Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor

Ito, Maiko; Shien, Tadahiko; Omori, Masako; Mizoo, Taeko; Inomata, Takayuki; Nogami, Tomohiro; Motoki, Takayuki; Taira, Naruto; Doihara, Hiroyoshi; Miyoshi, Shinichiro

doi:10.1007/s12282-015-0583-1

Cited by 21 publications

(21 citation statements)

References 25 publications

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“…CSCs may be responsible for the resistance of chemotherapy, which leads to relapse and multidrug resistance in cancer disease . Currently, the evaluation of CD44, CD24 and ALDH1 expressions is considered as the most precise methodology to identify CSCs in the breast cancer women . Recently, both CD24 and CD44 have been proven as good CSCs markers in chemocarcinogen‐induced rat mammary tumorigenesis .…”

Section: Discussionmentioning

confidence: 99%

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

Kubatka

Uramova

Kello

et al. 2017

J Cellular Molecular Medi

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It is supposed that plant functional foods, rich in phytochemicals, may potentially have preventive effects in carcinogenesis. In this study, the anticancer effects of cloves in the in vivo and in vitro mammary carcinoma model were assessed. Dried flower buds of cloves (CLOs) were used at two concentrations of 0.1% and 1% through diet during 13 weeks after the application of chemocarcinogen. After autopsy, histopathological and immunohistochemical analyses of rat mammary carcinomas were performed. Moreover, in vitro evaluation using MCF‐7 cells was carried out. Dietary administered CLO caused the dose‐dependent decrease in tumour frequency by 47.5% and 58.5% when compared to control. Analysis of carcinoma cells in animals showed bcl‐2, Ki67, VEGFA, CD24 and CD44 expression decrease and Bax, caspase‐3 and ALDH1 expression increase after high‐dose CLO administration. MDA levels were substantially decreased in rat carcinomas in both CLO groups. The evaluation of histone modifications revealed increase in lysine trimethylations and acetylations (H4K20me3, H4K16ac) in carcinomas after CLO administration. TIMP3 promoter methylation levels of CpG3, CpG4, CpG5 islands were altered in treated cancer cells. An increase in total RASSF1A promoter methylation (three CpG sites) in CLO 1 group was found. In vitro studies showed antiproliferative and pro‐apoptotic effects of CLO extract in MCF‐7 cells (analyses of cytotoxicity, Brdu, cell cycle, annexin V/PI, caspase‐7, Bcl‐2 and mitochondrial membrane potential). This study showed a significant anticancer effect of clove buds in the mammary carcinoma model in vivo and in vitro.

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Section: Discussionmentioning

confidence: 99%

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

Kubatka

Uramova

Kello

et al. 2017

J Cellular Molecular Medi

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“…For example, TWIST1 expression is associated with poor prognosis in patients with ER+ breast cancer41 and primary breast cancer42. The Zhang P. et al .…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis

Imani

Hosseinifard

Cheng

et al. 2016

Sci Rep

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The epithelial-to-mesenchymal transition (EMT) is a vital control point in metastatic breast cancer (MBC). TWIST1, SNAIL1, SLUG, and ZEB1, as key EMT-inducing transcription factors (EMT-TFs), are involved in MBC through different signaling cascades. This updated meta-analysis was conducted to assess the correlation between the expression of EMT-TFs and prognostic value in MBC patients. A total of 3,218 MBC patients from fourteen eligible studies were evaluated. The pooled hazard ratios (HR) for EMT-TFs suggested that high EMT-TF expression was significantly associated with poor prognosis in MBC patients (HRs = 1.72; 95% confidence intervals (CIs) = 1.53–1.93; P = 0.001). In addition, the overexpression of SLUG was the most impactful on the risk of MBC compared with TWIST1 and SNAIL1, which sponsored fixed models. Strikingly, the increased risk of MBC was less associated with ZEB1 expression. However, the EMT-TF expression levels significantly increased the risk of MBC in the Asian population (HR = 2.11, 95% CI = 1.70–2.62) without any publication bias (t = 1.70, P = 0.11). These findings suggest that the overexpression of potentially TWIST1, SNAIL1 and especially SLUG play a key role in the aggregation of MBC treatment as well as in the improvement of follow-up plans in Asian MBC patients.

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“…Among the included articles, the protein expression level was detected using IHC in 22 studies [6,8,10,12,13,[15][16][17][18][19][20]25,[29][30][31][32][33][34][35][36][37][38], the mRNA transcriptional level was probed by RT-qPCR in 5 studies [7,9,14,22,39], and both methods were used in 1 study [10]. In terms of the NOS scale, 9 articles scored 9, 4 articles scored 8, 7 articles scored 7 and 3 articles scored 6 in the protein group; 2 articles scored 9, 2 articles scored 8 and the rest two articles scored 7 and 6, respectively, in the mRNA group ( Table S1).…”

Section: Studies Identification and Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…Slug (Snail2) is a zinc finger protein of the Snail family, which was first found in the neural crest and developed into mesoderm of early chick embryos [5]. Its expression has been investigated in different types of cancers, such as oesophageal carcinoma [6,7], gastric carcinoma [8,9], colorectal carcinoma [10,11], hepatocellular carcinoma [12], pulmonary carcinoma [13][14][15][16], head and neck squamous cell carcinoma (HNSCC) [13,14], breast cancer [15][16][17], prostate cancer [18], bladder cancer [19,20], gynaecological cancer [21,22] and malignant mesothelioma [23]. Some studies have demonstrated slug expression was related to tumour aggressiveness, as was confirmed by the association with tumour grade, distant metastasis and shorter survival of patients, no matter whether there was loss of E-cadherin expression [24].…”

Section: Introductionmentioning

confidence: 99%

The prognostic implication of slug in all tumour patients – a systematic meta‐analysis

Huang

Zhang

et al. 2016

Eur J Clin Investigation

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Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor

Abstract: The evaluation of the co-expression of ALDH1 and transcription factors in primary lesions may be useful in prognosis of node-positive breast cancers.

Cited by 21 publications

References 25 publications

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

Prognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis

The prognostic implication of slug in all tumour patients – a systematic meta‐analysis

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