The prognostic implication of slug in all tumour patients – a systematic meta‐analysis

Huang, Cheng; Zhang, Ping; Zhang, Depu; Weng, Xisheng

doi:10.1111/eci.12608

Cited by 8 publications

(7 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulating evidence has demonstrated that these EMT‐TFs are associated with invasion and metastasis in HNSCC . In our previous studies, we found that ZEB2 and SNAI2 enhanced the invasive and metastatic capability of HNSCC cells and their expression was correlated with a poor prognosis, which was also confirmed by several other studies . However, a comprehensive pooled analysis investigating the prognostic value of EMT‐TFs in HNSCC was still lacking.…”

Section: Discussionsupporting

confidence: 74%

Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis

et al. 2020

View full text Add to dashboard Cite

Epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT-inducing transcription factors (EMT-TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT-TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT-TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta-analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT-TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67-2.23) of HNSCC. Subgroup analysis for individual EMT-TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29-2.02), SNAI1 (HR = 2.17, 95% CI = 1.63-2.88), SNAI2 (HR = 1.90, 95% CI = 1.38-2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61-4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT-TFs indicates a poor prognosis for HNSCC patients. K E Y W O R D S biomarkers, EMT-TFs, HNSCC, meta-analysis, prognosis

show abstract

Section: Discussionsupporting

confidence: 74%

Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These proteins are responsible for downregulating E-cadherin and activating traits leading to the upregulation of mesenchymal markers, additionally influencing apoptosis, angiogenesis, and cell migration (86)(87)(88). The overexpression of each of these transcription factors has been confirmed to have a negative prognostic significance in most common epithelial cancers (88)(89)(90). In our study, we observed an elevated SNAIL, SLUG, and Twist1 immunoreactivity in NSCLC compared to NMLT samples, which is in line with previous literature reports (91)(92)(93).…”

Section: Discussionsupporting

confidence: 92%

SATB1 protein is associated with the epithelial‑mesenchymal transition process in non‑small cell lung cancers

et al. 2021

View full text Add to dashboard Cite

Lung cancer is one of the most frequently diagnosed neoplasms and the leading cause of cancer-related mortality worldwide. Its predominant subtype is non-small cell lung cancer (NSCLC), which accounts for over 80% of the cases. Surprisingly, the majority of lung cancer-related deaths are caused not by a primary tumour itself, but by its metastasis to distant organs. Therefore, it becomes especially important to identify the factors involved in lung cancer metastatic spread. Special AT-rich binding protein 1 (SATB1) is a nuclear matrix protein that mediates chromatin looping and plays the role of global transcriptional regulator. During the past decade, it has received much attention as a factor promoting tumour invasion. In breast, colorectal and prostate cancers, SATB1 has been shown to influence the epithelial-mesenchymal transition (EMT) process, which is thought to be crucial for cancer metastasis. The aim of this study was to analyse the possible correlations between the expression of SATB1 and major EMT-associated proteins in NSCLC clinical samples. Additionally, the impact of EMT induction in NSCLC cell lines on SATB1 mRNA expression was also investigated. Immunohistochemistry was used to assess the expression of SATB1, SNAIL, SLUG, Twist1, E-cadherin, and N-cadherin in 242 lung cancer clinical samples. EMT was induced by TGF-β1 treatment in the A549 and NCI-H1703 lung cancer cell lines. Changes in gene expression profiles were analyzed using real-time PCR and Droplet Digital PCR. SATB1 expression was positively correlated with the expression of SNAIL (R=0.129; P=0.045), SLUG (R=0.449; P<0.0001), and Twist1 (R=0.264; P<0.0001). Moreover, SATB1 expression significantly increased after in vitro EMT induction in A549 and NCI-H1703 cell lines. The results obtained may point to the role of SATB1 as one of the regulators of EMT in NSCLC.

show abstract

“…Another major limitation of this study is that the results have not yet been validated with an independent data set [7] and should therefore be considered preliminary. It should finally be noted that in contrast to univariate [56] or genomic analyses [57], Slug IHC status was not prognostic in this multivariable analysis (p = 0.13; Figure 5; Table S3).…”

Section: Discussionmentioning

confidence: 62%

The Epithelial-Mesenchymal Transcription Factor Slug Predicts Survival Benefit of Up-Front Surgery in Head and Neck Cancer

Riechelmann

Steinbichler

Sprung

et al. 2021

Cancers

View full text Add to dashboard Cite

EMT promotes radio- and chemotherapy resistance in HNSCC in vitro. As EMT has been correlated to the transcription factor Slug in tumor specimens from HNSCC patients, we assessed whether Slug overexpression predicts radio- and chemotherapy resistance and favors upfront surgery in HNSCC patients. Slug expression was determined by IHC scoring in tumor specimens from patients with incident HNSCC. Patients were treated with either definitive radiotherapy or chemoradiotherapy (primary RT/CRT) or upfront surgery with or without postoperative RT or CRT (upfront surgery/PORT). Treatment failure rates and overall survival (OS) were compared between RT/CRT and upfront surgery/PORT in Slug-positive and Slug-negative patients. Slug IHC was positive in 91/354 HNSCC patients. Primary RT/CRT showed inferior response rates (univariate odds ratio (OR) for treatment failure, 3.6; 95% CI, 1.7 to 7.9; p = 0.001) and inferior 5-year OS (univariate, p < 0.001) in Slug-positive patients. The independent predictive value of Slug expression status was confirmed in a multivariable Cox model (p = 0.017). Slug-positive patients had a 3.3 times better chance of survival when treated with upfront surgery/PORT versus primary RT/CRT. For HNSCC patients, Slug IHC represents a novel and feasible predictive biomarker to support upfront surgery.

show abstract

The prognostic implication of slug in all tumour patients – a systematic meta‐analysis

Abstract: The protein expression rather than mRNA transcription of Slug should be considered as a potent biomarker for poor prognosis of tumours, particularly head and neck cancer as well as lung and urinary carcinomas.

Cited by 8 publications

References 51 publications

Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis

Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis

SATB1 protein is associated with the epithelial‑mesenchymal transition process in non‑small cell lung cancers

The Epithelial-Mesenchymal Transcription Factor Slug Predicts Survival Benefit of Up-Front Surgery in Head and Neck Cancer

Contact Info

Product

Resources

About