2018
DOI: 10.3390/md16040136
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Eurotiumins A–E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452

Abstract: Three new prenylated indole 2,5-diketopiperazine alkaloids (1–3) with nine known ones (5–13), one new indole alkaloid (4), and one new bis-benzyl pyrimidine derivative (14) were isolated and characterized from the marine-derived fungus Eurotium sp. SCSIO F452. 1 and 2, occurring as a pair of diastereomers, both presented a hexahydropyrrolo[2,3-b]indole skeleton. Their chemical structures, including absolute configurations, were elucidated by 1D and 2D NMR, HRESIMS, quantum chemical calculations of electronic c… Show more

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Cited by 42 publications
(46 citation statements)
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References 30 publications
(37 reference statements)
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“…The fungus Eurotium sp. SCSIO F452 was cultured and extracted as previously described (Zhong W.-M. et al, 2018).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The fungus Eurotium sp. SCSIO F452 was cultured and extracted as previously described (Zhong W.-M. et al, 2018).…”
Section: Methodsmentioning
confidence: 99%
“…Motivated by the fascinating secondary metabolites produced by the fungi Eurotium spp., we have launched a chemical investigation on a marine-derived fungus isolated from a South China Sea sediment sample, Eurotium sp. SCSIO F452, and found a series of prenylated DKPs, prenyl benzaldehyde derivatives, especially three pairs of spirocyclic diketopiperazine-anthraquinone enantiomers variecolortins A–C (Wang et al, 2013; Zhong W. et al, 2018; Zhong W.-M. et al, 2018). In order to enrich and improve the chemical diversity of this fungus, we carried out a further chemical study on the Eurotium sp.…”
Section: Introductionmentioning
confidence: 99%
“…Diketopiperazines are widespread marine fungal products with different biological activities, including free radical scavenging and neuroprotection [ 11 , 12 ]. Gliotoxin from Pseudallescheria sp., neoechinulin E, and cryptoechinulin D, exhibited DPPH scavenger activity with IC 50 values of 5.2, 46.0, and 23.6 µM, respectively [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…SCSIO F452. They showed significant radical scavenging activities in a DPPH assay [76]. Marine fungi also produce indole-derived alkaloids.…”
Section: Alkaloidsmentioning
confidence: 99%