Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

Chemotherapy is one of the important means of tumor therapy. However, most of the anti-tumor drugs that currently used in clinic are hydrophobic non-specific drugs, which seriously affect the efficacy of drugs. With the development of nanotechnology, drug efficacy can be improved by selecting appropriate biodegradable nanocarriers for achieving the controlled release, targeting and higher bioavailability of drugs. This paper reviewed the research progress of anti-tumor drug nanoparticle carriers, which mainly summarized the materials used for anti-tumor drug nanoparticle carriers and their effects in anti-tumor drugs, as well as the targeted drug delivery methods of anti-tumor drugs based on nanocarriers.

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“…Gene therapy played an important role in cancer treatment ( 31 ). The carrier of gene therapy was the key to the success of gene therapy ( 32 ).…”

Section: Nano Carriers For Anti-tumor Drugmentioning

confidence: 99%

Advanced Nano-Carriers for Anti-Tumor Drug Loading

et al. 2021

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“…The accumulation of gene mutations is closely related to the occurrence of cancer . Hence, gene therapy plays a significant role in cancer therapy and has the potential to cure cancer …”

Section: Introductionmentioning

confidence: 99%

Tumor microenvironment as the “regulator” and “target” for gene therapy

Chen

Feng

et al. 2019

The Journal of Gene Medicine

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In this review, we focus on strategies for designing functional nano gene carriers, as well as choosing therapeutic genes targeting the tumor microenvironment. Gene mutations have a great impact on the occurrence of cancer. Thus, gene therapy plays a major role in cancer therapy and has the potential to cure cancer. Well‐designed gene therapy largely relies on effective gene carriers, which can be divided into viral carriers and non‐viral carriers. A gene carrier delivers functional genes to their intracellular target and avoids nucleic acids being degraded by nucleases in the serum. Most conventional cancer gene therapies only target cancer cells and do not appear to be sufficintly efficient to pass clinical trials. Accumulating evidence has shown that extending the therapeutic strategies to the tumor microenvironment, rather than the tumor cell itself, can allow more options for achieving robust anti‐cancer efficiency. In addition, unusual features between tumor microenvironment and normal tissues, such as a lower pH, higher glutathione and reactive oxygen species concentrations, and overexpression of some enzymes, facilitate the design of smart stimuli‐responsive gene carriers regulated by the tumor microenvironment. These carriers interact with nucleic acids and then form stable nanoparticles under physiological conditions. By regulation of the tumor microenvironment, stimuli‐responsive gene carriers are able to change their properties and achieve high gene delivery efficiency. Considering the tumor microenvironment as the “regulator” and “target” when designing gene carriers and choosing therapeutic genes shows significant benefit with respect to improving the accuracy and efficiency of cancer gene therapy.

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Hydrogel Coatings for Heart Stents

Chen

Yang²,

Guo

et al. 2019

Materials Science and Technology

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Heart stents are medical devices used to keep or expand the lumen of arteries. For more than the last three decades, percutaneous coronary intervention (PCI)‐based stent placement was applied as a primary choice in treating coronary artery diseases (CADs). Despite the success in relieving the symptoms of narrowed or weak arteries, bare metal stent placement is inevitably associated with restenosis, leading to stent failure in a relatively short timescale. To overcome this problem, bioactive‐containing polymer layer is coated on the stents, the so‐called drug‐eluting stent (DES), had been designed and successfully used to lower the restenosis rate. The in situ delivery of the active substances and/or the surface functionalities from the coatings of stents can facilitate re‐endothelialization, anti‐platelet aggregation, anti‐inflammation, and anti‐thrombosis and reduce the potential risk of PCI procedure to the surrounding tissues. Among the various coating strategies, hydrophilic polymeric hydrogel coatings show unique advantages such as capability of loading hydrophilic bioactives and/or cells, moldable softness to cell modulus, and tight fixation to arteries after placement. Consequently, hydrogel coating for heart stents are attracting more attention. This review aims at providing a timely summary and outlook for hydrogel coatings of heart stents.

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Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

Cited by 6 publications

References 87 publications

Advanced Nano-Carriers for Anti-Tumor Drug Loading

Advanced Nano-Carriers for Anti-Tumor Drug Loading

Tumor microenvironment as the “regulator” and “target” for gene therapy

Hydrogel Coatings for Heart Stents

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