Essential Oil of Carpolobia lutea

Ogunwande, Isiaka A.; Flamini, Guido; Avoseh, Opeyemi N.; Banwo, Inumidun D.

doi:10.1007/s10600-014-0958-0

Cited by 6 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The leaf of C. lutea contains essential oil rich in terpenoids, hexahydro farnesyl acetone, (E)-geranyl acetone, (E)-2-decenal, farnesyl acetone, germacrene B, and α-calacorene [29]. Also, 2 new polyphenols namely; cinnamonyl 1-deoxy-glucopyranosides and 2 new p-coumaroyl 1-deoxy-glucopyranosides together with cinnamic acid were isolated from the ethyl acetate fraction of leaf of C. lutea (a fraction reported to possess strong antidiarrheal activity) [12].…”

Section: Discussionmentioning

confidence: 99%

Carpolobia lutea G. Don (Polygalaceae) Inhibits Inflammation and Oxidative Stress in an Acetic Acid Induced Model of Rat Colitis

Abiodun

Oshinloye

2016

Drug Res (Stuttg)

View full text Add to dashboard Cite

G. Don (CL) is used in folk medicine for the treatment of inflammatory disorders. Effort in this study is to evaluate the beneficial effect of the aqueous-methanol extract of leaf of CL in a rat model of acetic acid induced colitis. Male Wistar rats were distributed into 6 groups of 7 rats each; non colitic, untreated colitic and colitic rats treated with graded doses of CL (100-800 mg/kg). Rats were pre-treated for 2 days before colitis induction and thereafter for 7 days post colitic induction. 24 h after the last treatment, animals were sacrificed and colonic inflammation was evaluated both macroscopically and biochemically. Macroscopic damage score, weight/length ratio, myeloperoxidase (MPO) activity and tumor necrotic factor alpha (TNF-α) levels, were significantly higher in untreated colitic rats in comparison with non colitic rats (P<0.05). Treatment with CL significantly reduced the macroscopic damage scores, neutrophil infiltration (MPO activity) and TNF-α level (P<0.05). In addition, significantly prevented depletion of colonic GSH and (SOD) levels (P<0.05). It appears that the beneficial effect of methanol extract of leaf observed in this study is dose dependent and is related to its antioxidant and anti-inflammatory activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Carpolobia lutea G. Don (Polygalaceae) Inhibits Inflammation and Oxidative Stress in an Acetic Acid Induced Model of Rat Colitis

Abiodun

Oshinloye

2016

Drug Res (Stuttg)

View full text Add to dashboard Cite

show abstract

“…[ 17 ] However, aphrodisiac activity was revealed with polyphenols isolated from Mimosa pudica and Cydonia oblonga . [ 64 65 66 ] Recently, several terpenoids have been hydrodistilled from the leaf of CL[ 7 ] The reviewed bioactivity of terpenoids encompasses: cancer chemopreventive, antimicrobial, antifungal, antiparasitic, antiviral, anti-allergenic, antileishmanial, antispasmodic, antihyperglycemic, anti-inflammatory, immunomodulatory, insecticidal, and cytotoxic properties. [ 67 68 69 ]…”

Section: Discussionmentioning

confidence: 99%

“…The hydrodistillation of the leaf using a Clevenger-type apparatus afforded a yield of essential oil (0.06-0.10%), which contained terpenoids, hexahydro farnesyl acetone, (E)-geranyl acetone, (E)-2-decenal, farnesyl acetone, germacrene B, and α-calacorene. [ 7 ] Chromatographic fractionation of the ethyl acetate fraction (EAF) afforded two new cinnamonyl 1-deoxy-glucopyranosides (1 and 2) and two new p -coumaroyl 1-deoxy-glucopyranosides (4 and 5), besides cinnamic acid (3) [ Figure 2 ]. [ 17 ] Three new acetylated triterpene saponins were isolated from the roots of CA and CL.…”

Section: Geographical Distributionmentioning

confidence: 99%

See 1 more Smart Citation

The aphrodisiac herb Carpolobia: A biopharmacological and phytochemical review

2015

View full text Add to dashboard Cite

Any agent with the ability to provoke sexual desire in an individual is referred to as an aphrodisiac. Aphrodisiac plants are used in the management of erectile dysfunction (ED) in men. One such plant popular in West and Central Africa among the Pygmies of Cameroon, Ipassa of Garbon, and the Yoruba, Ibo, Efik and Ijaw peoples of Nigeria is Carpolobia. It is an accepted and commonly utilized herbal booster of libido. It is used to cure male infertility and to boosts libido thereby augmenting male sexual functions or it is used to induce penile erection, and enhance male virility. The chewing stick prepared from the stem and root of either Carpolobia alba (CA) or Carpolobia lutea (CL) is patronized because it boosts male sexual performance. The genus Carpolobia has over 14 species. The leaf essential oil contains a variety of terpenoids, while polyphenols and triterpenoid saponins have been isolated from the root and leaf extracts respectively. Other ethnomedicinal uses include curing of stomach ailments, rheumatism, fever, pains, insanity, dermal infection, venereal diseases; to promote child birth; and as a taeniafuge and vermifuge. In spite of its popularity, no scientific data reviewing the biopharmacological and phytochemical activities of Carpolobia exist to our knowledge. The aim of this work is to collate all available published scientific reports in the literature on Carpolobia in a review paper. In this review, an overview of the morphology, taxonomy, ethnomedicinal claims, geographical distribution, and structurally elucidated compounds that are secondary metabolites isolated and characterized from Carpolobia species is established. The pharmacological assays, phytochemical screenings, and toxicological reports are also reviewed.

show abstract

“…Carpolobia lutea G. Don (Family: Polygalaceae), a small tree growing up to 15ft in height (Akpan et al, 2012) is wide spread across the west and central areas of tropical Africa (Mitaine-offer et al, 2002;Nwidu et al, 2015). The common names include cattle stick (English); ikpafum, ndiyan, nyayanga (Ibibio); abekpok ibuhu (Eket); agba, angalagala (Igbo); egbo oshunshun (Yoruba); (Kayode and (Kayode and Omotoyinbo, 2008;Ogunwande et al, 2014). The plant has been scientifically validated to have the following medicinal effects: analgesic (Ajibesin et al, 2008, Jackson et al, 2011, protection of the GIT (Nwidu and Nwafor, 2009), antidiarrheal (Nwidu et al, 2014), anti-diarrhoeal and treatment of ulcer (Nwafor and Bassey, 2007), antimicrobial (Ettebong and Nwafor, 2009), aphrodisiac (Mitaine-Offer et al, 2002), antimalarial (Okokon et al, 2011), contraceptive (Ettebong et al, 2011), antidiabetic and hypolipidemic (Akpan et al, 2012), acute and subacute toxicity (Nwidu et al, 2012), antiacetylcholinesterase activity and antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium-challenged rats

Eze¹,

Nwaka²,

Vincent³

et al. 2019

J. Physiol. Pathophysiol.

View full text Add to dashboard Cite

Cadmium produces a wide range of biological dysfunctions in human and laboratory animals where it chiefly affects the testes, whereas, Carpolobia lutea has been known to have antioxidant benefits. This study was intended to investigate the effects of Carpolobia lutea root extracts on testicular hormone function in cadmium-challenged male rats. 48 male Wistar rats (170-190 g) were divided into six groups, each containing eight rats. Experimental animals in control (Group 1) were given 0.2ml/kg body weight (BW) of 10% tween 80; Group two were administered 1mg/kg BW of cadmium (i.p); Group 3 were given 1mg/kg BW of cadmium (i.p) + 100mg/kg BW extract; Group four took 1mg/kg BW of cadmium (i.p) + 200mg/kg BW extract while Group five and six got 100mg/kg and 200mg/kg BW extract respectively. The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 betahydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. Findings indicated that cadmium statistically (p<0.05) lowered testicular 17β-HSD activity and serum testosterone, LH and FSH levels when compared with those of the control group animals. However, Carpolobia lutea and its co-administration notably (p<0.05) elevated the activity of testicular 17β-HSD and levels of serum testosterone, LH and FSH. The study suggests that Carpolobia lutea extract plays a protective function in ameliorating testicular damage caused by cadmium in rats. This is probably due to the extract's potential in the management of testicular dysfunction and fecundity in animals.

show abstract

Essential Oil of Carpolobia lutea

Cited by 6 publications

References 8 publications

Carpolobia lutea G. Don (Polygalaceae) Inhibits Inflammation and Oxidative Stress in an Acetic Acid Induced Model of Rat Colitis

Carpolobia lutea G. Don (Polygalaceae) Inhibits Inflammation and Oxidative Stress in an Acetic Acid Induced Model of Rat Colitis

The aphrodisiac herb Carpolobia: A biopharmacological and phytochemical review

Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium-challenged rats

Contact Info

Product

Resources

About