Evaluation of a Bioabsorbable Self-Expandable Vein Stent-Base Made of Poly(l-lactide) In Vitro and In Vivo

Løvdal, Alexandra Liv Vest; Calve, Sarah; Yang, Shuo; Alstine, William Van; Binkert, Christoph A.; Klausen, Kasper

doi:10.1007/s00270-016-1491-2

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Numerous studies in recent years have investigated DES/nanoparticle‐eluting stents coated with biodegradable PLGA and other nanofibres, aiming at sustained drug delivery and a substantially reduced thrombosis . A study also evaluated the performance of a self‐expandable bioabsorbable poly‐ l ‐lactide (PLLA) stent that showed adequate radial force to avoid migration but eventually resulted in a stent failure because the explant demonstrated multiple circumferential fractures . Masuda et al investigated imatinib mesylate, a PGDF receptor tyrosine kinase inhibitor encapsulated bioabsorbable PLGA polymeric nanoparticle‐eluting stent, in a pig coronary artery stent model.…”

Section: Nanoparticle‐des/ges To Negate Isr and Boost Re‐endothelialimentioning

confidence: 99%

“…27 A study also evaluated the performance of a selfexpandable bioabsorbable poly-L-lactide (PLLA) stent that showed adequate radial force to avoid migration but eventually resulted in a stent failure because the explant demonstrated multiple circumferential fractures. 28 Masuda et al 29 investigated imatinib mesylate, a PGDF receptor tyrosine kinase inhibitor encapsulated bioabsorbable PLGA polymeric nanoparticle-eluting stent, in a pig coronary artery stent model. The angiographic, histopathological and intravascular ultrasound imaging results of their study showed inhibition of vascular smooth muscle cell (VSMC) proliferation with no adverse effects on endothelial cells in vitro, thereby attenuating in-stent neointimal formation by approximately 50%.…”

Section: Nanoparticle-des/ges To Negate Isr and Boost Re-endotheliamentioning

confidence: 99%

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Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

Krishnagopal

Reddy

Sen

2017

The Journal of Gene Medicine

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This review concisely recapitulates the different existing modes of stent-mediated gene/drug delivery, their considerable advancement in clinical trials and a rationale for other merging new technologies such as nanotechnology and microRNA-based therapeutics, in addition to addressing the limitations in each of these perpetual stent platforms. Over the past decade, stent-mediated gene/drug delivery has materialized as a hopeful alternative for cardiovascular disease and cancer in contrast to routine conventional treatment modalities. Regardless of the phenomenal recent developments achieved by coronary interventions and cancer therapies that employ gene and drug-eluting stents, practical hurdles still remain a challenge. The present review highlights the limitations that each of the existing stent-based gene/drug delivery system encompasses and therefore provides a vision for the future with respect to discovering an ideal stent therapeutic platform that would circumvent all the practical hurdles witnessed with the existing technology. Further study of the improvisation of next-generation drug-eluting stents has helped to overcome the issue of restenosis to some extent. However, current stent formulations fall short of the anticipated clinically meaningful outcomes and there is an explicit need for more randomized trials aiming to further evaluate stent platforms in favour of enhanced safety and clinical value. Gene-eluting stents may hold promise in contributing new ideas for stent-based prevention of in-stent restenosis through genetic interventions by capitalizing on a wide variety of molecular targets. Therefore, the central consideration directs us toward finding an ideal stent therapeutic platform that would tackle all of the gaps in the existing technology.

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Section: Nanoparticle‐des/ges To Negate Isr and Boost Re‐endothelialimentioning

confidence: 99%

Section: Nanoparticle-des/ges To Negate Isr and Boost Re-endotheliamentioning

confidence: 99%

Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

Krishnagopal

Reddy

Sen

2017

The Journal of Gene Medicine

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An Overview of the Design, Development and Applications of Biodegradable Stents

Nakka

Nagarajan

Sundaravadivel

et al. 2020

DDL

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Background & Objectives: Stents have been effectively used in the treatment of vascular diseases and further explorations are going on in treating various strictures including tracheal, intestinal, nasal, urethra and esophageal. Stents serve as a support to walls of the lumen to prevent restenosis. Metal stents prevent in-stent restenosis but the corrosion of the metallic framework causes further complications. To overcome the shortcomings of metallic stents, metallic Drug-Eluting Stents (DES) have been designed where the drugs are chosen as an anti-restenosis agent in such a way that it prevents thrombosis, neointimal proliferation and possess immunosuppressive properties. Biodegradable stents are becoming ideal, provided they effectively spot the target stricture and have long-term stability to support the walls of the body conduit which in turn aids in eliminating the need for a second surgery. Polymeric materials can be used to enhance the mechanical strength and prolong the degradation time of biodegradable DES, thereby making it an ideal choice for stenting. Discussion: This review focus on the progress made in the design, manufacture, characterization studies and applications of stents over the past decade. Conclusion: We concluded that the use of stents is now an emerging technique for the treatment of GI strictures caused due to colorectal cancer, esophageal cancer, cholangiocarcinoma, Crohn’s disease etc. Though BDS have several advantages, advanced techniques are needed for fabrication and suitable modification in the design of the scaffold to enhance its clinical efficacy and to thereby develop an ideal endoprosthetic device.

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Mechanical characteristics of venous stents to overcome challenges of venous outflow obstruction

Lim

Black

2022

Int Angiol

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Evaluation of a Bioabsorbable Self-Expandable Vein Stent-Base Made of Poly(l-lactide) In Vitro and In Vivo

Abstract: PurposeThis study was designed to evaluate performance and tissue response to a self expandable bioabsorbable vein stent base cut from a tube with enhanced stiffness and strength in vitro and in vivo.

Cited by 3 publications

References 29 publications

Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

An Overview of the Design, Development and Applications of Biodegradable Stents

Mechanical characteristics of venous stents to overcome challenges of venous outflow obstruction

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