Infertility and the Military Male

Reed‐Maldonado, Amanda B.; Madden, Kristin C.

doi:10.1055/s-0039-1694027

Cited by 7 publications

(7 citation statements)

References 48 publications

(59 reference statements)

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“…Other authors studying the Mexican army population found a high prevalence of seminal HPV in healthy soldiers (49%) and concluded that a risky sexual behavior, a large number of sexual partners, and anal intercourse increase the risk of acquiring and transmitting an STI [ 19 ]. Additionally, the military status contributes to the development of several psychological, endocrinological, and immunological alterations due to stress, as reported in military communities [ 7 , 20 ]. Such conditions can increase the susceptibility to infection.…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory and Oxidative Stress States Induced by Human Papillomavirus and Chlamydia trachomatis Coinfection Affect Sperm Quality in Asymptomatic Infertile Men

et al. 2021

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Background and Objectives: To investigate the effect of infection with human papillomavirus (HPV) or Chlamydia trachomatis (CT) and HPV + CT coinfection on sperm quality, inflammation, and the state of oxidative stress (OS) in asymptomatic infertile men. Materials and Methods: Semen samples from 84 asymptomatic military infertile men were studied. The polymerase chain reaction (PCR) was used for the molecular detection of HPV and CT. Semen parameters were analyzed according to the World Health Organization guidelines. Inflammation was evaluated by an IL-1β, IL-6, and IFN-γ enzyme-linked immunosorbent assay (ELISA) and OS by the quantification of lipid peroxidation (LPO), 8-hydroxydeoxyguanosine (8-OHdG), and total antioxidant capacity (TAC). Results: A total of 81 of the 84 (96.4%) samples were positives for the pathogens, with 55/81 (68%) being positive for HPV, 11/81 (13.5%) for CT, and 15/81 (18.5%) for HPV + CT coinfection. Seminal parameters were affected in the infected groups, including pH increases above the normal range in all groups. An abnormal sperm morphology was observed in the HPV and HPV + CT groups. Higher cytokine levels were detected in the HPV group and the highest IL-1β level was found in the HPV + CT group. No cytokines were detected in the CT group. High LPO and 8-OHdG levels were found in all groups with a lower TAC. Comparisons between groups showed the highest OS state was observed in the HPV group. Conclusions: High HPV infection or coinfection (HVP + CT) in these infertile men suggest compromising male fertility by inducing a proinflammatory state and OS. Infection with CT suggests an alteration of the state of OS by promoting an alkaline pH.

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Section: Discussionmentioning

confidence: 99%

Proinflammatory and Oxidative Stress States Induced by Human Papillomavirus and Chlamydia trachomatis Coinfection Affect Sperm Quality in Asymptomatic Infertile Men

et al. 2021

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“…There are other risk factors such as risky sexual behavior, a large number of sexual partners and anal intercourse, which increase the risk of acquiring and transmitting an STI, including HPV infection in males [ 27 ]. Additionally, military status contributes to the development of psychological, endocrinological and immunological alterations due to stress [ 28 , 29 ]. Such conditions can increase the susceptibility to chronic HPV infections.…”

Section: Discussionmentioning

confidence: 99%

High-Risk HPV with Multiple Infections Promotes CYP2E1, Lipoperoxidation and Pro-Inflammatory Cytokines in Semen of Asymptomatic Infertile Men

et al. 2022

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High-risk human papillomavirus (HR-HPV) infection, followed by chronic inflammation and oxidative stress, is a major risk factor of male infertility. In this study, we explored the potential impact of high-risk (HR) HPV genotypes in single infection (SI) and multiple infections (MI) that promote CYP2E1 expression, oxidative damage and pro-inflammatory cytokines, possibly contributing to sperm damage and male infertility. Semen samples from 101 infertile military men were studied. We analyzed seminal parameters, namely, HPV genotyping, cytochrome P450 2E1 (CYP2E1), oxidative stress biomarkers (total antioxidant capacity (TAC), catalase (CAT) and superoxide dismutase (SOD)), lipid peroxidation (LPO), 8-hydroxiguanosine (8-OHdG) and pro-inflammatory cytokines (IFN-γ, IL-1β, IL-4, IL-6 and IL-8). Eighty-one men (80.2%, 81/101) were positive for HPV infection, and MI-HR-HPV was higher than SI-HR-HPV (63% vs. 37%). HPV-52 was the most frequently detected type (18.5%), followed by HPV-33 (11.1%), and the most frequent combination of genotypes detected was HPV-33,52 (11.1%), followed by HPV-18,31 (6.2%). The group with infected samples presented lower normal morphology and antioxidant levels compared to non-infected samples. In concordance, the infected group showed high levels of LPO, IFN-γ, IL-1β, IL-4 and IL-6 and downregulation of CAT and SOD enzymes. Interestingly, changes in motility B, low levels of TAC, overexpression of CYP2E1, LPO and IL-8 levels were higher in MI-HR-HPV than SI-HR-HPV, suggesting that HPV infection promotes a chronic inflammatory process and a toxic and oxidative microenvironment, which increases with MI-HPV infections.

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“…'sexy soldiers' [15,18,58,59], whereas others have argued that the costs of fighting decrease the reproductive success of fighters relative to non-combatants, e.g. 'worn-out warriors' [18,[60][61][62]. Rather than arbitrarily choosing a position on this argument, the probability of each individual reproducing in our model (i.e.…”

Section: (Ii) Distribution Of Benefits (Reproductions)mentioning

confidence: 99%

Leaders of war: modelling the evolution of conflict among heterogeneous groups

Sankey

Hunt

Croft

et al. 2022

Phil. Trans. R. Soc. B

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War, in human and animal societies, can be extremely costly but can also offer significant benefits to the victorious group. We might expect groups to go into battle when the potential benefits of victory ( V ) outweigh the costs of escalated conflict ( C ); however, V and C are unlikely to be distributed evenly in heterogeneous groups. For example, some leaders who make the decision to go to war may monopolize the benefits at little cost to themselves (‘exploitative’ leaders). By contrast, other leaders may willingly pay increased costs, above and beyond their share of V (‘heroic’ leaders). We investigated conflict initiation and conflict participation in an ecological model where single-leader–multiple-follower groups came into conflict over natural resources. We found that small group size, low migration rate and frequent interaction between groups increased intergroup competition and the evolution of ‘exploitative’ leadership, while converse patterns favoured increased intragroup competition and the emergence of ‘heroic’ leaders. We also found evidence of an alternative leader/follower ‘shared effort’ outcome. Parameters that favoured high contributing ‘heroic’ leaders, and low contributing followers, facilitated transitions to more peaceful outcomes. We outline and discuss the key testable predictions of our model for empiricists studying intergroup conflict in humans and animals. This article is part of the theme issue ‘Intergroup conflict across taxa’.

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Infertility and the Military Male

Cited by 7 publications

References 48 publications

Proinflammatory and Oxidative Stress States Induced by Human Papillomavirus and Chlamydia trachomatis Coinfection Affect Sperm Quality in Asymptomatic Infertile Men

Proinflammatory and Oxidative Stress States Induced by Human Papillomavirus and Chlamydia trachomatis Coinfection Affect Sperm Quality in Asymptomatic Infertile Men

High-Risk HPV with Multiple Infections Promotes CYP2E1, Lipoperoxidation and Pro-Inflammatory Cytokines in Semen of Asymptomatic Infertile Men

Leaders of war: modelling the evolution of conflict among heterogeneous groups

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