Ethnopharmacological properties of Artemisia asiatica: A comprehensive review

Ahuja, Akash; Yi, Young-Su; Kim, Mi‐Yeon; Cho, Jae Youl

doi:10.1016/j.jep.2018.03.032

Cited by 27 publications

(19 citation statements)

References 58 publications

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“…The various non-volatile, volatile, flavonoids, phenolic acids, coumarin derivatives, monoterpene, and sesquiterpene constituents of Artemisia species were informed (Wallaart et al 1999;Aberham et al 2010;Khan et al 2016;Ahuja et al 2018;Nigam et al 2019) given in the Fig. 1…”

Section: Chemical Constituents Of Genus Artemisia Speciesmentioning

confidence: 99%

“…Artemisia vulgaris, L. was employed as an essential remedy for women's sickness in folk medicament. The genus has been certified for its remedial, curative, and therapeutic medicinal virtues, employed to synthesize essential oil used in medicine, food commodities, and cosmetics (Teixeira 2004;Verma et al 2006;Ahuja et al 2011Ahuja et al , 2018Pal and Ghosh 2018). Artemisia nilagirica regionally designated as "Indian wormwood" pertains to the Asteraceae family (Suresh et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Phytochemistry and pharmacological activity of the genus artemisia

et al. 2021

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Section: Chemical Constituents Of Genus Artemisia Speciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemistry and pharmacological activity of the genus artemisia

et al. 2021

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“…Despite of the huge literature (including several reviews) published on the phytochemistry and pharmacology of Artemisia 's derived natural products, there is no review present on the chemistry and pharmacology of Artemisia 's alkaloids and allied nitrogen compounds (Abad, Bedoya, Apaza, & Bermejo, ; Aglarova, Zilfikarov, & Severtseva, ; Ahuja, Yi, Kim, & Cho, ; Bora & Sharma, ; Bora & Sharma, ; Brown, ; Cosoveanu & Cabrera, ; Duke, ; Goud & Swamy, ; Obolskiy, Pischel, Feistel, Glotov, & Heinrich, ; Pellicer, Garnatje, & Vallès, ; Phan, Tran, Phan, Otsuka, & Matsunami, ; Tan, Zheng, & Tang, ; Tang, Hu, Yang, & Tan, ; Turi et al, ; Vallès et al, ; Vasconcelos, Silva, & Cavaleiro, ; Wright, ; Wu, Shi, & Jia, ). This review highlights the significance of bioactive Artemisia alkaloids, exploring their chemistry and pharmacological uses along with their biosynthetic proposal (few only).…”

Section: Introductionmentioning

confidence: 99%

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

Rashid

Alamzeb²,

Ali³

et al. 2019

Phytotherapy Research

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Several reviews have been published on Artemisia's derived natural products, but it is the first attempt to review the chemistry and pharmacology of more than 80 alkaloids and allied nitrogen compounds obtained from various Artemisia species (covering the literature up to June 2018). The pharmacological potential and unique skeleton types of certain Artemisia's alkaloids provoke the importance of analyzing Artemisia species for bioactive alkaloids and allied nitrogen compounds. Among the various types of bioactive Artemisia's alkaloids, the main classes were the derivatives of rupestine (pyridine–sesquiterpene), lycoctonine (diterpene), pyrrolizidine, purines, polyamine, peptides, indole, piperidine, pyrrolidine, alkamides, and flavoalkaloids. The rupestine derivatives are Artemisia's characteristic alkaloids, whereas the rest are common alkaloids found in the family Asteraceae and chemotaxonomically links the genus Artemisia with the tribes Anthemideae. The most important biological activities of Artemisia's alkaloids are including hepatoprotective, local anesthetic, β‐galactosidase, and antiparasitic activities; treatment of angina pectoris, opening blocked arteries, as a sleep‐inducing agents and inhibition of HIV viral protease, CYP450, melanin biosynthesis, human carbonic anhydrase, [3H]‐AEA metabolism, kinases, and DNA polymerase β1. Some of the important nitrogen metabolites of Artemisia include pellitorine, zeatin, tryptophan, rupestine, and aconitine analogs, which need to be optimized and commercialized further.

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“…Luo et al [22] summarized evidences on the efficacy and safety of clinical application of tripterygium glycosides and total glucosides of paeony, suggesting that they might be potential beneficial complementary and alternative medicines for RA patients. Artemisia asiatica has a long history of ethnopharmacological use in Asian countries such as China, Korea, and Japan, and a novel antioxidative and anti-inflammatory formulation prepared from the ethanol extracts of Artemisia asiatica named DA-9601 is now on sale in South Korea [23,24]. A recent study [25] has shown that DA-9601 injection reduced arthritis scores in collagen-induced arthritis mice; moreover, eupatilin, the main active component of DA-9601, could markedly downregulate the expression of inflammatory cytokines and suppress the differentiation of osteoclasts, indicating that DA-9601 and eupatilin are candidate anti-inflammatory agents.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Integrated Traditional Chinese Medicine and Western Medicine on the Treatment of Rheumatoid Arthritis: A Meta‐Analysis

Xing

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. Integrated therapy of traditional Chinese medicine (TCM) and Western medicine (WM) has gradually been applied to the treatment of rheumatoid arthritis (RA). Recently published studies have provided a wealth of data and information about the effectiveness of combination treatments, but high-quality evidence-based meta-analysis on this issue is not available yet. This study was conducted to compare and evaluate the efficacy and safety of the integrated therapy for RA. Methods. PubMed, EMBASE, and the Cochrane Library were searched up to January 2020. Randomized controlled trials (RCTs) that compared the efficacy and safety of integrative TCM-WM with WM alone for RA were included. The outcome measures contained therapeutic effects (TEs), tender joint count (TJC), swollen joint count (SJC), duration of morning stiffness (DMS), grip strength (GS), disease activity score in 28 joints (DAS28), rheumatoid factor (RF), anti-cyclic peptide containing citrulline (anti-CCP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and adverse events (AEs) to assess the efficacy and safety of different treatments. Results. A total of 20 RCTs with 2269 patients met the inclusion criteria. TCM used in these studies included Chinese herbal decoctions and tablets or capsules made from herbs and their extracts, while WM included disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), and glucocorticoids (GC). Compared with patients receiving WM treatment alone, patients with integrative TCM-WM treatment showed better TEs (OR = 3.03, 95% CI [2.36, 3.88]). The integrative treatment group showed reductions in TJC (MD = −1.17, 95% CI [−2.12, −0.21]), SJC (MD = −0.87, 95% CI [−1.85, 0.10]), DMS (SMD = −0.69, 95% CI [−0.98, −0.41]), DAS28 (MD = −0.43, 95% CI [−0.57, −0.29]), RF (SMD = −0.59, 95% CI [−0.91, −0.27]), anti-CCP (SMD = −0.21, 95% CI [−0.36, −0.06]), ESR (MD = −8.36, 95% CI [−12.60, −4.12]), and CRP (MD = −6.73, 95% CI [−9.38, −4.08]), and increment in GS (SMD = 0.12, 95% CI [−0.63, 0.87]). AEs, especially gastrointestinal disorders, abnormal liver function, leukopenia, skin allergies and rashes, headaches and dizziness, and alopecia, significantly decreased (OR = 0.37, 95% CI [0.29, 0.47]) in the integrative treatment group. Conclusions. The findings of this meta-analysis indicate that integrative TCM-WM could obtain effective and safe results in the treatment of RA. Using TCM as an adjunctive therapy in RA has great prospects for further development.

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Ethnopharmacological properties of Artemisia asiatica: A comprehensive review

Cited by 27 publications

References 58 publications

Phytochemistry and pharmacological activity of the genus artemisia

Phytochemistry and pharmacological activity of the genus artemisia

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

Efficacy and Safety of Integrated Traditional Chinese Medicine and Western Medicine on the Treatment of Rheumatoid Arthritis: A Meta‐Analysis

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