Evaluation of an International Pharmacopoeia method for the analysis of indinavir sulfate by liquid chromatography

LC Assay for a HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate and Rilpivirine

“…[13][14][15]. For method development the reference solution containing the three active compounds was used.…”

Evaluation of an International Pharmacopoeia method for the analysis of saquinavir (mesilate) bulk drugs by liquid chromatography

“…the distance between the baseline and a line connecting the two peak apexes, at the location of the valley) and f is the depth of the valley, measured from the line connecting two peak apexes [14][15][16] (Fig. 3(A)).…”

“…Therefore, it was decided to examine the separation on a set of 18 columns, available in our laboratory and which are at least either base-deactivated or end-capped (the latter were included to check their performance). The columns were chosen based on a column ranking system developed in our laboratory [9][10][11][12][13][14][15][16] and which is also freely accessible on our website [17]. The ranking system is based on the determination of 4 chromatographic parameters.…”

“…The quality of the separations was expressed by the CRF-values. In previous correlation experiments, three arbitrarily chosen ranges of CRF values were distinguished: F < 2, 2 < F < 6, F > 6 [14][15][16].…”

“…Since no brand names are mentioned in the monograph, the suitability of a set of 18 columns, all complying to the prescriptions of the monographs, was investigated towards the separation of SQV(M) and its impurities. It was checked whether a correlation could be made with the column classification system developed in our laboratory [9][10][11][12][13][14][15][16][17].…”