Repurposing Artemisia annua L. Flavonoids, Artemisinin and Its Derivatives as Potential Drugs Against Novel Coronavirus (SARS –nCoV) as Revealed by In-Silico Studies

Kumar, K V S Hari; Apoorva,; Sharma, Lakee; Pandey, Neha; Meena, Raj Kumar; Pandey-Rai, Shashi

doi:10.3126/ijasbt.v8i4.33667

Cited by 7 publications

(5 citation statements)

References 29 publications

(34 reference statements)

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“…AD-MET (absorption, distribution, metabolism, excretion and toxicity) analysis of artemisinin showed that it was non-cytotoxic, had good aqueous solubility and a good permeability through the blood-brain barrier with a promising therapeutic potential. Furthermore, molecular docking studies revealed that artemisinin bound to all four proteins and in some cases displayed better binding modes than hydroxychloroquine [85][86][87][88][89]. Thus, ARTs could serve as best leads for further drug development process for SARS-CoV-2 infection.…”

Section: Anti-viralmentioning

confidence: 99%

“…Owing to their potent anti-inflammatory, immunoregulatory and antiviral properties, ARTs are being pursued for their activity against SARS-CoV-2 infection. Researchers used in silico approaches to investigate if artemisinin or its derivatives could physically bind any of the COVID-19 target proteins including SARS-CoV-2 spike glycoprotein, spike ectodomain structural protein, the main protease of the virus (M Pro ) or spike receptor-binding domain, thereby preventing SARS-CoV-2 from binding to the host receptor ACE2 [83][84][85][86][87][88][89]. AD-MET (absorption, distribution, metabolism, excretion and toxicity) analysis of artemisinin showed that it was non-cytotoxic, had good aqueous solubility and a good permeability through the blood-brain barrier with a promising therapeutic potential.…”

Section: Anti-viralmentioning

confidence: 99%

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Antiviral and Immunomodulation Effects of Artemisia

Kshirsagar¹,

Rao²

2021

Medicina

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Background and Objectives: Artemisia is one of the most widely distributed genera of the family Astraceae with more than 500 diverse species growing mainly in the temperate zones of Europe, Asia and North America. The plant is used in Chinese and Ayurvedic systems of medicine for its antiviral, antifungal, antimicrobial, insecticidal, hepatoprotective and neuroprotective properties. Research based studies point to Artemisia’s role in addressing an entire gamut of physiological imbalances through a unique combination of pharmacological actions. Terpenoids, flavonoids, coumarins, caffeoylquinic acids, sterols and acetylenes are some of the major phytochemicals of the genus. Notable among the phytochemicals is artemisinin and its derivatives (ARTs) that represent a new class of recommended drugs due to the emergence of bacteria and parasites that are resistant to quinoline drugs. This manuscript aims to systematically review recent studies that have investigated artemisinin and its derivatives not only for their potent antiviral actions but also their utility against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials andMethods: PubMed Central, Scopus and Google scholar databases of published articles were collected and abstracts were reviewed for relevance to the subject matter. Conclusions: The unprecedented impact that artemisinin had on public health and drug discovery research led the Nobel Committee to award the Nobel Prize in Physiology or Medicine in 2015 to the discoverers of artemisinin. Thus, it is clear that Artemisia’s importance in indigenous medicinal systems and drug discovery systems holds great potential for further investigation into its biological activities, especially its role in viral infection and inflammation.

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Section: Anti-viralmentioning

confidence: 99%

Section: Anti-viralmentioning

confidence: 99%

Antiviral and Immunomodulation Effects of Artemisia

Kshirsagar¹,

Rao²

2021

Medicina

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“…Several studies have demonstrated the effects of various natural bioactive compounds/secondary metabolites in the therapeutic world. (Pandey et al, 2011;Rai et al, 2012;Arora and Pandey-Rai, 2012;Pandey and Pandey-Rai, 2014;Arora et al, 2017;Pandey-Rai, et al, 2018;Goswami et al, 2019, Rai et al, 2020aRai et al, 2020b;Apoorva et al, 2021Rai et al, 2022;. Recently, the beneficial effects of papaya in curing dengue fever along with homeostatic properties have been also reported.…”

Section: Research Articlementioning

confidence: 99%

Enhancing Production Through Input Use Efficiency of Virus-Resistant Pune Selection-3 Papaya Variety

Kumar

Singh

Kumar

et al. 2022

Int J Appl Sci Biotechnol

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An experiment was carried out using virus-resistant papaya variety Pune Selection-3 to study the effect of different cultivation methods for enhanced production and input use efficiency at Horticultural Research Farm, RAU, Pusa during the year 2016-2019. The outcomes of raised bed cultivation (a), drip irrigation (b), fertigation (c), polyethylene mulching (d) along with micronutrient spray (e) were analyzed using different combinations of these parameters as treatments for growth, yield-related parameters, and fruit quality. Nutrient use efficiency was also assessed by examining various interactive components such as soil nutrient content, nutrient acquisition with nutrient content in the leaves, the efficiency of nutrient utilization informs of the biomass produced, fruit yield, and fruit nutritional quality. The plant height was maximum in T1 (155 cm) which was significantly higher than the plant of control treatment. The flowering time was found to be reduced in all treatments. However, total soluble sugar was higher in T3. Overall, when the B:C ratio was compared, the treatment (T1) showed a higher value along with a 2.38-fold fruit yield/plant and 0.89-fold increase in fruit yield per hectare. The nutritional quality of fruits enhanced in T1 treated plants having a 1.78-fold increment in flavonoid content, and 1.2-fold more lycopene. The phenolic content was also 1.8-fold higher than the control (T5). The result obtained in the present study demonstrates that with the implementation of a suitable fertigation system in papaya cultivation we can obtain papaya growth, fruit yield per plant, and fruit quality by targeting enhancement in cost: benefit ratio. Int. J. Appl. Sci. Biotechnol. Vol 10(2): 84-92.

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“…Artemisinin and its derivatives present in the leaf of A. Annua are known as potential antimalarial due to their high efficiency and mainly for the downregulation of T&B cell activation, thus inhibiting the production of antibodies [53]. Another study states that corticosteroids reduce mortality in patients with severe COVID-19 and remdesivir can reduce the need for mechanical ventilation but has no effect on mortality.…”

Section: Other Potential Therapies Against Covid-19mentioning

confidence: 99%

Research Into Potential Therapies Against COVID-19, With Focus On Ivermectin

Khanghah¹

2022

Preprint

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Purpose: Ivermectin is a broad-spectrum antiparasitic and an effective drug to treat COVID-19. In this article, we looked at the effects of ivermectin on coronavirus and its patients in three ways. We have discussed and organized other previously discovered potential therapies and reviewed them in Table 2 and in the last section.Methods: We searched for articles on MedRxiv, PubMed, Google Scholar, MEDLINE, EMBASE uses the appropriate search terms. ClinicalTrials.gov was searched for available clinical trials evaluating the effectiveness of ivermectin. We also use EU clinical trial registry data and ANZ registry data for clinical trials. Also, we performed our methods in 4 stages: Identifying studies, Selection of Studies, Collating Studies, Reporting results.Results: Results are variable. Some studies have shown the effectiveness of ivermectin, others have not. Furthermore, some studies show that a combination of ivermectin with other drugs is useful.Conclusion: Overall, we believe the reason ivermectin is useful is that it goes back to its origin, which is soil. Our theory and hypothesis is that if the coronavirus, created by man or by nature, can generally be treated with nature, that is, the soil. The interesting thing is that today we know that ivermectin is effective in the fight against the coronavirus. In fact, other drugs like teicoplanin, cyclosporine and rapamycin that are effective against the coronavirus have come from the soil. We hope that this article has been able to take a step in finding a corona drug, InshaAllah.

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Repurposing Artemisia annua L. Flavonoids, Artemisinin and Its Derivatives as Potential Drugs Against Novel Coronavirus (SARS –nCoV) as Revealed by In-Silico Studies

Cited by 7 publications

References 29 publications

Antiviral and Immunomodulation Effects of Artemisia

Antiviral and Immunomodulation Effects of Artemisia

Enhancing Production Through Input Use Efficiency of Virus-Resistant Pune Selection-3 Papaya Variety

Research Into Potential Therapies Against COVID-19, With Focus On Ivermectin

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