Evaluation of a Gelatin-Modified Poly(<i>ε</i>-Caprolactone) Film as a Scaffold for Lung Disease

Kosmala, A.; Fitzgerald, Michelle; Moore, Eric; Stam, Frank

doi:10.1080/00032719.2016.1163363

Cited by 17 publications

(14 citation statements)

References 49 publications

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“…Meanwhile, the studies about the organic materials are more extensive and have shown fruitful results; researchers have prepared carriers from both natural polymers and synthetic polymers . Comparing with the natural polymers, the synthetic polymers are more systemically studied, and the most representative is the macromolecule epoxy series . To improve the property of immobilized PGA, some reports have designed a large number of novel composite carriers based on advantages from both the organic materials and the inorganic materials …”

Section: Introductionmentioning

confidence: 99%

“…11,12 Comparing with the natural polymers, the synthetic polymers are more systemically studied, and the most representative is the macromolecule epoxy series. 13,14 To improve the property of immobilized PGA, some reports have designed a large number of novel composite carriers based on advantages from both the organic materials and the inorganic materials. 15,16 Although there are many studies on PGA immobilization, the compatibility of PGA carrier in terms of high load, fast response rate, and high recovery is not well resolved.…”

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confidence: 99%

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Design and synthesis study of the thermo‐sensitive copolymer carrier of penicillin G acylase

Chen

Liu

et al. 2018

Polymers for Advanced Techs

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Reversible‐addition‐fragmentation chain transfer polymerization method was adopted here in this study to prepare a series of thermo‐sensitive tri‐block copolymer carrier, poly(N,N‐diethylacrylamide‐b‐β‐hydroxyethyl methacrylate‐b‐glycidyl methacrylate), PDEA‐b‐PHEMA‐b‐PGMA (named as DHG). Their structures and temperature sensitivity performances were further characterized by the nuclear magnetic resonance, the gel permeation chromatography, and the fluorescence spectroscopy, respectively. It has been identified that the synthesis reaction of tri‐block copolymer was living polymerization. The thermo‐sensitivity study suggested that 2 monomers, β‐hydroxyethyl methacrylate and glycidyl methacrylate, played key roles on the lower critical solution temperature performance. Finally, above block copolymer was conscripted to immobilize penicillin G acylase; relationships among the number‐average molar weight ()trueM¯n of the 2 monomer, β‐hydroxyethyl methacrylate and glycidyl methacrylate, loading (L), and activity recover rate (Ar) of immobilized PGA were investigated. And the results showed that L and Ar arrived at 19 502 U and 92%, respectively.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Design and synthesis study of the thermo‐sensitive copolymer carrier of penicillin G acylase

Chen

Liu

et al. 2018

Polymers for Advanced Techs

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“…Adherence of NCI-H292 cells; tuning mechanical properties of materials [177,178,248] bFGF and AA2P based PGA/PLA Improving cells adhesion and stimulates cells proliferation and differentiation [249] Kidney (Section 6.2) Mg(OH) 2 and acellular ECM PLGA Neutralization of the effects induced by degradation of PLGA products, suppression of inflammatory reactions [186] l-DOPA and collagen IV PCL Improving cells adhesion and proliferation [250] Liver (Section 6.3) ECM-molecules PLA Microenvironment manipulation; changes of gene expression, protein contents, and cell adherence [251] PCL [252] HGF based Gelatin Controlled release for enhancement of the in vivo therapeutic effects RGD and YIGSR based PCL and PLA Improved hepatocyte adhesion [196] Cardiac muscles (Section 7.1) bFGF based PLGA Neovascular formation [253] Laminin based PU Improving cells adhesion [254] Skeletal muscles (Section 7.2)…”

Section: Gelatin Based Pcl Pgamentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

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In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

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“…Kosmala et al performed some modifications on PCL by immobilizing gelatin on the PCL surface using the amine groups. The modification of PCL increased both the strength and the biocompatibility of the material but also resulted in a loss of flexibility [ 272 ]. PCL showed no cytotoxic effects, and the cells spread properly.…”

Section: Pulmonary System and Diseasesmentioning

confidence: 99%

“…PCL showed no cytotoxic effects, and the cells spread properly. Furthermore, there was increased cellular proliferation on the modified PCL relative to control [ 272 ]. In this study, PCL/gelatin modification did not inhibit the spread of the human epithelial cell line NCI-H292 cells.…”

Section: Pulmonary System and Diseasesmentioning

confidence: 99%

Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

Fakoya

Otohinoyi

Yusuf

2018

Stem Cells International

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The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncomplicated, the tissues that make up this system are undoubtedly complex. Hence, damage to this system is undesirable as its capacity to self-regenerate is quite limited. The surge in the incidence and prevalence of cardiopulmonary diseases has reached a critical state for a top-notch response as it currently tops the mortality table. Several therapies currently being utilized can only sustain chronically ailing patients for a short period while they are awaiting a possible transplant, which is also not devoid of complications. Regenerative therapeutic techniques now appear to be a potential approach to solve this conundrum posed by these poorly self-regenerating tissues. Stem cell therapy alone appears not to be sufficient to provide the desired tissue regeneration and hence the drive for biomaterials that can support its transplantation and translation, providing not only physical support to seeded cells but also chemical and physiological cues to the cells to facilitate tissue regeneration. The cardiac and pulmonary systems, although literarily seen as just being functionally and spatially cooperative, as shown by their diverse and dissimilar adult cellular and tissue composition has been proven to share some common embryological codevelopment. However, necessitating their consideration for separate review is the immense adult architectural difference in these systems. This review also looks at details on new biological and synthetic biomaterials, tissue engineering, nanotechnology, and organ decellularization for cardiopulmonary regenerative therapies.

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Evaluation of a Gelatin-Modified Poly(ε-Caprolactone) Film as a Scaffold for Lung Disease

Cited by 17 publications

References 49 publications

Design and synthesis study of the thermo‐sensitive copolymer carrier of penicillin G acylase

Design and synthesis study of the thermo‐sensitive copolymer carrier of penicillin G acylase

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

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