Evaluation of a novel nanocrystalline hydroxyapatite paste and a solid hydroxyapatite ceramic for the treatment of critical size bone defects (CSD) in rabbits

Huber, F.-X.; Berger, Irina; McArthur, Nicholas; Huber, Colette; Kock, Hans-Peter; Hillmeier, Jürgen; Meeder, P. J.

doi:10.1007/s10856-007-3039-0

Cited by 61 publications

(38 citation statements)

References 42 publications

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“…For a number of clinical applications, Ostim® might be combined with other types of calcium orthophosphate bioceramics, e.g., with a HA bioceramic core (Cerabone®) [610,624] or with biphasic (β-TCP + HA) granules (BoneSaves®) [625]. Application of such combinations of a nanocrystalline Ostim® with the microcrystalline calcium orthophosphate bioceramics appeared to be an effective method for treatment of both tibia head compression fractures [610] and metaphyseal osseous volume defects in the metaphyseal spongiosa [624]. Besides, such combinations might be used for acetabular bone impaction grafting procedures [625].…”

Section: Bone Repairmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Bone Repairmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Grigoryan et al described the rapid bone ingrowth at a low complication rate following the treatment of jaw defects with Ostim ® in dogs in 2000 [61]. Our own animal experiments dealing with the filling of critical size defects with Ostim in New Zealand white rabbits also resulted in swift and uniform bone ingrowth[62]. The results were further enhanced by the additional use of a sintered hydroxyapatite ceramic[62].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a novel nanocrystalline hydroxyapatite paste Ostim® in comparison to Alpha-BSM® - more bone ingrowth inside the implanted material with Ostim® compared to Alpha BSM®

Huber¹,

McArthur

Heimann³

et al. 2009

BMC Musculoskelet Disord

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BackgroundThe purpose of this study was to evaluate the performance a newly developed nanocrystalline hydroxyapatite, OSTIM® following functional implantation in femoral sites in thirty-eight sheep for 1, 2 or 3 months. Ostim® 35 was compared to an established calcium phosphate, Alpha BSM®.MethodsBiomechanical testing, μ-CT analysis, histological and histomorphological analyses were conducted to compare the treatments including evaluation of bone regeneration level, material degradation, implant biomechanical characteristics.ResultsThe micro-computed tomography (μCT) analysis and macroscopic observations showed that Ostim® seemed to diffuse easily particularly when the defects were created in a cancellous bone area. Alpha BSM® remained in the defect.The performance of Ostim was good in terms of mechanical properties that were similar to Alpha BSM® and the histological analysis showed that the bone regeneration was better with Ostim® than with Alpha BSM®. The histomorphometric analysis confirmed the qualitative analysis and showed more bone ingrowth inside the implanted material with Ostim® when compared to Alpha BSM ® at all time points.ConclusionsThe successful bone healing with osseous consolidation verifies the importance of the nanocrystalline hydroxyapatite in the treatment of metaphyseal osseous volume defects in the metaphyseal spongiosa.

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“…HA ceramics like Endobon Ò and Pro Osteon 500 Ò are fairly inert [39][40][41][42][43][44], whereas the HA cement Ostim Ò was shown to be biodegradable by osteoclastic activity [45][46][47][48][49][50]. After 1 year, 70% of the implanted material was resorbed in tibia bone of minipigs [50], but a recently published study found only minimal resorption of Ostim Ò after an implantation period of 12 weeks in rabbits femora [51].…”

Section: Biological Propertiesmentioning

confidence: 99%

Bone substitutes in the Netherlands – A systematic literature review

Stok¹,

Lieshout²,

El-Massoudi³

et al. 2011

Acta Biomaterialia

210

130

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Autologous bone grafting is currently considered as the gold standard to restore bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) bone substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of bone substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

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Evaluation of a novel nanocrystalline hydroxyapatite paste and a solid hydroxyapatite ceramic for the treatment of critical size bone defects (CSD) in rabbits

Cited by 61 publications

References 42 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Evaluation of a novel nanocrystalline hydroxyapatite paste Ostim® in comparison to Alpha-BSM® - more bone ingrowth inside the implanted material with Ostim® compared to Alpha BSM®

Bone substitutes in the Netherlands – A systematic literature review

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