Evaluation of a novel very high sun-protection-factor moisturizer in adults with rosacea-prone sensitive skin

Abstract

Background/objectiveRosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners.Subjects and methodsThis was an open-label, single-center study. On day 1, before treatment, subjects answered a questionnaire on their skin conditions and sunscreen habits, and both subjects and dermatologist evaluated skin status. Subjects applied the product once daily in the morning to the face for 21 days, and after approximately 3–5 minutes they assessed tolerability and short-term cosmetic acceptability in a questionnaire and daily diary. On day 22, the dermatologist and subjects evaluated skin status for long-term tolerance and cosmetic acceptability.ResultsThe study enrolled 44 individuals (mean age 58.8 years, 91% female). At baseline, most subjects (39 of 44) showed erythema, and ~30% showed dryness and scaling. Dermatologists noted four cases of pustules and one case of papules. After 21 days’ treatment with the product, the dermatologist reported significantly less erythema, dryness and scaling, three cases of pustules and two cases of papules. At baseline, ~75% of subjects noted a feeling of dryness, >50% reported tension, and nearly 25% reported tickling. After using the product for 21 days, subjects reported significantly less tension, dryness, and tickling. Some subjects noted itching and burning before and after using the product. One subject noted papules during treatment. Most subjects said that the product was pleasant, did not irritate the skin or cause stinging/burning, was easy to apply, quickly absorbed, and nongreasy, improved skin moisturization, helped prevent sun-provoked facial redness, did not worsen rosacea, and was easily incorporated into their skincare regimen. Half would switch to the product, and 80% of subjects would buy and recommend the product.ConclusionThe product was well tolerated in rosacea-prone subjects, producing objective and subjective improvements in skin status and symptoms.

Clinical and in vitro evaluation of new anti‐redness cosmetic products in subjects with winter xerosis and sensitive skin

“…There is limited published data describing the effect of topical serums on sensitive skin. Clearly sunscreen use will reduce skin erythema but many plant extracts and oils/acids as well as beta glucans, sodium hyaluronate, glycerine, 4‐t‐butylcyclohexanol, tranexamic acid, oxyresveratrol, glutathione disulphide, licochalcone A and niacinamide are also known to reduce skin redness .…”

“…Another potential limitation to the study is the lack of a vehicle‐control or comparative product and only changes from baseline levels were assessed. It is noted, however, many studies examining improving facial redness use a similar clinical approach .…”

“…While reducing the negative effects of UV irradiation is key in alleviating sensitive skin symptoms, maintaining adequate moisturization is also important . Formulations that contain lamellar lipid bilayers, mimicking those found within the SC, are known to be more effective clinically than non‐lamellar lipid formulations in treating dry skin and uremic pruritus in addition to improving barrier function and erythema in subjects with sensitive skin and atopic eczema .…”

A predictive model for differential diagnosis between rosacea and sensitive skin: a cross-sectional study

“…In anatomy, these areas receive blood supply from the arteria supratrochlearis, arteria angularis, and arteria infraorbitali. [ 5 ] It can be hypothesized that the abnormal dilation of these arteries may be the cause of this pattern. The red area distribution of rosacea was mostly peace sign-shaped (54.7%), which also appeared in 14.9% SS patients.…”

“…It is speculated that this pattern may be caused by abnormal vessel dilation of the anastomotic branches of the zygomatic-facial artery and facial artery. [ 5 ] The wing shape pattern appeared in 19.9% of rosacea patents, while no SS patient had this pattern. An earlobe pattern was another common pattern in rosacea patients (50.7%), with only 12.2% of SS patients presenting with this pattern, probably because external stimuli rarely affected the earlobe.…”