Evaluation and management of acute and chronic portal vein thrombosis in patients with cirrhosis

Young, Kellie; Wong, Robert J.

doi:10.1002/cld.679

Cited by 24 publications

(31 citation statements)

References 16 publications

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“…The risk factors include: corticosteroid therapy, the obese (IBM 30 or higher), acute infections or rheumatoid disease, acute myocardial infarction, heart or lung failure, old age (more than 65 years), traumatic surgery within 30 days, high tendency to thrombosis disease, low mobility, history of VTE and active cancer patients. The score range of each of the 11 risk factors mentioned above was 1 point to 3 points, and the total score accumulation degree of all factors was divided into two grades: low risk: ≤3 points, high risk: >3 points [3].…”

Section: Methodsmentioning

confidence: 99%

Application and Reliability of Caprini Thrombus Risk Assessment Scale in Risk Assessment of Venous Thromboembolism in Acute and Severe Uygur Patients

Yue¹,

Zuo²,

Si³

et al. 2019

IJCM

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Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute and severe Uighur patients with venous thrombo embolism (VTE) that were treated in our hospital from December 2017 to December 2018 were selected as the research group. 160 cases of acute and severe uygur patients without VTE admitted to our hospital in the same period were selected as the control group. Caprini thrombus risk assessment scale and Padua thrombus risk assessment scale were used to evaluate in both groups. The general data of the two groups were compared. The results of the two groups were consistent using Caprini and Padua blood clot risk assessment scales. Clinical efficacy of two different thrombosis risk assessment scales in risk assessment of VTE. Results: Group and control group in the gender distribution, backlog of red blood cells and platelet count have no significant difference (P > 0.05), the team average age, average hospitalization days were significantly less than control group (P < 0.05), the team hemoglobin level was significantly higher than that of control group (P < 0.05), the team of white blood cells were significantly lower than control group (P < 0.05). Caprini thrombosis score was used to evaluate 156 high-risk patients and 164 low-risk patients. A total of 75 cases of high-risk patients and 245 cases of low-risk patients were assessed by Padua thrombosis score, and the results of the two assessment methods were significantly different (X 2 = 6.956, P < 0.05). Consistency (Kappa coefficient) was 0.58, indicating medium consistency. The specificity of Caprini thrombus score was significantly lower than that of Padua thrombus score (P < 0.05), the sensitivity and negative predictive value of Caprini thrombus score were significantly higher than that of Padua thrombus score (P < 0.05), and there was no significant difference in the positive predictive value between the two groups (P > 0.05). Conclusion: The sensitivity, negative predictive value and positive predictive value of Caprini thrombosis risk assessment scale in VTE risk assessment of acute and severe uygur patients are very prominent, and the clinical efficacy is better, which is worthy of application.

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Section: Methodsmentioning

confidence: 99%

Application and Reliability of Caprini Thrombus Risk Assessment Scale in Risk Assessment of Venous Thromboembolism in Acute and Severe Uygur Patients

Yue¹,

Zuo²,

Si³

et al. 2019

IJCM

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“…Определение. Тромбоз воротной вены представляет собой патологический процесс, характеризующийся окклюзией тромбом ствола воротной вены (ВВ) или ее ветвей, приводящий к нарушению или прекращению кровотока [1,2,3].…”

Section: о дним из наиболее грозных заболеваний сосудов печени являетunclassified

“…В свою очередь, тромбинемия способствует увеличению риска венозных тромбозов, в том числе ТВВ. При этом активация коагуляционного каскада не только повышает риск тромбозов, но и играет большую роль в повреждении печени, способствуя прогрессированию фиброза [1,3,12].…”

Section: о дним из наиболее грозных заболеваний сосудов печени являетunclassified

“…Классификация. ТВВ классифицируется следующим образом [ Данная классификация ТВВ широко используется специалистами лучевой диагностики, хирургами при планировании оперативного лечения и прогнозировании возможных интраоперационных осложнений [3]. Однако в настоящее время она имеет ограниченное применение в практике терапевта и гастроэнтеролога.…”

Section: Abstract: Portal Vein Thrombosis Liver Cirrhosis Direct Orunclassified

“…[18] представлены данные о том, что антикоагулянтная терапия ТВВ при ЦП в течение 6 месяцев способствовала полной реканализации ВВ у 33-45 % больных. У больных хроническим ТВВ в связи с редкостью патологии и недостаточностью доказательной базы клинические рекомендации по поводу антикоагулянтной терапии на данный момент отсутствуют [3,13].…”

Section: Abstract: Portal Vein Thrombosis Liver Cirrhosis Direct Orunclassified

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Portal vein thrombosis in the practice of the internist

Левитан¹,

Скворцов²,

Malyakin³

2020

Medical news of the North Caucasus

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TIPS for Adults Without Cirrhosis With Chronic Mesenteric Venous Thrombosis and EHPVO Refractory to Standard‐of‐Care Therapy

et al. 2021

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BaCKgRoUND aND aIMS: Extrahepatic portal vein occlusion (EHPVO) from portal vein thrombosis is a rare condition associated with substantial morbidity and mortality. The purpose of this study is to investigate the efficacy of transjugular intrahepatic portosystemic shunts (TIPS) for the treatment of chronic EHPVO, cavernomatosis, and mesenteric venous thrombosis in adults without cirrhosis who are refractory to standard-of-care therapy.appRoaCH aND ReSUltS: Thirty-nine patients with chronic EHPVO received TIPS. Laboratory parameters and follow-up were assessed at 1, 3, 6, 12, and 24 months, and every 6 months thereafter. Two hepatologists adjudicated symptom improvement attributable to mesenteric thrombosis and EHPVO before/after TIPS. Kaplan-Meier was used to assess primary and overall TIPS patency, assessing procedural success. Adverse events, radiation exposure, hospital length-ofstay and patency were recorded. Cavernoma was present in 100%, with TIPS being successful in all cases using splenic, mesenteric, and transhepatic approaches. Symptom improvement was noted in 26 of 30 (87%) at 6-month follow-up. Twelve patients (31%) experienced TIPS thrombosis. There were no significant long-term laboratory adverse events or deaths. At 36 months, freedom from primary TIPS thrombosis was 63%; following secondary interventions, overall patency was increased to 81%.CoNClUSIoNS: TIPS in chronic, noncirrhotic EHPVO with cavernomas and mesenteric venous thrombosis is technically feasible and does not adversely affect liver function. Most patients demonstrate subjective and objective benefit from TIPS. Improvement in patency rates are needed with proper timing of adjuvant anticoagulation. (Hepatology 2021;74:2735-2744.

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Evaluation and management of acute and chronic portal vein thrombosis in patients with cirrhosis

Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/10-6-reading-young.html a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/10-6-interview-young.html the interview with the author

Cited by 24 publications

References 16 publications

Application and Reliability of Caprini Thrombus Risk Assessment Scale in Risk Assessment of Venous Thromboembolism in Acute and Severe Uygur Patients

Application and Reliability of Caprini Thrombus Risk Assessment Scale in Risk Assessment of Venous Thromboembolism in Acute and Severe Uygur Patients

Portal vein thrombosis in the practice of the internist

TIPS for Adults Without Cirrhosis With Chronic Mesenteric Venous Thrombosis and EHPVO Refractory to Standard‐of‐Care Therapy

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