Reproductive and developmental toxicology: toxic solvents and gases

Vulimiri, Suryanarayana V.; Pratt, M. Margaret; Kulkarni, Shaila; Beedanagari, Sudheer; Mahadevan, B

doi:10.1016/b978-0-12-382032-7.10023-2

Cited by 3 publications

(1 citation statement)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, due to limitations in metabolite identification, only 1,3-bis(1,1-dimethylethyl)benzene, a phenylpropane, was identified as a significant metabolite contributing to the separation. Human exposure to benzene mainly occurs through inhalation, oral and dermal routes and is predominantly deposited in fatty tissues [51]. 1,3-bis(1,1-dimethylethyl) benzene has been detected in multiple bio-fluids, such as faeces [52] and saliva [53], however, this was the first instance that it was detected in human skin and wounds.…”

Section: Discussionmentioning

confidence: 99%

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Ashrafi

Muhamadali

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Profiling skin microbiome and metabolome has been utilised to gain further insight into wound healing processes. The aims of this multi-part temporal study in 11 volunteers were to analytically profile the dynamic wound tissue and headspace metabolome and sequence microbial communities in acute wound healing at days 0, 7, 14, 21 and 28, and to investigate their relationship to wound healing, using non-invasive quantitative devices. Metabolites were obtained using tissue extraction, sorbent and polydimethylsiloxane patches and analysed using GCMS. PCA of wound tissue metabolome clearly separated time points with 10 metabolites of 346 being involved in separation. Analysis of variance-simultaneous component analysis identified a statistical difference between the wound headspace metabolome, sites (P = 0.0024) and time points (P<0.0001), with 10 out of the 129 metabolites measured involved with this separation between sites and time points. A reciprocal relationship between Staphylococcus spp. and Propionibacterium spp. was observed at day 21 (P<0.05) with a statistical correlation between collagen and Propionibacterium (r = 0.417; P = 0.038) and Staphylococcus (r = -0.434; P = 0.03). Procrustes analysis showed a statistically significant similarity between wound headspace and tissue metabolome with non-invasive wound devices. This exploratory study demonstrates the temporal and dynamic nature of acute wound metabolome and microbiome presenting a novel class of biomarkers that correspond to wound healing, with further confirmatory studies now necessary.

show abstract

Section: Discussionmentioning

confidence: 99%

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Ashrafi

Muhamadali

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

Green Processes in Foodomics. Green Solvents for Sustainable Processes

Calvo‐Flores¹

2021

Comprehensive Foodomics

View full text Add to dashboard Cite

Increased time-to-pregnancy is associated with domestic work in South Africa

et al. 2016

View full text Add to dashboard Cite

BackgroundThe effects of female occupational exposures on fecundity have not been evaluated in South Africa. The aim of this study was to assess the effects of three specific occupational groups on time-to-pregnancy (TTP).MethodsThis cross-sectional study collected data, by means of a questionnaire, on 1210 women representative of a South African population, and sought information on: TTP for the most recent pregnancy, time-specific information on maternal factors and occupational exposures, as well as some paternal factors. Occupational exposure groups were determined using employment profile prior to the pregnancy. In the risk analysis, domestic workers and teachers were compared to administrative staff. Accidental and unplanned pregnancies were excluded from the analysis and participants who were never pregnant were censored. Discrete-time Cox regression models were built to estimate fecundability ratios (FR).ResultsThe median TTP in administrative workers, domestic workers and teachers was 4, 12 and 3 months respectively. After adjusting for a number of potential confounders, TTP was significantly related to occupation at the time of pregnancy attempt. Compared to administrative workers, domestic workers had a significantly lower per-cycle probability of conception (adjusted FR = 0.53; 95 CI 0.32–0.88). The per-cycle probability of conception in teachers compared to administrative workers was not significantly different (adjusted FR = 1.14; 95 CI: 0.75–1.72).ConclusionDomestic work was associated with prolonged TTP. Working as a domestic worker in South Africa may affect fecundity.

show abstract

Reproductive and developmental toxicology: toxic solvents and gases

Cited by 3 publications

References 98 publications

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Green Processes in Foodomics. Green Solvents for Sustainable Processes

Increased time-to-pregnancy is associated with domestic work in South Africa

Contact Info

Product

Resources

About