Human papillomavirus‐related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

Ginori, Alessandro; Barone, Aurora; Santopietro, Rosa; Barbanti, Gabriele; Cecconi, F; Tripodi, Sergio

doi:10.1111/iju.12633

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…Basaloid-squamous cell carcinomas are aggressive neoplasms mainly located in the head and neck [46] and anal [47] regions. The tumor is extraordinarily uncommon in the urinary tract, with only a handful of single cases published to date [48][49][50][51]. Everywhere, most basaloid squamous cell carcinomas are associated with HPV infection [51].…”

Section: Basaloid-squamous Cellsmentioning

confidence: 99%

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Unusual Faces of Bladder Cancer

Manini

López

2020

Cancers

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The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architecture and cytology. Thus, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.

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Section: Basaloid-squamous Cellsmentioning

confidence: 99%

“…The tumor is extraordinarily uncommon in the urinary tract, with only a handful of single cases published to date [48][49][50][51]. Everywhere, most basaloid squamous cell carcinomas are associated with HPV infection [51].…”

Section: Basaloid-squamous Cellsmentioning

confidence: 99%

Unusual Faces of Bladder Cancer

Manini

López

2020

Cancers

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“…In cases associated with schistosomal infection, parasite eggs may be identified (Figure ). A basaloid SCC phenotype has been reported and is often associated with HPV . Stromal reactions may include a giant cell reaction to keratin, prominent desmoplasia and inflammation, including the presence of neutrophils …”

Section: Bladder Cancers With Squamous Morphologymentioning

confidence: 99%

“…A basaloid SCC phenotype has been reported and is often associated with HPV. 16,17 Stromal reactions may include a giant cell reaction to keratin, prominent desmoplasia and inflammation, including the presence of neutrophils. 5 Surface changes that occur in the presence of SCC are varied and include squamous and non-squamous alterations.…”

Section: Bladder Cancers With Squamous Morphology S Q U a M O U S C Ementioning

confidence: 99%

Non‐urothelial carcinomas of the bladder

2018

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Non‐urothelial carcinomas involving the bladder are uncommon and often diagnostically challenging. These carcinomas may show squamous, adenocarcinomatous or neuroendocrine features, with immunohistochemical stains aiding the diagnosis in only a subset of cases. The clinical history in non‐urothelial bladder carcinomas is important, given that the differential diagnosis often includes secondary involvement of the bladder by direct extension or metastasis from carcinomas at other sites. This paper will review non‐urothelial carcinomas in each of these three morphological categories, emphasising recent changes in diagnostic grouping and challenges in the histopathological diagnosis. Review of bladder cancers with squamous morphology will include discussion of conventional squamous cell carcinoma and verrucous carcinoma and their distinction from urothelial carcinoma with extensive squamous differentiation. Bladder carcinomas with adenocarcinomatous change will include primary bladder adenocarcinoma, urachal adenocarcinoma and tumours of Müllerian type. Finally, neuroendocrine neoplasms of the bladder, including well‐differentiated neuroendocrine tumour and neuroendocrine carcinomas, will be discussed. Associated surface findings, risk factors and prognostic features will be described.

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“…The article by Ginori et al describes a case of BSCC with a concomitant HPV-16 infection, and discusses the etiological role of HPV infection in the development of BSCC by means of immunohistochemical analysis including staining for p16. 4 Cellular protein p16 is a cyclin-dependent kinase inhibitor that stops the cell cycle, and its expression increases according to cell cycle progression. Oncogenic HPV-E7 protein can bind and inactivate Rb protein, and promote cell division by releasing transcription factor E2F.…”

Section: Editorial Comment To Human Papillomavirus-related Basaloid Smentioning

confidence: 99%

Editorial Comment to Human papillomavirus‐related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

Shigehara

Namiki

2014

Int J of Urology

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that the overexpression of p16 in these bladder neoplasms is a marker of HPV infection. However, further studies are required to better understand the epithelial-mesenchymal transition of BSCC of the bladder and the role of HPV in these neoplasms. Conflict of interestNone declared. Sarcomatoid carcinoma with a predominant basaloid squamous carcinoma component: the first report of an unusual biphasic tumor of the ureter. References

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Human papillomavirus‐related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

Cited by 5 publications

References 10 publications

Unusual Faces of Bladder Cancer

Unusual Faces of Bladder Cancer

Non‐urothelial carcinomas of the bladder

Editorial Comment to Human papillomavirus‐related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

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