Etiological correlation of human papillomavirus infection in the development of female bladder tumor

Abstract

The critical factors and etiological role of human papillomavirus (HPV) infection in the development of female bladder tumor were examined. Eighty-four female patients with primary bladder tumor were studied. After DNA extraction from each paraffin-embedded tissue, HPV-DNA and genotype were checked. In cases of all HPV-positive cases and some HPV-negative cases, in situ hybridization (ISH) for high-risk HPV-DNA, and immunohistochemical analysis for p16-INK4a were performed. HPV-DNA was detected in 5 (6.0%) of 84 eligible patients, and HPV16 was detected in 3 patients, and HPV6 and HPV52 was detected in one case, respectively. HPV-DNA was detected frequently in younger patients and in patients with a history of cervical cancer. In four high-risk HPV-positive cases, high-risk HPV-DNA was present in tumor tissues, and p16-INK4a was expressed moderately or strongly. Two cases had a past history of cervical cancer. In these 2 cases, the same HPV type (HPV16) was detected from bladder tumor and cervical cancer. High-risk HPV-DNA ISH signals and p16-INK4A expression were also detected widely in these cervical cancer tissues. HPV infection is likely to play an important role in the development of female bladder tumor at younger cases with a past history of cervical cancer.

Human papillomavirus‐related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

“…In the present case, as in the others reported in the literature, we presume that frequent catheterizations contributed to recurrent infections and inflammation of the bladder leading to loss of urothelial integrity and development of squamous metaplasia, creating an environment analogous to the transformation zone of the cervix, and exposing the basement membrane to HPV. The role of HPV in bladder carcinogenesis is still unclear, although some studies have shown a correlation, especially in women with a past history of cervical cancer . Recently, Steinestel et al .…”

“…The role of HPV in bladder carcinogenesis is still unclear, although some studies have shown a correlation, especially in women with a past history of cervical cancer. [6][7][8] Recently, Steinestel et al have reported that the frequently observed overexpression of p16 in urothelial carcinoma in situ is not associated with HPV infection, but is a consequence of enhanced rat sarcoma/mitogen-activated protein kinase signaling that promotes epithelial-mesenchymal transition. 9 According to this, they have observed a loss of membranous expression of e-cadherin and beta-catenin, which are proteins involved in the epithelial-mesenchymal transition, and a nuclear positivity for these antibodies in the neoplastic urothelial cells.…”

Editorial Comment to Human papillomavirus‐related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

“…Indeed, HPV-positive bladder carcinoma is reportedly associated with cervical neoplasm risk. 6 In a study carried out to determine the critical factors and the etiological role of HPV infection in the development of female bladder tumors, it was found that HPV-DNA was detected in five of 84 patients (6.0%), and two HPV-positive cases had a past history of cervical cancer. 6 Furthermore, that study showed that the same HPV type 16 was detected in the bs_bs_banner © 2014 The Japanese Urological Association A GINORI ET AL.…”

“…Interestingly, there was a past history of cervical intraneoplasia in the present case. Indeed, HPV‐positive bladder carcinoma is reportedly associated with cervical neoplasm risk . In a study carried out to determine the critical factors and the etiological role of HPV infection in the development of female bladder tumors, it was found that HPV‐DNA was detected in five of 84 patients (6.0%), and two HPV‐positive cases had a past history of cervical cancer .…”

Comparative analysis of 13 HPV genotypes diagnosed in urine sediment cells vs. desquamated cervical epithelial cells

“…A thorough search through available medical literature databases identified only one report, dealing with the presence of HPV in DNA samples, obtained from urinary and cervical cancers (12). However, no similar publications were found on DNA samples, collected either from urinary sediments or from desquamated epithelial cells of the uterine cervix in cases of frequent, recurrent cystitis.…”