Eugenol and thymol as potential inhibitors for polymicrobial oral biofilms: An in vitro study

Utami, Diyah; Pratiwi, Sylvia Utami Tunjung; Haniastuti, Tetiana; Hertiani, Triana

doi:10.4103/jioh.jioh_247_20

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…35 In addition to their impact on cell surface hydrophobicity, thymol, eugenol, C-10 Massoialactone, zerumbone, and cinnamaldehyde were observed to inhibit biofilm formation. [36][37][38][39] This suggests that the phenolic contents, specifically in eugenol and thymol, were essential in inhibiting biofilm formation and Streptococcal aggregation. It was also discovered that the cell surface hydrophobicity influenced the formation of oral streptococci biofilms on hard surfaces.…”

Section: Resultsmentioning

confidence: 99%

“…Other include eugenol and thymol, which have been found effective against biofilms of Streptococcus sanguinis, Lactobacillus acidophilus, Actinomyces viscosus, and Streptococcus mutans, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans. 23,24 C-10 massoialactone can degrade polymicrobial biofilms such as Streptococcus mutans, Lactobacillus acidophilus, Streptococcus sanguinis and Actinomyces viscosus. In addition, zerumbone showed an antibiofilm effect on Streptococcus sanguinis and Lactobacillus acidophilus.…”

Section: Introductionmentioning

confidence: 99%

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Correlation Analyses of the Oral Biofilm Growth Inhibition towards Hydrophobicity Reduction of Oral Pathogenic Bacteria

2023

TJNPR

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Subsequently, other Gram-positive bacteria like Actinomyces viscosus, Actinomyces israelii, and Actinomyces gerencseriae, as well as Gramnegative bacteria like Veillonella parvula, join the biofilm community. 5 The supragingival dental plaque predominantly hosts oral bacterial species such as Lactobacilli, Streptococci, and Bifidobacterial. [6][7][8][9] These bacteria and many other commensal species form a complex biofilm community in the oral cavity. While most of these species are commensal, some act as low-level opportunistic pathogens and contribute to the development of dental caries. 5,[10][11][12][13][14] Several factors influence the composition and growth of the oral microbiota, including drug treatment, dietary habits, systemic diseases, endogenous nutrients, and the host's immune system. 4,[15][16][17] Saliva plays a crucial role in providing nutrients for the oral microbial ecosystem. However, a decrease in saliva production can increase opportunistic pathogens, such as fungi and non-pathogenic bacteria. Systemic diseases that elevate glucose levels in saliva also affect bacterial nutrition. These changes in the oral ecosystem directly impact the dysbiosis of bacterial biofilms and contribute to dental deterioration. 16,18 The ability of bacteria to adhere to a surface is crucial for forming biofilms. In the case of oral bacteria, their attachment to the tooth surface is determined by the interaction between bacterial cells and the surface. 19 This initial attachment is facilitated by hydrophobic interactions, which play a significant role in the process. The success of this interaction depends on factors such as the structure of the bacterial

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation Analyses of the Oral Biofilm Growth Inhibition towards Hydrophobicity Reduction of Oral Pathogenic Bacteria

2023

TJNPR

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“…Hamzah et al investigated various concentrations of these phenolic compounds against Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa biofilm. The concentration of 0.96% w / v proved a high inhibition against the selected bacteria, with thymol showing the highest ability to cease a biofilm formation [ 63 , 64 ]. The antibacterial activity of phenolic compounds is attributed to phenolic hydroxyl in their structure [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Biofilm Formation Reduction by Eugenol and Thymol on Biodegradable Food Packaging Material

Pleva

Bartošová

Máčalová

et al. 2021

Foods

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Biofilm is a structured community of microorganisms adhering to surfaces of various polymeric materials used in food packaging. Microbes in the biofilm may affect food quality. However, the presence of biofilm can ensure biodegradation of discarded packaging. This work aims to evaluate a biofilm formation on the selected biodegradable polymer films: poly (lactic acid) (PLA), poly (butylene adipate-co-terephthalate) (PBAT), and poly (butylene succinate) (PBS) by selected bacterial strains; collection strains of Escherichiacoli, Staphylococcusaureus; and Bacillus pumilus, Bacillussubtilis, Bacillustequilensis, and Stenotrophomonasmaltophilia isolated from dairy products. Three different methods for biofilm evaluation were performed: the Christensen method, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and fluorescence microscopy. High biofilm formation was confirmed on the control PBS film, whereas low biofilm formation ability was observed on the PLA polymer sample. Furthermore, the films with incorporated antimicrobial compounds (thymol or eugenol) were also prepared. Antimicrobial activity and also reduction in biofilm formation on enriched polymer films were determined. Therefore, they were all proved to be antimicrobial and effective in reducing biofilm formation. These films can be used to prepare novel active food packaging for the dairy industry to prevent biofilm formation and enhance food quality and safety in the future.

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Formulation and Development of Clove and Coriander Combination Herbal Dental Anticaries Gel and Evaluation of its Antimicrobial Activity

Paramita,

Julekha,

Kumar

2024

CTM

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Background: Dental caries is one of the Periodontal diseases that has been recognized as a major public health problem for decades throughout the world. It occurs in all groups, ethnicities, races, and genders at all socioeconomic levels. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than synthetic ones. Clove and coriander oil are established herbal drugs for periodontal diseases. Objective: This research work was intended to formulate a dental gel containing clove and Coriander as the major constituents and evaluate it for dental caries treatment. Both of the herbal oils have a vast range of antimicrobial activity against a great number of periodontal pathogens; therefore, they are used for periodontitis treatment. Methods: The combination gel was prepared using carbopol 934 as a gelling agent, clove oil and coriander oil as therapeutic constituents, polyethylene glycol as a co-solvent, methyl paraben and propyl paraben as a preservative and a required quantity of distilled water as vehicle. Results: The gel was analyzed for various properties like antimicrobial activity, pH, spreadability, extrudability, drug content etc., and it was shown that the combination gel is a satisfactory dosage form that is used in periodontitis treatment. The combination gel revealed the ZI ( zone of inhibition ) of about 22.05±0.04 mm. Conclusion: The present study concluded that the combination gel preparations of clove oil and coriander oil reported satisfactory physicochemical properties along with good drug content compared to the single gel preparation.

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Eugenol and thymol as potential inhibitors for polymicrobial oral biofilms: An in vitro study

Cited by 4 publications

References 36 publications

Correlation Analyses of the Oral Biofilm Growth Inhibition towards Hydrophobicity Reduction of Oral Pathogenic Bacteria

Correlation Analyses of the Oral Biofilm Growth Inhibition towards Hydrophobicity Reduction of Oral Pathogenic Bacteria

Biofilm Formation Reduction by Eugenol and Thymol on Biodegradable Food Packaging Material

Formulation and Development of Clove and Coriander Combination Herbal Dental Anticaries Gel and Evaluation of its Antimicrobial Activity

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