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Coronavirus-induced COVID-19, a highly contagious respiratory illness first originated from Wuhan city of Hubei province, China, and has affected 235 countries across the globe. The COVID-19 is mainly transmitted by the droplets of an infected person when they cough, sneeze, or exhale. Currently, there are no specific drugs licensed for the effective treatment or prevention of COVID-19 and the treatment is mainly focused on controlling symptoms. Identification of small bioactive plant molecules that specifically target whole viral replication apparatus have great potential towards the development of antiviral drug discovery. This communication describes our current understanding of SARS-nCoV interaction with some herbal bioactive compounds of A. annua including sesquiterpenes, flavonoids and phenolics using in silico approach. Int. J. Appl. Sci. Biotechnol. Vol 8(4): 374-393

Investigation and analysis of a ferroelectric material-based dopingless nanotube tunnel field-effect transistor are conducted using a lead zirconate titanate (PZT) gate stack to induce negative capacitance in the device. Landau-Khalatnikov equations are used in deriving the parameter values of the ferroelectric material to ensure accurate results. The nanotube structure of the tunnel field-effect transistor allows for better electrostatic control owing to its gate-all-around structure. Incorporation of negative capacitance further reduces the voltage supply requirement and power consumption of the structure while simultaneously improving switching. In addition, the device is studied for varying thicknesses of the dielectric PZT material. The threshold voltage of the device under study was calculated as 0.281 V, and the average subthreshold slope of the device was reduced to 18.271 mV/decade, far below the thermionic limit of 60 mV/decade. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.