Background: Over the years, acyclovir has been the oral antiviral agent approved for the treatment of patients with acute herpes zoster,Its effectiveness in lessening the acute signs and symptoms of herpes zoster has been established but the effects on post herpetic neuralgia are less clear cut. Famciclovir is a new member of guanine nucleoside family of drugs. It is a well absorbed oral form of penciclovir with longer half life. This was a open comparative randomized study carried out to compare the safety and efficacy of famciclovir administered at 250mg thrice daily with acyclovir 800mg five times daily for the treatment of acute uncomplicated herpes zoster in immunocompetent individuals aged above 40 years. AIM:To assess the clinical profile of Herpes zoster, compare the efficacy and safety of acyclovir and famciclovir in the treatment of herpes zoster and to describe the effectiveness of acyclovir and famciclovir preventing post herpetic neuralgia. Methods:A total of 100 newly zoster were randomized in 1:1 ratio into acyclovir and famciclovir groups after inclusion criteria were satisfied.Treatment was initiated within 72 hrs of onset of symptoms and was continued for 7 days and evaluated at the end of each week up to six weeks period for full crusting of the lesions, complete healing of the lesion and loss of acute pain.Results: It was observed that famciclovir was as effective as acyclovir with no significant difference in time taken for full crusting, complete healing of lesions or loss of acute pain. Famciclovir was well tolerated with a better safety profile comparable to that of acyclovir. Constipation, headache, nausea and vomiting were the most commonly reported adverse effects, but constipation was considered to have a possible relationship to treatment. Conclusion:In conclusion, oral famciclovir administered three times daily for 7 days during acute zoster infection is as effective as acyclovir, administered 800mg five times daily.In addition it offers significant benefit by providing a well tolerated, cost effective, convenient dosage regime and accelerated rate of lesion resolution and a reduced duration of PHN.
Glomus tumors are benign localized tumors of the skin accounting for 1% to 2% of all soft tissue tumors. They may present as a solitary tumor or multiple tumors, termed glomangioma. They are usually solitary, small bluish, painful lesions usually located under the fingernails. They are more common in females than in males. Multiple lesions are slightly more common in males and they develop 10-15 years earlier than single lesions; about one third of the cases of multiple tumors occur in those younger than 20 years. Multiple tumors are less likely to be painful. Congenital glomus tumors are rare; they are plaque like in appearance and are considered a variant of multiple glomus tumors. Familial glomangiomas have been associated with a variety of deletions in the glomulin gene, and are inherited in an autosomal dominant manner, with incomplete penetrance. A 30 year-oldmale patient presented with asymptomatic multiple lesions of about 2 years duration. Clinical examination demonstrated numerous greenish blue nodules overchest, back, lower extremity. Histological examination revealed non-capsulated inflammatory infiltrate with multiple irregular vascular channels lined with endothelial cells. Multiple RBCs are also, present within the vascular channels consistent with glomangioma. We are reporting a rare case of glomangioma.
PurposeThe purpose of this paper is the physico-chemical, microbiological, colorimetric, sensorial characterization of choris, a traditional smoked pork sausage produced in the state of Goa (India), including its storage stability (0–180 days) at room temperature, aiming at the geographical indication certification and entrepreneurship prospects.Design/methodology/approachA total of 48 samples of “choris” were collected from 24 villages of Goa and were analyzed at different intervals (0–180 days) for physico-chemical, proximate, microbiological, colorimetric and sensory attributes during the storage at room temperature.FindingsThe mean pH of 4.45 and water activity (aw) of 0.78 were recorded. The pH, tyrosine value, fat percentage and free fatty acid content registered a significant increase, whereas moisture content, aw and moisture–protein ratio reduced as storage progresses. The colorimetric values lightness (L*), hue angle (H*) and redness index values reduced significantly during storage. The mean total viable count, yeast and mold, and lactic acid bacteria count were found to proliferate significantly as storage advanced. Nevertheless, the hedonic scores not reaching an unacceptable level (= 4) at the end of the storage period.Originality/valueIn accordance with the various parameters adopted during the study, choris could be characterized as “naturally fermented dry smoked” sausages, which were shelf-stable at room temperature for 180 days. The product characterization of choris is essential to guarantee the genuineness, safety and consumer's acceptability. This study will also rebound in an augmented uniformity of the product, which will favor the geographical indication certification and the entrepreneurship prospects of this traditional product.
BACKGROUND: Vitiligo is a common, acquired discoloration of the skin, characterized by well-circumscribed ivory or chalky white macules which are flush to the skin surface 1. It affects atleast 0.5-1% of the total population 2. It is commonly distributed in the peri-orificial areas, trunk, extensor surface of extremities, flexor wrists and axillae. It results from a cellular autoimmune phenomenon that causes destruction of melanocytes. AIMS: To compare the quality of life between vitiligo patients and healthy individuals and to compare the quality of life between males and females vitiligo patients. MATERIALS AND METHODS: A comparative study of Twenty eight patients with vitiligo attending the Out Patient Department of Skin and STD department at KIMS Hospital, Bangalore was done between April and May 2013. RESULTS: A total of 13 male patients, 15 female patients and 15 male controls and 15 female controls, all within the age group of 16-50 years were taken and their DLQI scores were tabulated and analysed as follows: The mean and standard deviation of scores for all patients is 5.14±4.44, and that for controls is 0. This shows higher impairment in quality of life for patients as compared to controls and the results are statistically significant (Z value=2.08 and p value<0.05). CONCLUSION: 1. Quality of life was impaired in vitiligo patients. 2. Among the patients, females had poorer quality of life. 3. Quality of life was more impaired in younger patients. 4. Impairment of quality of life was higher in unmarried patients than among married patients.
Fixed drug eruption (FDE) is a most commonly with adverse drug reaction seen with use of Non-steroidalanti-inflammatory drugs (NSAIDs) in particular nimesulide followed by antibiotics and anticonvulsants. Etoricoxib is a selective cyclo-oxygenase isoenzyme-2 inhibitor which is superior to conventional NSAIDs and causes less side effects. Authors present a case of fixed drug eruption due to etoricoxib in a male patient. A 50-year-old patient presented to Outpatient Department (OPD) of Dermatology of a Tertiary Care Hospital with complains of skin rashes over lips, oral cavity, trunk, both the upper and lower limbs, palm, soles, scrotum and glans penis since a week. The detailed history of the patient revealed the use of etoricoxib a week back, prescribed for low back pain. It was suspected that the cutaneous drug reaction was due to the use of etoricoxib. The suspected drug etoricoxib was stopped, patient was admitted and managed symptomatically. The above reaction was assessed to be “possible” as per WHO-UMC and Naranjo causality scale, “moderate” on Hartwig’s scale and “Probably preventable” according to Schumock and Thornton criteria. This case reporting was done to sensitize the prescribers regarding rare side effects of the above drug and the need to confirm past history of drug reaction before prescription.
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