Evaluation of an adequate method of estimating flowability according to powder characteristics

Antequera, M. V. Velasco; Muñoz‐Ruiz, Angel; Perales, Manuel; Muñoz, Nydia; Ballesteros, María Rosa Jiménez-Castellanos

doi:10.1016/0378-5173(94)90096-5

Cited by 28 publications

(26 citation statements)

References 9 publications

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“…In contrast, other researchers have suggested that angle of repose is a poor measure of powder¯ow (Amidon & Houghton 1985 ;Fassihi & Kanfer 1986 ;Munoz-Ruiz et al 1993a, b ;Antequera et al 1994). Angle of repose measurements may only be used for free-¯owing powders (Newton 1987) and are believed to lack su cient sensitivity and reproducibility to discriminate between broadly similar powders (Amidon & Houghton 1985).…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 88%

“…A drawback of the shear-cell approach is the wide variety of methods and shear-cell apparatus available, which can lead to variability and lack of correlation between measurements (Antequera et al 1994). For example, Ramachandruni & Hoag (2001) demonstrated that instrument and process parameters can signi® cantly aOE ect the results obtained.…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

“…Munoz-Ruiz et al (1993a, b) showed that mass¯ow rate through a hopper could be used to predict the weight uniformity of maltodextrin tablets and correlated well with compressibility index values. Antequera et al (1994), Velasco et al (1995) and Dahlinder et al (1982) found that minimum blocking aperture and mass¯ow rate were predictive of tablet weight uniformity. However, Doelker (1993) suggested that mass¯ow rate was a poor predictor of tablet weight uniformity and lacked correlation with compressibility indices.…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

“…Carr' s index, Hausner ratio and the angle of internal ow have been used to predict tablet and capsule weight uniformity with varying degrees of success (Nyqvist & Nicklasson 1985 ;Fassihi & Kanfer 1986 ;Newton & Bader 1987 ;Tan & Newton 1990a ;Munoz-Ruiz et al 1993a, b ;Antequera et al 1994 ;Amidon & Houghton 1995 ;Podczeck & Newton 1999). While compressibility indices appear more predictive than angle of repose measurements (Amidon & Houghton 1995), there are several instances where the correlation with dosage-form weight uniformity has been poor (Doelker 1993 ;Podczeck & Newton 2000).…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

“…However, Doelker (1993) suggested that mass¯ow rate was a poor predictor of tablet weight uniformity and lacked correlation with compressibility indices. A limitation of this technique is that it is only suitable for measuring free¯owing powders (Newton 1987 ;Antequera et al 1994).…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

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Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

Hardy

Cook

2003

Journal of Pharmacy and Pharmacology

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There is much interest in predicting the properties of pharmaceutical dosage forms from the properties of the raw materials they contain. Achieving this with reasonable accuracy would aid the faster development and manufacture of dosage forms. A variety of approaches to prediction or correlation of properties are reviewed. These approaches have variable accuracy, with no single technique yet able to provide an accurate prediction of the overall properties of the dosage form. However, there have been some successes in predicting trends within a formulation series based on the physicochemical and mechanical properties of raw materials, predicting process scale-up through mechanical characterisation of materials and predicting product characteristics by process monitoring. Advances in information technology have increased predictive capability and accuracy by facilitating the analysis of complex multivariate data, mapping formulation characteristics and capturing past knowledge and experience.

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Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 88%

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%