Evaluation of an International Pharmacopoeia method for the analysis of saquinavir (mesilate) bulk drugs by liquid chromatography

A liquid chromatographic method with UV detection was developed for the assay of a tablet for HIV (human immunodeficiency virus) treatment containing three active components, which are emtricitabine, tenofovir disoproxil fumarate and rilpivirine. A Hypersil BDS-C18 column was used as stationary phase and the assay was performed with gradient elution using mobile phases containing acetonitrile, 0.2 M potassium dihydrogen phosphate and water. Dimethyl sulfoxide-distilled water (1:1) was used as solvent for the active components. The method proved to be selective, linear, repeatable, sensitive and easy to perform.

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“…[13][14][15]. For method development the reference solution containing the three active compounds was used.…”

Section: Methods Developmentmentioning

confidence: 99%

LC Assay for a HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate and Rilpivirine

et al. 2011

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“…As in previous studies, three arbitrarily chosen ranges of F-values were distinguished for the columns in Table 1: F < 2, 2 < F < 6 and F > 6 [7][8][9][10][11][12].…”

Section: Correlation Between the Column Classification And The Separamentioning

confidence: 99%

“…New preparations were made and analyzed on each of three successive days. An intermediate precision study was performed as described in [10][11][12]. The results are summarized in Table 2.…”

Section: Quantitative Aspects 3321 Precision Linearity and Sensimentioning

confidence: 99%