Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models

Nwidu, Lucky Legbosi; Nwafor, Paul A.; Silva, Viviane Cândida da; Rodrigues, Clenilson Martins; Santos, Lourdes Campaner dos; Vilegas, Wagner; Nunes-de-Souza, Ricardo Luiz

doi:10.1007/s10787-010-0076-y

Cited by 18 publications

(20 citation statements)

References 25 publications

(27 reference statements)

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“…Polyphenols have been isolated from the leaf of C. lutea (Nwidu et al, 2011). It has been suggested that polyphenols are responsible for the antibacterial effects upon Streptococcus mutans (Kakiuchi et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of <i>Carpolobia lutea</i> extracts and fractions

Nwidu¹,

Nwafor²,

Vilegas³

2012

Afr. J. Trad. Compl. Alt. Med.

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Carpolobia lutea (G. Don) (Polygalaceae) is a tropical medicinal plant putative in traditional medicines against gonorrhea, gingivitis, infertility, antiulcer and malaria. The present study evaluated the antimicrobial, antifungal and antihelicobacter effects of extracts C. lutea leaf, stem and root. The extracts were examined using the disc-diffusion and Microplates of 96 wells containing Muller-Hinton methods against some bacterial strains: (ATCC 43504). Some of these extracts were found to be active against some tested strains but activity against H. pylori was >1000mg/ml and good fungistatic activity against C. albican. The MIC against C. albican is in the order n-HF > CHF > ETF= EAF.The order of potency of fraction was the ethanol root > n-HF leaf > ethanol fraction stem > chloroform fraction leaf = ethyl acetate fraction leaf. Polyphenols were demonstrated in ethanol fraction, ethyl acetate fraction, crude ethyl acetate extract and ethanol extract, respectively. These polyphenols isolated may partly explain and support the use of C. lutea for the treatment of infectious diseases in traditional Ibibio medicine of Nigeria.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of <i>Carpolobia lutea</i> extracts and fractions

Nwidu¹,

Nwafor²,

Vilegas³

2012

Afr. J. Trad. Compl. Alt. Med.

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“…Moreover, it is important to state that 770 mg/kg dose of EAF reduced ulcer index comparable to the standard drug, cimetidine (100 mg/kg). At that same dose of the fraction in another study, the intestinal propulsive movements (IPM) in rat was inhibited by 100% through α 2 -adrenergic mechanism (Nwidu et al, 2011). Thus the possible mechanism of antiulcer activity may not be unrelated with the inhibition muscarinic receptors in the parietal cells.…”

Section: Dietary Polyphenols Has Protective Effects Against Various Dmentioning

confidence: 91%

“…All the doses of EAF utilised in the experiment were very effective than the 30 mg/kg omeprazole. At a critical dose of 770 mg/kg, the same dose that gave 100% inhibition of intestinal transit (Nwidu et al, 20011), the ulcers induced by ethanol were protected 100%. The low RSA may preclude DPPH assay as a possible mechanism of elucidating its antioxidant effects.…”

Section: Dietary Polyphenols Has Protective Effects Against Various Dmentioning

confidence: 99%

“…Cinnamic acid and p-coumaric acid antiulcer effects have been demonstrated (Frey et al, 2001;Pereira et al, 2003;Funari et al, 2007;Siddaraju and Shylaja, 2007;Barros et al, 2008). Two new cinnamoyl 1-deoxyglucosides, cinnamic acid, besides two new coumaroyl 1-deoxyglucosides, were isolated by semi-preparative HPLC and the structures was established using NMR experiments Nwidu et al, 2011. This study quantitatively isolate, elucidate the active compounds from the EAF by semi-preparative HPLC and subjecting the fraction to radical scavenging assays (RSA). The total phenolic content (TPC) was also quantified.…”

Section: Introductionmentioning

confidence: 99%

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Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

Nwidu¹

2012

J. App. Pharm. Sci.

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Carpolobia lutea leaves (CLL) (Polygalaceae) were earlier screened and the antiulcer ethnomedicinal claim established. This article seeks to quantitatively isolate, elucidate the active compounds from most active CLL fraction. Fractionation was by semi-preparative HPLC; the active fraction was subjected to radical scavenging assays (RSA) and quantification of the total phenolic content (TPC) were also executed. Results: Ethyl acetate fraction (EAF) was observed to be the most pharmacologically active antiulcer fraction when screened using acute ulcer models induced in rodents. The EAF demonstrated significant (p < 0.05-0.001) antiulcer activity in various in vivo induced ulceration models by reducing the ulcer index and increasing the preventive ratio. The EAF demonstrated > 70% in TPC and < 20 % in RSA. Cinnamic and coumaric acids derivatives were isolated from EAF. Cinnamic acids have been implicated and patented as antiulcer agent. Isolated compounds could in part mediate the observed pharmacological activities which lend credence to its ethnobotanical uses.

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“…This trails and camps created by tradesmen form openings for poachers and other NTFPs users. The tradesmen embark on continuous harvest without planting and through this means have endangered the species that is traditionally used for the treatment of various ailments (Burkill, 1985;Mitaine-offer et al, 2002;Nwidu and Nwafor, 2009;Okokon et al 2011;Bero et al, 2011;Jackson et al, 2011; www.ccsenet.org/ijb Nwidu et al, 2011;Idowu et al, 2005;Ettebong and Nwafor, 2009;Ajiwhen and Bisong, 2013), including memory enhancement and madness. A typical stick is taken away from the forest at economic worth of N150.00 (One hundred and fifty naira).…”

Section: Poaching Of Ntfps In Crnp and Its Ecological Consequenciesmentioning

confidence: 99%

Forms and Trends of Encroachments in Cross River National Park of Nigeria

Ijeomah¹,

Eniang²,

Halidu³

et al. 2015

IJB

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Forms and trends of encroachments were investigated in Cross River National Park (CRNP) of Nigeria with the view of ascertaining the prevailing forms, trends, strategies of poaching and ecological consequences of illegal exploitations on the state of species in the biodiversity hotspot; that is contiguous with Korup and Takamanda national parks of Cameroon. Data for this study were obtained through personal observations, administrative record, structured questionnaires and in depth interview with experienced members of park protection staff who have been in the park for a minimum period of five years and are therefore quite knowledgeable about wildlife management and protection in the park. A set of questionnaire was randomly administered to 40 Park protection staff of CRNP in other to examine the forms, trends, intensity and reasons for encroachment in the park. Data on trend of arrest being an indicator of encroachment was collected from the administrative record of CRNP. Data obtained were analyzed using descriptive statistics in form of percentages and frequency of counts. Hunting (100%) and collection of Non Timber Forest Products (NTFPs) (75%) were implicated as the highest form of encroachment in the park while fuel wood collection (15%) was the least. The highest and lowest forms of arrest between 1991 and 2014 were 12.8% and 0.2% respectively. The least annual arrest (0.2%) recorded between 1991 and 2014 was in 1994 and 1995 respectively. Out of 616 arrests made between 1991 and 2014 34.%, 28.9% and 26.1% were for logging, hunting and collection of NTFPs respectively while aiding and abetting had the least record of only 1.6%. Nevertheless most respondents implicated households of host and enclave communities as encroachers (85.00%) and aiders of encroachments (95.0%) in CRNP. Cross River National Park is porous to non-seasonal encroachment as the anti poaching operations therein are ineffective.

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Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models

Cited by 18 publications

References 25 publications

Antimicrobial activity of <i>Carpolobia lutea</i> extracts and fractions

Antimicrobial activity of <i>Carpolobia lutea</i> extracts and fractions

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

Forms and Trends of Encroachments in Cross River National Park of Nigeria

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