Evaluating Chemical and other Agent Exosures for Reproductive and Developmental Toxicity

Mitchell, Abigail E.; Bakshi, Kulbir S.; Kimmel, Carole A.; Buck, Germaine M.; Feuston, Maureen H.; Foster, Paul M.D.; Friedman, Jan M.; Holson, Joseph F.; Hughes, Claude L.; Moore, J. A.; Schwetz, Bernard A.; Scott, William J.; Vorhees, Charles V.; Zirkin, Barry R.

doi:10.1080/15287390490460994

Cited by 16 publications

(2 citation statements)

References 157 publications

(207 reference statements)

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“…For other agents, an association with infertility is only suggested or suspected and further study is necessary to make clear conclusions. [16][17][18][19][20] Newer studies suggest that radiation deriving from such ubiquitous technology as cell phones, laptops, Wi-Fi, and microwave ovens, the most common sources of nonionizing radiations, may also contribute to male-factor infertility. 21 In addition, it is important to remember that when military service members deploy to non-Western countries or austere environments, they may have exposures to substances that are banned in the Western World.…”

Section: Occupational Exposuresmentioning

confidence: 99%

Infertility and the Military Male

Reed‐Maldonado

Madden

2019

Semin Reprod Med

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Male infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general population, but very few scientific publications focus on male factor infertility in the military population specifically. This review will discuss many of the unique considerations regarding male infertility in the military and highlight future opportunities for research. The military/federal health system has the potential to serve as a leader in both the delivery of health care for male factor infertility and in the clinical investigation into the etiologies of and treatments for male factor infertility.

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Section: Occupational Exposuresmentioning

confidence: 99%

Infertility and the Military Male

Reed‐Maldonado

Madden

2019

Semin Reprod Med

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“…Developmental toxicity refers to adverse effects of chemicals or physical agents on organismal development. Major manifestations of developmental toxicity include death of the developing organism, structural abnormality, altered growth, or functional deficiency . Unfortunately, many developmental toxicants have been detected after human exposure; thus, means for early detection of such chemicals are warranted to prevent or reduce the risk of exposure to developmental hazards.…”

Section: Introductionmentioning

confidence: 99%

Binary classification model to predict developmental toxicity of industrial chemicals in zebrafish

Ghorbanzadeh

Zhang

Andersson

2016

Journal of Chemometrics

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The identification of industrial chemicals, which may cause developmental effects, is of great importance for an early detection of hazardous chemicals. Accordingly, categorical quantitative structure-activity relationship (QSAR) models were developed, based on developmental toxicity profile data for zebrafish from the ToxCast Phase I testing, to predict the toxicity of a large set of high and low production volume chemicals (H/LPVCs). QSARs were created using linear (LDA), quadratic, and partial least squares-discriminant analysis with different chemical descriptors. The predictions of the best model (LDA) were compared with those obtained by the freely available QSAR model VEGA, created based on a dataset with a different chemical domain. The results showed that despite similar accuracy (AC) of both models, the LDA model is more specific than VEGA and shows a better agreement between sensitivity (SE) and specificity (SP). Applying a 90% confidence level on the LDA model led to even better predictions showing SE of 0.92, AC of 0.95, and geometric mean of SE and SP (G) of 0.96 for the prediction set. The LDA model predicted 608 H/LPVCs as toxicants among which 123 chemicals fall inside the AD of the VEGA model, which predicted 112 of those as toxicants. Among the 112 chemicals predicted as toxic H/LPVCs, 23 have been previously reported as developmental toxicants. The here presented LDA model could be used to identify and prioritize H/LPVCs for subsequent developmental toxicity assessment, as a screening tool of potential developmental effects of new chemicals, and to guide synthesis of safer alternative chemicals.

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