2007
DOI: 10.1016/j.jep.2007.01.019
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Evaluation of anti-diarrhoeal and anti-ulcerogenic potential of ethanol extract of Carpolobia lutea leaves in rodents

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Cited by 31 publications
(36 citation statements)
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“…Indomethacin is known to cause ulcer especially in an empty stomach and mostly on the glandular (mucosal) part of the stomach by inhibiting prostaglandin synthetase through the cycloxygenase pathway [13] . Prostaglandins function to protect the stomach from injury by stimulating the secretion of bicarbonate and mucus, maintaining mucosal blood flow and regulating mucosal turn over and repair [17] .…”
Section: Discussionmentioning
confidence: 99%
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“…Indomethacin is known to cause ulcer especially in an empty stomach and mostly on the glandular (mucosal) part of the stomach by inhibiting prostaglandin synthetase through the cycloxygenase pathway [13] . Prostaglandins function to protect the stomach from injury by stimulating the secretion of bicarbonate and mucus, maintaining mucosal blood flow and regulating mucosal turn over and repair [17] .…”
Section: Discussionmentioning
confidence: 99%
“…The extract was observed to significantly reduce mucosal damage in the indomethacin-induced ulcer model, suggesting the possible extract mobilization and involvement of prostaglandin in the anti-ulcer effect of the extract. Administration of ethanol has been reported to cause disturbances in gastric secretion, damage to the mucosa, alterations in the permeability, gastric mucus depletion and free radical production [13] . It was observed in this study that the extract significantly reduced ethanolinduced ulcer.…”
Section: Discussionmentioning
confidence: 99%
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