Bioactive Cyanoacrylate-Based Filling Material for Bone Defects in Dental Applications

Abstract

We tried to prepare a new filling material for bone defects using β-Tricalcium phosphate (β-TCP) particles and Histoacryl®. The aim of this study was to evaluate physical and bioactive properties of cyanoacrylate-based filling materials for bone defects in the dental field. The shear bond strength values of the Histoacryl® and β-TCP/ Histoacryl® compounds stored in double-distilled water decreased with the increase of the amount of added β-TCP. The temperature change of the β-TCP/ Histoacryl® compounds during polymerization decreased compared to that of the Histoacryl®. The cytotoxicity of the filling materials decreased when the amount of added β-TCP was increased. In the evaluation of bioactivity, hydroxyapatite (HA) was precipitated on the surface and inner space of the porous filling material 4 weeks after immersion in SBF. This precipitation of HA on the surface of the filling material was also confirmed in the XRD result. These results indicate that our novel β-TCP/Histoacryl® compounds have the potential to serve as filling materials for bone defects in the dental field.

Effect of Cyanoacrylate-Based β-TCP Adhesive on Pullout Strength of Orthodontic Mini-Screw

“…For the cementation of mini-screws into artificial bone (bone density: 0.64g/cm 2 ), test materials were prepared by mixing cyanoacrylate (Histoacryl ® , B. Braun, Germany) with acid-treated β-TCP [7]. The acidic treatment of β-TCP was performed by mixing 100 g of β-TCP (Fluka, Germany) in 50 g of 3% citric acid aqueous solution and then freeze-drying for 48 hr.…”

“…Butyl-2-cyanoacrylate adhesives have been utilized in different fields of medicine and dentistry. One of the significant advantages of cyanoacrylate adhesive is its ability to polymerize without a catalyst into a thin film at room temperature in a moist environment [4,5,6,7]. It also provides reasonable fixation properties and is emerging as an alternative to the conventional fixation system.…”

A Histological Evaluation of Novel Cyanoacrylate-Based β-TCP Composite in Rat Calvarial Defects

“…Following the acidic treatment, the -TCP particles were centrifuged and dried. Mixing weight ratio of acid-treated -TCP to Histoacryl® were 5:1, only [4]. We carried out three different in vivo tests with dense pellet specimen, porous cement like specimen, and augmentation treatment specimen of filling materials for histological evaluation.…”