Evaluasi Penggunaan Antibiotik pada Pasien Rawat Inap di Bangsal Penyakit Dalam RSUD. Dr. H. Abdul Moeloek Provinsi Lampung

Abstract

The high prevalence of infectious disease in Indonesia causes increased use of antibiotics. It has serious consequences since it can cause germicidal resistance rapidly increased, significant morbidity and mortality, as well as high additional medical costs per year. This study aims to evaluate the appropriateness of antibiotic use inpatients in the internal medicine ward of Dr. H. Abdul Moeloek in Lampung Province. This research was observational (non-experimental) with a descriptive evaluative research design. The data were obtained from the retrospective tracing of medical records that collected by a purposive sampling technique on July-December 2017. A total of 163 inclusion samples are analyzed qualitatively and quantitatively. The qualitative analysis uses standard guidelines for the use of antibiotics and quantitative analysis uses the anatomical therapeutic chemical (ATC)/Defined Daily Dose (DDD) method. The results showed that out of 168 medical records, 19 types of antibiotics were used with a 118.57 DDD value of 100 patient days. The most widely prescribed was ceftriaxone (49.09%). The highest number of infections was diabetic ulcers with an incidence of 42 cases (25%). Out of 168 evaluated cases, 166 cases (98.8%) were appropriate indication, 168 cases (100%) were appropriate patients, 150 cases (89,29%) were appropriate medication, and 89 cases (52,97%) were appropriate dosage. These results indicated that the use of antibiotics inpatients in the internal medicine ward of Dr. H. Abdul Moeloek in Lampung Province were rational but it was necessary to consider selectivity regarding the choice of antibiotic use for infected patients.

Optimizing antibiotic use in Indonesia: a systematic review and synthesis of current evidence to inform opportunities for intervention

“…A total of 49 reports reported data on the appropriateness of antibiotic prescribing, of which 18 33, 39–55 (3167 prescriptions) used Gyssens method and 31 (7826 prescriptions) 20, 56–85 used reference guidelines. Most were conducted in hospitals (37 reports, 74.0%), in Java (33 reports, 66.0%), and in adults (29 reports, 58.0%) ( Table S5-S6 ).…”

“…A total of 20 reports (5 193 626 patients) reported data on antibiotic consumption. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Most of the studies were conducted in hospital settings (16 reports, 76.2%), in Java (14 reports, 66.7%), and between 2016-2021 (17 reports, 81.0%; Table S4). The pooled estimate of overall antibiotic…”

Studi Literatur Rasionalitas, Dan Pola Sensitivitas Terhadap Antibiotik Pada Bakteri Staphylococcus Aureus Penyebab Infeksi Gangren Diabetes Melitus

“…[11] Tabel 1. Hasil uji rasionalitas antibiotic [12,11,13,15] No parenteral. [11] Penelitian yang dilakukan oleh Arifin [13] terkait rasionalitas penggunaan antibiotik yaitu tepat indikasi (94,19%), tepat pasien (100%), tepat dosis (100%), tepat obat (100%), tepat interaksi obat (3,12%).…”

“…[13] . Penggunaan Antibiotik yang dipakai di beberapa rumah sakit di Indonesia yang telah mengalami resistensi yaitu ceftriaxon, cotrimoxazole, [4] benzylpenicillin erythromycin, ampicillin, [14] cloramfenicol cefoperazone, meropenem, cefixime, gentamicin, [15] ceftazidime, ciprofloxacin, streptomycin, lincomycin, [16] cefotaxime. [17] Data uji sensitivitas bakteri S.aureus Salim [16] diketahui pada uji sensitivitas antibiotik diketahui bakteri S.aureus dan pemakaian antibiotik dalam waktu yang lama.…”

“…[17] Data uji sensitivitas bakteri S.aureus Salim [16] diketahui pada uji sensitivitas antibiotik diketahui bakteri S.aureus dan pemakaian antibiotik dalam waktu yang lama. [15] Penelitian yang telah dilakukan oleh Gaol [17] , diperoleh hasil uji sensitivitas antibiotik terhadap bakteri S.aureus pada luka gangren pasien DM yaitu diperoleh hasil bakteri S.aureus mengalami resistensi terhadap antibiotik cefixime (100%), ampicillin (90%), dan erythromycin (65%). [17] Hal ini sesuai dengan penelitian yang dilakukan Handayani [8] bakteri antibiotik yang tidak rasional.…”