Étude prospective comparant l’efficacité de la vitrification ovocytaire en système fermé ou en système ouvert

Sarandi, S; Herbemont, C.; Sermondade, Nathalie; Benoit, A.; Sonigo, Charlotte; Poncelet, C.; Benard, Julie; Gronier, Héloïse; Boujenah, J.; Grynberg, M.; Sifer, C.

doi:10.1016/j.gyobfe.2016.02.003

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…In total, 2577 oocytes (1330 for open and 1247 for closed vitrification, respectively) and 3640 embryos (2024 for open and 1616 for closed vitrification, respectively; data from one study [ 22 ] was not counted because the author didn’t mention the number of embryos thawed in the study) were included for quantitative analysis. The language of the included studies was English, except for one in French [ 21 ]. The participants in these studies mainly came from Europe, North America, and East Asia.…”

Section: Resultsmentioning

confidence: 99%

“…The basic characteristics of the selected literatures are listed on Table 1 . Results of the methodological quality assessment showed that 3 of the prospective studies were of low risk of bias [ 8 , 17 , 22 ], 2 were moderate [ 13 , 16 ] and 3 were of serious risk of bias [ 20 , 21 , 23 ]. The results of the quality assessment of the included retrospective studies were shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Regarding embryo cryopreservation, several studies reported comparable results between open and closed vitrification on survival rates after thawing [ 13 – 18 ]; while others demonstrated that closed vitrification outperformed the open one [ 19 , 20 ]. For oocytes vitrification, some suggested that ‘open’ was better than ‘closed’ in post-thawing survival rates [ 7 , 8 , 21 ]; others found no statistical differences between these two methods [ 22 , 23 ]. In addition, the rest of the embryologic and clinical outcomes differed from each other according to the studies mentioned above.…”

Section: Introductionmentioning

confidence: 99%

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Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Cai

Niringiyumukiza

et al. 2018

Reprod Biol Endocrinol

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BackgroundThe objective of this study was to carry out a systematic review and meta-analysis of embryologic and clinical outcomes following open versus closed vitrification of human oocytes and embryos.MethodsAn electronic literature search was conducted in main electronic databases up to June 30, 2018 using the following key terms: ‘oocyte’, ‘embryo’, ‘blastocyst’, ‘vitrification’, ‘cryopreservation’, ‘device’, ‘survival rate’, ‘pregnancy rate’, etc. A meta-analysis was performed using a random effect model to estimate the value of risk ratios (RRs) and 95% confidence interval (CI). Subgroup analyses and sensitivity analyses were carried out to further confirm the results.ResultsTwelve (Eight prospective and four retrospective) studies comparing open versus closed vitrification of human oocytes or embryos were included. For prospective studies on oocytes, no evidence for a significant difference in cryosurvival rate (RR = 0.91, 95% CI: 0.80–1.03, P = 0.14; n = 2048) or clinical pregnancy rate (RR = 1.29, 95% CI: 0.80–2.06, P = 0.30; n = 150) was observed. Additionally, there were no significant differences between the two methods concerning secondary endpoints included positive βHCG rate, implantation rate, miscarriage rate, ongoing pregnancy rate, live birth rate, cancellation rate, babies born per transferred blastocysts, or multiple birth rate (P > 0.05). The results of the retrospective studies were similar as the prospective studies.ConclusionsIt is still impossible to conclude that closed vitrification system could be a substitution for open system in human oocyte and embryo cryopreservation based on current evidence. Therefore, more well-designed prospective studies addressing these issues are still warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Cai

Niringiyumukiza

et al. 2018

Reprod Biol Endocrinol

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Vitrification of human immature oocytes before and after in vitro maturation: a review

Khalili

Shahedi

Ashourzadeh

et al. 2017

J Assist Reprod Genet

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The use of immature oocytes subjected to in vitro maturation (IVM) opens interesting perspectives for fertility preservation where ovarian reserves are damaged by pathologies or therapies, as in PCO/PCOS and cancer patients. Human oocyte cryopreservation may offer some advantages compared to embryo freezing, such as fertility preservation in women at risk of losing fertility due to oncological treatment or chronic disease, egg donation and postponing childbirth. It also eliminates religious and/or other ethical, legal, and moral concerns of embryo freezing. In addition, a successful oocyte cryopreservation program could eliminate the need for donor and recipient menstrual cycle synchronization. Recent advances in vitrification technology have markedly improved the oocyte survival rate after warming, with fertilization and implantation rates comparable with those of fresh oocytes. Healthy live births can be achieved from the combination of IVM and vitrification, even if vitrification of in vivo matured oocytes is still more effective. Recently, attention is given to highlight whether vitrification procedures are more successful when performed before or after IVM, on immature GV-stage oocytes, or on in vitro matured MII-stage oocytes. In this review, we emphasize that, even if there are no differences in survival rates between oocytes vitrified prior to or post-IVM, reduced maturation rates of immature oocytes vitrified prior to IVM can be, at least in part, explained by underlying ultrastructural and biomolecular alterations.

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Gamete and Embryo Manipulation

Rosen¹,

Yang²,

Marsh³

et al. 2019

Yen and Jaffe's Reproductive Endocrinology

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Étude prospective comparant l’efficacité de la vitrification ovocytaire en système fermé ou en système ouvert

Cited by 5 publications

References 15 publications

Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Vitrification of human immature oocytes before and after in vitro maturation: a review

Gamete and Embryo Manipulation

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