eight adult male Sprague-Dawley rats were randomly divided into 4 groups and treated daily for 28 days as follows: control, control-ginger (1 g/kg of body weight [BW]/day by gavage), ethanol group (ethanol 4 g/kg of BW/day by gavage), and ginger-ethanol group. At the end of the experiment, all the rats were sacrificed and their testes were removed and used for measurement of the total homocysteine (tHcy), trace elements, antioxidant enzymes activity, and malondialdehyde (MDA). The results in the ethanol group indicate that ethanol decreased antioxidant enzymes activity and increased MDA and tHcy compared with the control groups (P < .05). In ginger-ethanol group, ginger improved antioxidant enzymes activity and reduced tHcy and MDA compared to ethanol group (P < .05). It can be concluded that ginger protects the ethanol-induced testicular damage and improves the hormonal levels, trace elements, antioxidant enzymes activity, and decreases tHcy and MDA.

The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

“…Many studies believed that taking zinc supplements and ginger could improve metabolic disorders such as obesity, DM, and MS by several mechanisms (Li, Tran, et al., 2012; Miao et al., 2013; Ruz et al., 2019; Wang et al., 2017, 2019). Ginger improves metabolic disorders by increasing the thermogenesis, the energy expenditure, the lipolysis, and by inhibiting the lipogenesis and the lipid accumulation and the intestinal absorption of dietary fat (Akbari et al., 2017, 2019; Ebrahimzadeh Attari et al., 2018; Li, Tran, et al., 2012; Maharlouei et al., 2019; Wang et al., 2017; Zhu et al., 2018). In addition, it was reported that ginger prevents obesity through the regulation of energy metabolism and activation of browning in HFD‐induced obese mice (Wang et al., 2019).…”

“…In addition, it was reported that ginger prevents obesity through the regulation of energy metabolism and activation of browning in HFD‐induced obese mice (Wang et al., 2019). Moreover, it plays a key role in controlling appetite (Mansour et al., 2012) and homeostasis of some essential elements such as zinc (Akbari et al., 2017). Okamoto et al.…”

Does Ginger Protect Against Ovarian Damage in Rats Induced by Sodium Metabisulfite Toxicity? An Experimental Evidence

“…Previous studies have shown that natural antioxidants have great potential for protecting DNA and other biomolecules from damages caused by oxidation [10,11]. Ginger (Zingiber officinale) with a wide range of biological properties contains high amount of antioxidants, such as gingerol and shogaol [12,13]. Ginger has been shown to lower lipid peroxidation by maintaining antioxidant enzymes activities and increasing glutathione level in the rat blood [14].…”

Efficacy of topical Citrullus colocynthis (bitter apple) extract oil in chemotherapy‐induced peripheral neuropathy: A pilot double‐blind randomized placebo‐controlled clinical trial

“…Antioxidant assay of C . colocynthis was carried out according to the DPPH (2,2‐diphenyl‐1‐picryl‐hydrazyl‐hydrate) methods described earlier (Akbari, Nasiri, Heydari, Mosavat, & Iraji, ). DPPH is a stable free radical with purple color, which demonstrates a strong absorption at 517 nm.…”