Evaluating chitosan/β‐tricalcium phosphate/poly(methyl methacrylate) cement composites as bone‐repairing materials

Kuo, Shyh Ming; Chang, Shwu Jen; Lin, Li-Chun; Chen, Ching Jung

doi:10.1002/app.12590

Cited by 26 publications

(2 citation statements)

References 49 publications

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“…Among common alloplastic ceramics, hydroxyapatite (HA) or tricalcium phosphate (TCP) are often incorporated in other materials as an additive in order to improve bioactivity for stimulating bone in-growth and mechanical fixation. Especially, -TCP shows that its structure and composition is similar to the inorganic part of the natural bone, and thus is often used to act as bone-grafting and dental materials [1].…”

Section: Introductionmentioning

confidence: 99%

A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects

Lee

Park

Lee³

et al. 2006

KEM

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In this study, the osteoconductive properties of novel cyanoacrylate-based filling materials for bone defect were evaluated. A new filling material was prepared by mixing Histoacryl® and acid-treated -tricalcium phosphate ( -TCP). Mixing weight ratio of acid-treated -TCP to Histoacryl® was 5:1. 12 male Spraque-Dawley rats were used in this study. The animals were divided into 4 groups. Critical-sized calvarial defects (8 mm) were created in 9 animals, and then the defects were treated with dense pellet specimen, porous cement-like specimen, and untreated defect for surgical control group. Augmentation treatments were carried out in 3 animals. Histological analysis revealed excellent ostgeoconductive properties of new filling materials. But, some of -TCP particle in the cement-like group were encapsulated by fibrous connective tissue. For the dense pellet group and augmentation treatment group, shape and stability were better maintained during the implantation time than cement like group. These results indicate that our novel -TCP/Histoacryl® composite have the potential to serve as filling materials for bone defects in the dental and plastic surgery.

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Section: Introductionmentioning

confidence: 99%

A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects

Lee

Park

Lee³

et al. 2006

KEM

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“…Among both of them, TCP ceramics with a better resoption pattern can be gradually absorbed, followed by new bone formation and without loss of bone-implant contact. Especially, β-Tricalcium phosphate (β-TCP) shows that its structure and composition is similar to the inorganic part of the natural bone, and thus is often used to act as bone-grafting and dental materials [4]. Thus, we added β-TCP particles to Histoacryl ® in order to improve bioactivity and reduce toxicity.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Cyanoacrylate-Based Filling Material for Bone Defects in Dental Applications

Park

Lee

et al. 2005

KEM

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We tried to prepare a new filling material for bone defects using β-Tricalcium phosphate (β-TCP) particles and Histoacryl®. The aim of this study was to evaluate physical and bioactive properties of cyanoacrylate-based filling materials for bone defects in the dental field. The shear bond strength values of the Histoacryl® and β-TCP/ Histoacryl® compounds stored in double-distilled water decreased with the increase of the amount of added β-TCP. The temperature change of the β-TCP/ Histoacryl® compounds during polymerization decreased compared to that of the Histoacryl®. The cytotoxicity of the filling materials decreased when the amount of added β-TCP was increased. In the evaluation of bioactivity, hydroxyapatite (HA) was precipitated on the surface and inner space of the porous filling material 4 weeks after immersion in SBF. This precipitation of HA on the surface of the filling material was also confirmed in the XRD result. These results indicate that our novel β-TCP/Histoacryl® compounds have the potential to serve as filling materials for bone defects in the dental field.

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A one‐step method for fabricating chitosan microspheres

Kuo

Niu

Chang

et al. 2004

J of Applied Polymer Sci

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A simple and in situ method, by using a high-voltage electrostatic system, for the fabrication of chitosan microspheres (in a form of isolatable microgels) by an extrusion process, exhibiting variable sizes and different membrane structures, was presented. The chitosan microspheres exhibited good sphericity and were in the range of 185.8 Ϯ 13.8 to 380.9 Ϯ 11.5 m in diameter. There were two significant factors, the pump flow rate and electrostatic field strength, that affected the chitosan microsphere size. The microsphere size decreased when the flow rate was increased from 0.1 to 0.4 mL/h. Also, the microsphere size decreased when the electrostatic field strength was increased from 5.5 to 6.5 kV/cm. However, when the electrostatic field strength was raised to 7 kV/cm and higher, the microsphere size increased. For the latter case, with other parameters fixed, chitosan microsphere size can be controlled by adjusting the electrostatic field strength and predetermined by a simple linear regression equation: Microsphere Diameter (D, in m) ϭ Ϫ(75.48) ϩ 45.67 ϫ (Electrostatic Field Strength, E, in kV/cm), at [7 Յ (Electrostatic Field Strength) Յ 10] (R 2 ϭ 0.956, P Ͻ 0.001). Following treatment with various ratios of crosslinking/gelating (Na 5 P 3 O 10 /NaOH) agents, the prepared chitosan microspheres exhibited distinct membrane structures that yielded various mechanical strengths. In the Na 5 P 3 O 10 /NaOH ratio of 19, the chitosan microspheres had a distinct two-layer structure. The selection of crosslinking/gelating ratio provided an additional degree of freedom, permitting the simultaneous regulation of mechanical properties and permeability of the microspheres, without extra manipulation, and thus, improved applicability in the biomedical field. When the chitosan microsphere extrusion process was used to encapsulate ␤-tricalcium phosphate powder for application as bony material, we found that the ultra fine ␤-tricalcium phosphate powder was trapped inside of the membrane very well. After appropriate collecting procedures, stored microspheres also retained good spherical shape.

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Evaluating chitosan/β‐tricalcium phosphate/poly(methyl methacrylate) cement composites as bone‐repairing materials

Cited by 26 publications

References 49 publications

A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects

A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects

Bioactive Cyanoacrylate-Based Filling Material for Bone Defects in Dental Applications

A one‐step method for fabricating chitosan microspheres

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