Ethyl 1-(4-chlorobenzyl)-3-phenyl-1H-pyrazole-5-carboxylate

Abstract

Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.003 Å; R factor = 0.039; wR factor = 0.107; data-to-parameter ratio = 13.8.In the title compound, C 19 H 17 ClN 2 O 2 , the pyrazole ring makes dihedral angles of 6.97 (5) and 79.25 (1) , respectively, with the phenyl and chlorophenyl rings, respectively. In the crystal, C-HÁ Á ÁO hydrogen bonds are observed. Related literature

Ethyl 1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate

“…1) the dihedral angle between the benzene ring (C2-C7) and the pyrazole ring (N1/N2/C8-C10) is 5.63 (2) °. All bond lengths and angles are normal and in a good agreement with those reported previously for related compounds (Dong et al, 2007;Hao et al, 2012) (Table 1).…”

“…For the biological activity of pyrazole compounds, see: Nagwa et al (2012); Fahmy et al (2012); Wang et al (2011). For related structures, see: Dong et al (2007); Hao et al (2012). (2) 130Symmetry codes: (i) Àx þ 1; Ày; Àz; (ii) Àx þ 1; y; Àz þ 1 2 .…”

3-(4-Bromophenyl)-1-(4-chlorobenzyl)-1H-pyrazole-5-carbaldehyde

“…The pyrazole ring makes dihedral angles of 3.29 (9) and 74.91 (4)°, respectively, with the bromophenyl and chlorophenyl rings. This conformation is close to that found in a related pyrazole derivative (Hao et al, 2012).…”

4-Acetyl-1H-pyrrole-2-carbaldehyde

“…For the synthetic procedure, see: Ge et al (2009). For related structures, see: Ge et al (2011); Hao et al (2012).…”