Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer’s disease: a meta-analysis

Sheriff, S.; Shen, Ting; Abdal, Sandra; Saks, Danit; Mirzaei, Mehdi; Gupta, Veer Bala; Chitranshi, Nitin; You, Yuyi; Schultz, Angela; Graham, Stuart L.; Gupta, V.

doi:10.4103/1673-5374.371380

Cited by 3 publications

(4 citation statements)

References 105 publications

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“…We did, however, observe that the internal retinal layers (GCL, IPL) showed the greatest discriminant capacity in practically all of the Posterior Pole protocol cells, in line with the conclusions drawn in studies such as [11,14], which report significant differences in GC-IPL thickness in AD patients.…”

Section: Discussionsupporting

confidence: 90%

“…The literature to date encompasses extensive reviews that elucidate changes in retinal thickness in both MS [8,10] and AD [11,12]. To the best of our knowledge, however, there are no prior studies that compare the differential diagnostic capacity of OCT in relation to these two diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Most recent studies comparing control subjects with AD patients demonstrate the existence of RNFL thinning in both the pRNFL (overall and predominantly in the superior and inferior sectors [11][12][13]) and in the inner retinal layers at the level of the macula: mRNFL, GCL and IPL [11,14]. While studies detecting alterations in the pRNFL are the most numerous, other papers consider that measuring the macula may be more effective in assessing neurodegenerative changes [15].…”

Section: Introductionmentioning

confidence: 99%

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Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

Garcia-Martin,

Jimeno-Huete,

Dongil-Moreno

et al. 2023

Biomedicines

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Multiple sclerosis (MS) and Alzheimer’s disease (AD) cause retinal thinning that is detectable in vivo using optical coherence tomography (OCT). To date, no papers have compared the two diseases in terms of the structural differences they produce in the retina. The purpose of this study is to analyse and compare the neuroretinal structure in MS patients, AD patients and healthy subjects using OCT. Spectral domain OCT was performed on 21 AD patients, 33 MS patients and 19 control subjects using the Posterior Pole protocol. The area under the receiver operating characteristic (AUROC) curve was used to analyse the differences between the cohorts in nine regions of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and outer nuclear layer (ONL). The main differences between MS and AD are found in the ONL, in practically all the regions analysed (AUROCFOVEAL = 0.80, AUROCPARAFOVEAL = 0.85, AUROCPERIFOVEAL = 0.80, AUROC_PMB = 0.77, AUROCPARAMACULAR = 0.85, AUROCINFERO_NASAL = 0.75, AUROCINFERO_TEMPORAL = 0.83), and in the paramacular zone (AUROCPARAMACULAR = 0.75) and infero-temporal quadrant (AUROCINFERO_TEMPORAL = 0.80) of the GCL. In conclusion, our findings suggest that OCT data analysis could facilitate the differential diagnosis of MS and AD.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

Garcia-Martin,

Jimeno-Huete,

Dongil-Moreno

et al. 2023

Biomedicines

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“…15,16 By detecting compromised perfusion sites in both superficial and deep capillary plexi, OCTA also offers valuable depth information regarding the severity of impaired perfusion. 17 Consequently, OCTA has gained widespread usage in the diagnosis of several diseases, including optic neuritis, 18 Alzheimer’s disease, 19 diabetic retinopathy, 20 thyroidrelated ophthalmopathy, 21 and Parkinson’s disease. 22 In light of its noninvasive nature and clinical viability, OCTA was chosen as the preferred retinal imaging technique over FFA to examine alterations in retinal and choroidal thickness as well as vascular density among SLE patients in the present study.…”

Section: Discussionmentioning

confidence: 99%

Changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus: Assessed by optical coherence tomography angiography

Liu,

Zhang,

et al. 2023

Lupus

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Objective The aim was to investigate the changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus (SLE) using optical coherence tomography angiography (OCTA). Methods Twenty-nine patients with SLE (29 eyes) and 25 control subjects (25 eyes) were enrolled. SLE activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Retinal thickness (RT), inner retinal thickness (IRT), outer retinal thickness (ORT), choroidal thickness (ChT), retinal superficial vascular density (SVD), retinal deep vascular density (DVD), choriocapillary vascular density (CCVD), foveal avascular zone (FAZ), superficial FAZ (sFAZ), and deep FAZ (dFAZ) were measured using OCTA. The retinal and choroidal thickness and vascular density between the control group and SLE group were compared. The relationships between SLEDAI scores and the retinal and choroidal thickness and vascular density in SLE group were analyzed. Results The SVD was significantly increased, and the DVD and CCVD were significantly decreased in the SLE group compared to the control group ( p < .05). The results of receiver operating characteristic (ROC) showed that the area under the curve (AUC) values of SVD, DVD, and CCVD were 0.873, 0.729, and 0.727, indicating a high accuracy in discriminating patients with SLE from controls. Correlation analysis showed that the SLEDAI scores were positively correlated with dFAZ ( r = 0.589, p = .001) and FAZ ( r = 0.451, p = .018), and negatively correlated with DVD ( r = −0.491, p = .009) and CCVD ( r = −0.521, p = .005). Conclusions DVD and CCVD were decreased in the SLE and might be related to the disease activity. SVD, DVD, and CCVD may hold promise in the discovery of biomarkers for diagnosing SLE.

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Optical coherence tomography as a potential surrogate marker of dopaminergic modulation across the life span

Elmers,

Colzato,

Ziemssen

et al. 2024

Ageing Research Reviews

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Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer’s disease: a meta-analysis

Cited by 3 publications

References 105 publications

Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

Changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus: Assessed by optical coherence tomography angiography

Optical coherence tomography as a potential surrogate marker of dopaminergic modulation across the life span

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