Evaluating associations of RNFL thickness and multifocal VEP with cognitive assessment and brain MRI volumes in older adults: Optic nerve decline and cognitive change (ONDCC) initiative

Shen, Ting; Sheriff, S.; You, Yuyi; Jiang, Jiyang; Schulz, Angela; Francis, Heather; Mirzaei, Mehdi; Saks, Danit; Chitranshi, Nitin; Gupta, Veer; Klistorner, Alexander; Wen, Wei; Sachdev, Perminder S.; Gupta, Vivek Kumar; Graham, Stuart L.

doi:10.1016/j.nbas.2022.100049

Cited by 3 publications

(5 citation statements)

References 64 publications

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“…Healthy elderly participants were recruited from the Optic Nerve Decline and Cognitive Change (ONDCC) study between July 2020 and August 2021 at Macquarie University Hospital Ophthalmology Clinic, Sydney, NSW, Australia [21]. All participants included were: (1) of both sexes and above the age of 50 years; (2) able to communicate in English and provide written informed consent; and (3) complete self-report questionnaires and psychometric assessment.…”

Section: Participantsmentioning

confidence: 99%

“…(2) ocular surgery within the past two months; (3) diagnosis of dementia, depression, neurotrauma, progressive malignancy, or any other major neurological disease; (4) intellectual disability. Details on the enrolment, composition and selective attrition are described previously [21]. Blood samples were also collected from all study participants.…”

Section: Participantsmentioning

confidence: 99%

“…All study participants were invited to undertake an MRI scan, and those who agreed were screened for contraindications (including pacemaker, metallic implant or foreign bodies, cochlear implants, ferromagnetic homeostatic clips, and claustrophobia) and were then scanned using a 3.0T GE DiscoveryTM MR750w Wide Bore MRI scanner (GE Healthcare, Milwaukee, WI, USA) located at the Macquarie Medical Imaging, Sydney, NSW, Australia. Details of the sequence have been described previously [21]. T1-weighted images were obtained using a Magnetization-prepared Rapid Acquisition Gradient Echo (MPRAGE) sequence with prospective motion correction (PROMO).…”

Section: Magnetic Resonance Imaging (Mri) Brain Imagingmentioning

confidence: 99%

“…An internal 6 × 6 grid was analysed from the posterior pole macular thickness map, as described previously [27,28]. The vessel density (VD) and vascular feature analyses were conducted utilising ImageJ software (National Institutes of Health, available at https://imagej.net/Fiji/Downloads) with a method adapted from Elfarnawany et al [21,29,30]. In brief, the macula OCTA image was binarized and skeletonized in the ImageJ.…”

Section: Oct and Octa Acquisition And Processingmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects

Shen,

Sheriff,

You

et al. 2024

Aging and disease

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Aging is associated with progressive brain atrophy and declines in learning and memory, often attributed to hippocampal or cortical deterioration. The role of brain-derived neurotrophic factor (BDNF) in modulating the structural and functional changes in the brain and visual system, particularly in relation to BDNF Val66Met polymorphism, remains underexplored. In this present cross-sectional observational study, we aimed to assess the effects of BDNF polymorphism on brain structural integrity, cognitive function, and visual pathway alterations. A total of 108 older individuals with no evidence of dementia and a mean (SD) age of 67.3 (9.1) years were recruited from the Optic Nerve Decline and Cognitive Change (ONDCC) study cohort. The BDNF Met allele carriage had a significant association with lower entorhinal cortex volume (6.7% lower compared to the Val/Val genotype, P = 0.02) and posterior cingulate volume (3.2% lower than the Val/Val group, P = 0.03), after adjusting for confounding factors including age, sex and estimated total intracranial volumes (eTIV). No significant associations were identified between the BDNF Val66Met genotype and other brain volumetric or diffusion measures, cognitive performances, or vision parameters except for temporal retinal nerve fibre layer thickness. Small but significant correlations were found between visual structural and functional, cognitive, and brain morphological metrics. Our findings suggest that carriage of BDNF Val66Met polymorphism is associated with lower entorhinal cortex and posterior cingulate volumes and may be involved in modulating the cortical morphology along the aging process.

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Section: Participantsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Magnetic Resonance Imaging (Mri) Brain Imagingmentioning

confidence: 99%

Section: Oct and Octa Acquisition And Processingmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects

Shen,

Sheriff,

You

et al. 2024

Aging and disease

Self Cite

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“…Between July 2020 and August 2021, participants were enrolled from the general community for participation in the Optic Nerve Decline and Cognitive Change (ONDCC) study [16]. This cross-sectional investigation of aging participants was conducted to examine the relationships between genetic profile and cognitive and ophthalmic parameters.…”

Section: Participant Recruitmentmentioning

confidence: 99%

The Association of APOE ε4 Allele with Retinal Layer Thickness and Microvasculature in Older Adults: Optic Nerve Decline and Cognitive Change Study

Sheriff,

Shen,

Saks

et al. 2023

JCM

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Purpose: To investigate the relationship between the apolipoprotein E (APOE) ε4 allele and retinal structural and vascular characteristics in older adult participants from several research studies. We also studied the relationship between these structural and vascular characteristics with multifocal visual evoked potential (mfVEP) indices, neuropsychological parameters and MRI brain volumes in these participants. Methods: In this study, 109 participants with a mean (SD) age of 67.1 (9.0) years were recruited. Participants were classified as APOE ε4 carriers or non-carriers based on the presence or absence of the ε4 allele. Baseline measurements included peripapillary retinal nerve fibre layer optical coherence tomography (RNFL OCT), and OCT–angiography (OCT-A) for evaluation of the retinal layer thickness and vessel density (VD) parameters. A multifocal visual evoked potential (mfVEP) test, including amplitude and latency, was used to assess the visual pathway function. Finally, cognitive function was evaluated using a battery of neuropsychological tests. OCT-A images were analysed in ImageJ to quantify VD in the superficial and deep vascular plexus and the size of the foveal avascular zone (FAZ). The relationship between carriers of APOE ε4 allele and these ocular parameters was analysed using generalised estimating equation (GEE) models and data adjusted for age, sex and inter-eye differences as within-subject variables (p < 0.05). Results: Twenty-four participants were APOE ε4 carriers. Temporal RNFL thickness was decreased in APOE ε4 carriers (p < 0.01). Vessel density between carriers and non-carriers was not significantly different at either the superficial or deep level. The FAZ area was significantly smaller in ε4 carriers in both superficial (p < 0.01) and deep layers (p < 0.003). Conclusions: Retinal abnormalities were present in participants with increased genetic risk of dementia due to presence of the ε4 allele. These findings provide preliminary evidence for their potential role in the diagnosis of dementia.

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Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer’s disease: a meta-analysis

Sheriff

Shen

Abdal

et al. 2023

Neural Regeneration Research

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Evaluating associations of RNFL thickness and multifocal VEP with cognitive assessment and brain MRI volumes in older adults: Optic nerve decline and cognitive change (ONDCC) initiative

Cited by 3 publications

References 64 publications

Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects

Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects

The Association of APOE ε4 Allele with Retinal Layer Thickness and Microvasculature in Older Adults: Optic Nerve Decline and Cognitive Change Study

Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer’s disease: a meta-analysis

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