2019
DOI: 10.1039/c9md00276f
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Evaluation of anti-inflammatory activity and molecular docking study of new aza-bicyclic isoxazoline acylhydrazone derivatives

Abstract: The aim of this study was to investigate the anti-inflammatory effects of two new isoxazoline-acylhydrazone derivatives.

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Cited by 17 publications
(9 citation statements)
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“…The most common anti-inflammatory cytokines are interleukins IL-4, IL-10, IL-13, and TGFβ (transforming growth factor). The most common proinflammatory cytokines are tumor necrosis factor (TNF), and interleukins IL-1, IL-2, IL-6 and IL-7 [ 5 , 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…The most common anti-inflammatory cytokines are interleukins IL-4, IL-10, IL-13, and TGFβ (transforming growth factor). The most common proinflammatory cytokines are tumor necrosis factor (TNF), and interleukins IL-1, IL-2, IL-6 and IL-7 [ 5 , 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…The Ximenes research group investigated the anti‐inflammatory effects of isoxazoline acylhydrazone ( 16 , 17 ) and interestingly, they were found to be potent inhibitors of the histamine H1 receptor. Furthermore, monitoring compounds 16 and 17 showed a substantial decrease in the production of cytokine levels (TNF‐α and IL‐1β) with 271.60 and 305.88 pg mL −1 in comparison with reference drug indomethacin (TNF‐α=425.17 pg mL −1 ; IL‐1β=564.06 pg mL −1 ) [89] . Park et al.…”
Section: Pharmacological Profile Of Isoxazoline Derivativesmentioning
confidence: 96%
“…Indolecarboxamides were reported to form hydrogen bonds with N443 ECL3 , R176 ECL2 , and I 6.58 [ 65 ] while alkyl/aryl piperidyl indole formed electrostatic interactions with conserved Y 6.51 residue [ 69 ]. Several other compounds have been docked to the H 1 R structure such as aminomethylenepyrimidine-2,4,6-triones, N 1 -alkyltheobromine, N-methylanthranilates, azabicyclic isoxazoline acylhydrazones, substituted tetrazole-incorporated quinoline derivative, synthesized rupatadine and desloratadine analogues [ 70 , 73 , 76 , 105 ]. Elbayaa [ 70 ] designed a series of substituted aminomethylenepyrimidine-2,4,6-trione derivatives generated from a four-featured pharmacophore model with an aromatic or π-ring system, hydrophobic group, a H-bond donor and a H-bond acceptor group derived from five H 1 R antagonists and validated this model using six other H 1 R antagonists.…”
Section: Hr-targeted Ligands and Receptor Binding Site Of Inactivementioning
confidence: 99%