Evaluation of a modified halo flowing atmospheric pressure afterglow ion source for the analysis of directly injected volatile organic compounds

Fandiño, Jonatan; Orejas, Jaime; Chauvet, Laura; Blanco, David; Guillot, Philippe; Pisonero, Jorge; Bordel, Nerea

doi:10.1039/d0ja00140f

Cited by 5 publications

(6 citation statements)

References 39 publications

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“…The FAPA source applies the afterglow from a DC helium glow discharge to thermally desorb and ionize samples. In addition, FAPA has several different geometries, including the original pin‐to‐plate configuration (Andrade et al, 2008a), the pin‐to‐capillary configuration (Shelley et al, 2011), the concentric‐electrode configuration (Pfeuffer et al, 2013), and the modified concentric‐electrode configuration (Fandino et al, 2020). The schematic diagram of the original pin‐to‐plate FAPA is shown in Figure 3 (Ⅰ‐a), the anode is a metal plate with a hole, which allows discharge species to flow into the afterglow region.…”

Section: Plasma‐based Amsmentioning

confidence: 99%

Plasma‐based ambient mass spectrometry: Recent progress and applications

Yue

Zhao

et al. 2021

Mass Spectrometry Reviews

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Ambient mass spectrometry (AMS) has grown as a group of advanced analytical techniques that allow for the direct sampling and ionization of the analytes in different statuses from their native environment without or with minimum sample pretreatments. As a significant category of AMS, plasma-based AMS has gained a -• , CO 3 -• , NO 2 -• , and the most abundant species is O 2 -• (Cody & Dane, 2013). A review by Gross (Gross, 2014) explained the ionization mechanism in greater detail, and the typical ions generated in the DART source are shown in Table 2. Another

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Section: Plasma‐based Amsmentioning

confidence: 99%

Plasma‐based ambient mass spectrometry: Recent progress and applications

Yue

Zhao

et al. 2021

Mass Spectrometry Reviews

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“…Alves et al reported an ion source for liquid samplingatmospheric pressure glow discharge (LS-APGD) to produce ion intensities equal to or higher (>15%) than that of electrospray ionisation for marine-relevant salt-containing organic samples [20]. Fandino et al evaluated a modified halo-shaped flowing atmospheric pressure afterglow (h-FAPA) source for direct analysis of benzene in volatile organic compounds with low matrix effects [21] and Zhang et al designed a reactive-FAPA ionisation source for rapid isomer differentiation by real-time derivatisation of analytes [22]; moreover, Guć et al analysed perfume components in cosmetics using FAPA-MS by directly determining the fragrance components: patchoulol, farnesol, safrole, geraniol, eucalyptol, and R-carvone [23]. These applications implied that the introduction of afterglow into APGD could not only extend the direct analysis of various types of samples [24], but also provide some possibilities for the identification of short-lived intermediates, even in complicated systems.…”

Section: Introductionmentioning

confidence: 99%

Studies of Dopamine Oxidation Process by Atmospheric Pressure Glow Discharge Mass Spectrometry

Dai

Zhu

et al. 2023

Molecules

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An atmospheric pressure glow discharge ionisation source was constructed and utilized to study the dopamine (DA) oxidation process coupling with mass spectrometry. During the DA oxidation process catalysed by polyphenol oxidase (PPO), six cationic intermediates were directly detected by the atmospheric pressure glow discharge mass spectrometry (APGD-MS). Combined with tandem mass spectrometry, the structures of the dopamine o-semiquinone radical (DASQ) and leukodopaminochrome radical (LDAC●) intermediates and structures of the isomers of dopaminochrome (DAC) and 5,6-dihydroxyindole (DHI) were further characterised with the introduction of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) and deuterium oxide (D2O) to APGD-MS. Meanwhile, UV–Vis studies confirmed the important role of PPO in catalyzing the DA oxidation reaction. Based on APGD-MS studies, a possible mechanism could be proposed for DA oxidation catalysed by PPO. Furthermore, APGD-MS could provide possibilities for the effective detection and characterisation of short-lived intermediates, even in complicated systems.

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“…In 2020, a halo-flowing atmospheric-pressure afterglow ion source (h-FAPA) was used for the determination of VOCs [ 23 ]. This plasma-based ionization source was combined with an atmospheric pressure ionization time-of-flight mass spectrometer (API-TOFMS).…”

Section: Introductionmentioning

confidence: 99%

“…Oxygen and other oxidized species (e.g., pyrylium) were also observed in the mass spectra due to a special interface between the source and API-TOFMS. Since this is a brand new source type, tested only at a rather stable compound, it is currently hard to predict and evaluate the actual fragmentation of different groups of VOCs [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Volatile Organic Compound Fragmentation in the Afterglow of Pulsed Glow Discharge in Ambient Air

et al. 2022

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Glow discharge (GD) source gained an increased level of attention in relation to the analysis of volatile organic compounds (VOCs) since past work showed that this soft ionization method allowed direct analysis of VOCs with minimal fragmentation, however, the issue of fragmentation was not previously studied in detail. The aim of the present work was to investigate the effect of discharge conditions on VOC fragmentation in the system consisting of the cell with pulsed glow discharge and a time-of-flight mass spectrometer. Ionization of VOCs of different classes (hydrocarbons, alcohols, esters, and carboxylic acids) was investigated. A copper cathode with flat geometry was used. VOCs were ionized in the afterglow of short pulse glow discharge in the air. The use of discharge afterglow significantly reduces or eliminates the effects of ionization mechanisms other than Penning process, in particular, electron ionization. This significantly reduced VOC fragmentation and provided rather low limits of detection. Specific cluster formation was observed for alcohols and esters, which may facilitate their identification.

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Evaluation of a modified halo flowing atmospheric pressure afterglow ion source for the analysis of directly injected volatile organic compounds

Abstract: A modified Flowing Atmospheric Pressure Afterglow source with concentric-tube electrodes (modified-hFAPA) is coupled to an Atmospheric Pressure Interface Time of Flight Mass Spectrometer (API-TOFMS) for the analysis of gas samples....

Cited by 5 publications

References 39 publications

Plasma‐based ambient mass spectrometry: Recent progress and applications

Plasma‐based ambient mass spectrometry: Recent progress and applications

Studies of Dopamine Oxidation Process by Atmospheric Pressure Glow Discharge Mass Spectrometry

Volatile Organic Compound Fragmentation in the Afterglow of Pulsed Glow Discharge in Ambient Air

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