Evaluation of a condensation nucleation light scattering detector for the analysis of synthetic polymer by supercritical fluid chromatography

Supercritical Fluid Chromatography

“…CAD was able to detect 10 -fold diluted solutions of uniform oligomers compared to ELSD. Recently, the same group reported a condensation nucleation light -scattering detector ( CNLSD ) used for SFC (Takahashi et al, 2009 ). In comparison with ELSD, the CNLSD was able to detect a 10 -fold less concentrated solution of uniform oligomers.…”

Supercritical Fluid Chromatography

“…A condensation nucleation light scattering detector (CNLSD) was adapted for use as a detector for SFC (22). The performance of the CNLSD was evaluated and compared to ELSD using a welldefined equimass mixture of poly(ethylene glycol) 1000.…”

Simultaneous determination of polysorbate 20 and unbound polyethylene-glycol in protein solutions using new core–shell reversed phase column and condensation nucleation light scattering detection

“…The limits of detection for CNLSD were greatly improved compared to ELSD. Takahashi et al applied CNLSD detection for supercritical fluid chromatography to detect synthetic polymers [22].…”