Etoricoxib-induced Acute Generalized Exanthematous Pustulosis

Mäkelä, Leeni; Lammintausta, Kaija

doi:10.2340/00015555-0381

Cited by 21 publications

(8 citation statements)

References 9 publications

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“…It can be distressing for these patients to have these symptoms reproduced, as may happen during a DPT, and hence testing is often declined. Patch test can be useful in evaluation of FDE, but sensitivity of the test remains unknown and probably varies for different drugs . In our study, one patient with paracetamol‐induced FDE proven on DPT had negative patch test results.…”

Section: Discussionmentioning

confidence: 69%

“…Its potential to cause adverse reactions must not be neglected. These include immediate hypersensitivity reactions, FDE, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis . Cross reactivity between COX2‐specific inhibitors in FDE is not well‐studied but it has been previously reported that a patient with etoricoxib‐induced FDE was able to tolerate celecoxib, a COX2‐specific inhibitor with similar pharmacological action but different chemical structure .…”

Section: Discussionmentioning

confidence: 99%

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An update of fixed drug eruptions in Singapore

Heng

Yew

Lim

et al. 2014

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

An update of fixed drug eruptions in Singapore

Heng

Yew

Lim

et al. 2014

Acad Dermatol Venereol

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“…There are various cutaneous adverse drug reactions reported following intake of etoricoxib ranging from erythema, angioedema, acute generalized exanthematous pustulosis and erythema multiforme like eruptions. 2,[7][8][9] Identification and discontinuation of offending drug helps in resolution of the lesions. No specific treatment is required; topical corticosteroids and oral antihistamincs may give symptomatic relief from itching.…”

Section: Discussionmentioning

confidence: 99%

A possible case of etoricoxib induced fixed drug eruption

Apoorva¹,

Girish²,

Manjunath³

2019

Int J Basic Clin Pharmacol

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Fixed drug eruption (FDE) is a most commonly with adverse drug reaction seen with use of Non-steroidalanti-inflammatory drugs (NSAIDs) in particular nimesulide followed by antibiotics and anticonvulsants. Etoricoxib is a selective cyclo-oxygenase isoenzyme-2 inhibitor which is superior to conventional NSAIDs and causes less side effects. Authors present a case of fixed drug eruption due to etoricoxib in a male patient. A 50-year-old patient presented to Outpatient Department (OPD) of Dermatology of a Tertiary Care Hospital with complains of skin rashes over lips, oral cavity, trunk, both the upper and lower limbs, palm, soles, scrotum and glans penis since a week. The detailed history of the patient revealed the use of etoricoxib a week back, prescribed for low back pain. It was suspected that the cutaneous drug reaction was due to the use of etoricoxib. The suspected drug etoricoxib was stopped, patient was admitted and managed symptomatically. The above reaction was assessed to be “possible” as per WHO-UMC and Naranjo causality scale, “moderate” on Hartwig’s scale and “Probably preventable” according to Schumock and Thornton criteria. This case reporting was done to sensitize the prescribers regarding rare side effects of the above drug and the need to confirm past history of drug reaction before prescription.

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“…Only isolated case reports of serious cutaneous drug reactions, such as erythema exsudativum multiforme-like exanthema or acute generalized exanthematous pustulosis, have been published so far. 7,8 We are reporting on the successful treatment with infliximab of a case of TEN following treatment with etoricoxib and wish in this connection to again point out the evident and rapid efficacy of TNF-a blockade.…”

mentioning

confidence: 99%

“…Etoricoxib (Arcoxia; MSD, Haar, Germany) is a highly‐selective cyclooxygenase‐2 inhibitor NSAID and is used in clinical practice mainly for the treatment of osteoarthritis, rheumatoid arthritis and pain. Only isolated case reports of serious cutaneous drug reactions, such as erythema exsudativum multiforme‐like exanthema or acute generalized exanthematous pustulosis, have been published so far 7,8 …”

mentioning

confidence: 99%